Maternal 25-Hydroxyvitamin D Deficiency Promoted Metabolic Syndrome and Downregulated Nrf2/CBR1 Pathway in Offspring

Zheng, Jianqiong; Liu, Xiaohui; Zheng, Bingbing; Zheng, Zhenzhen; Zhang, Hongping; Zheng, Jiayong; Sun, Congcong; Chen, Haiying; Yang, Jie; Zuo, Wang; Lin, Meimei; Chen, Jingjing; Zhou, Quanhong; Zheng, Zhi; Xu, Xiaoming; Hao, Ying

doi:10.3389/fphar.2020.00097

Cited by 14 publications

(8 citation statements)

References 40 publications

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“…Numerous studies have reported that VD insufficiency or deficiency increases the risk of MetS [ 127 ] and that VD supplementation improves outcomes in patients, including improving insulin sensitivity and β-cell function, decreasing fasting glucose level, insulin, and hemoglobin A1c (HbA1c), increasing HDL level and reducing LDL and TG, and reducing the incidence of type 2 diabetes [ 128 ]. As in pregnant individuals and their babies, a rat model suggested that maternal VD deficiency promotes MetS in both mothers and offspring, and VD treatment may attenuate the offspring’s MetS [ 129 ].…”

Section: The Relationship Of Vd Deficiency During Pregnancy and Obesi...mentioning

confidence: 99%

The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review

Zeng

Zhang

et al. 2023

Nutrients

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Currently, vitamin D (VD) deficiency during pregnancy is widespread globally, causing unfavorable pregnancy outcomes for both mothers and infants for a longer time than expected, based on the Developmental Origins of Health and Disease (DOHaD) theory. As VD plays a key role in maintaining normal glucose and lipid metabolism, maternal VD deficiency may lead to obesity and other obesity-related diseases among offspring later in life. This review mainly focuses on the effect of maternal VD deficiency on offspring lipid metabolism, reviewing previous clinical and animal studies to determine the effects of maternal VD deficit on offspring obesity and potential mechanisms involved in the progression of offspring obesity. Emerging clinical evidence shows that a low VD level may lead to abnormal growth (either growth restriction or largeness for gestational age) and lipid and glucose metabolism disorders in offspring. Here, we also outline the link between maternal VD deficiency and life-long offspring effects, including the disorder of adipogenesis, the secretion of adipocytokines (including leptin, resistin, and adiponectin), activated systemic inflammation, increased oxidative reactions in adipose tissue, insulin resistance, and abnormal intestinal gut microbiota. Thus, there is an urgent need to take active steps to address maternal VD deficiency to relieve the global burden of obesity.

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Section: The Relationship Of Vd Deficiency During Pregnancy and Obesi...mentioning

confidence: 99%

The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review

Zeng

Zhang

et al. 2023

Nutrients

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“…To selectively inhibit lung cancer, Yang et al further developed their tandem self-assembly approach. 481 As shown in Figure 78C, they designed a peptide derivative, NBD-GFF p YG-N=N-ERGD (233), which was the substrate of both ALP and reductase. According to the authors, ectoenzyme, ALP, converts 233 to NBD-GFFYG-N=N-ERGD (234).…”

Section: Peri/intracellular Ensmentioning

confidence: 99%

Enzymatic Noncovalent Synthesis

et al. 2020

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Enzymatic reactions and noncovalent (i.e., supramolecular) interactions are two fundamental nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process where enzymatic reactions control intermolecular noncovalent interactions for spatial organization of higher-order molecular assemblies that exhibit emergent properties and functions. Like enzymatic covalent synthesis (ECS), in which an enzyme catalyzes the formation of covalent bonds to generate individual molecules, ENS is a unifying theme for understanding the functions, morphologies, and locations of molecular ensembles in cellular environments. This review intends to provide a summary of the works of ENS within the last decade and emphasize ENS for functions. After comparing ECS and ENS, we describe a few representative examples where nature uses ENS, as a rule of life, to create the ensembles of biomacromolecules for emergent properties/functions in a myriad of cellular processes. Then, we focus on ENS of man-made (synthetic) molecules in cell-free conditions, classified by the types of enzymes. After that, we introduce the exploration of ENS of man-made molecules in the context of cells by discussing intercellular, peri/intracellular, and subcellular ENS for cell morphogenesis, molecular imaging, cancer therapy, and other applications. Finally, we provide a perspective on the promises of ENS for developing molecular assemblies/processes for functions. This review aims to be an updated introduction for researchers who are interested in exploring noncovalent synthesis for developing molecular science and technologies to address societal needs.

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“…They observed that decreased expression of Nrf2/CBR1 pathway is one of the causes of oxidative stress leading to metabolic syndrome in both mothers and their offspring. 55 Multiple reports indicating Nrf2's role in GDM have led to investigations examining Nrf2 as a potential therapeutic target to improve maternal and neonatal outcomes in patients with GDM and metabolic syndrome. Metformin restored the GDM-induced impairment of angiogenesis in the placenta.…”

Section: 25mentioning

confidence: 99%

The role of nuclear factor erythroid 2–related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review

Tantengco

Silva

Shahin

et al. 2021

American J Rep Immunol

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Objective: A homeostatic balance between reactive oxygen species production and the antioxidant redox system is an important component of normal pregnancy. Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) preserves cellular homeostasis by enhancing the cell's innate antioxidant status to reduce oxidative stress and inflammatory damage to the cell during pregnancy. Active Nrf2, in the nucleus of the cell, transactivates various antioxidant genes. The objective of this systematic review was to synthesize evidence on the role of Nrf2 in various adverse pregnancy outcomes (APOs). Methods:We conducted a systematic review of the role of Nrf2 in pregnancy. Articles written in English, Portuguese, and Spanish were obtained from three different databases from inception until January 2021. The titles, abstracts and full text were reviewed independently by six reviewers. The quality of the included studies was assessed using a quality assessment tool developed to assess basic science and clinical studies. Nrf2 expression (gene and protein), functional contributions, and association with APOs were assessed.Results: A total of 747 citations were identified; 80 were retained for full review.Most studies on Nrf2 have been carried out using placental tissues and placentaderived cells. Limited studies have been conducted using fetal membranes, uterus, and cervix. Nuclear translocation of Nrf2 results in transactivation of antioxidant enzymes, including glutathione peroxidase, hemeoxygenase-1, and superoxide dismutase in gestational cells during pregnancy. This antioxidant response maintains cellular homeostasis during pregnancy. This promotes trophoblast cell survival and prevents cell death and abnormal angiogenesis in the placenta. Excessive and insufficient Nrf2 response may promote oxidative and reductive stress, respectively. This Nrf2 dysregulation has been associated with APOs including gestational diabetes mellitus, intrauterine growth restriction, reproductive toxicity, preeclampsia, and preterm birth. Conclusion:Several studies have localized and reported an association between Nrf2's differential expression in reproductive tissues and the pathogenesis of APOs. However, a comprehensive functional understanding of Nrf2 in reproductive tissues is still

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Maternal 25-Hydroxyvitamin D Deficiency Promoted Metabolic Syndrome and Downregulated Nrf2/CBR1 Pathway in Offspring

Cited by 14 publications

References 40 publications

The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review

The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review

Enzymatic Noncovalent Synthesis

The role of nuclear factor erythroid 2–related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review

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