Maternal age, ethnicity and gestational diabetes mellitus

Carolan, Mary; Davey, Mary‐Ann; Biró, Mary Anne; Kealy, Michelle

doi:10.1016/j.midw.2011.08.014

Cited by 81 publications

(72 citation statements)

References 40 publications

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“…Our approach was similar to that of several studies designed with the aim to identify the best diagnostic approach for GDM (19,20,21,22,23). In the European countries, the nonconformity of screening and diagnostic procedures for GDM is responsible for the different reported prevalence rates of GDM (6).…”

Section: Discussionmentioning

confidence: 97%

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Improvement of selective screening strategy for gestational diabetes through a more accurate definition of high-risk groups

Pintaudi

Vieste

Corrado

et al. 2014

European Journal of Endocrinology

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Objective: This study aimed to assess the predictive value of risk factors (RFs) for gestational diabetes mellitus (GDM) established by selective screening (SS) and to identify subgroups of women at a higher risk of developing GDM. Design: A retrospective, single-center study design was employed. Methods: Data of 1015 women screened for GDM at 24-28 weeks of gestation and diagnosed according to the International Association of Diabetes and Pregnancy Study Groups criteria were evaluated. Information on RFs established by SS was also collected and their association with GDM was determined. To identify distinct and homogeneous subgroups of patients at a higher risk, the RECursive Partitioning and AMalgamation (RECPAM) method was used. Results: Overall, 113 (11.1%) women were diagnosed as having GDM. The application of the SS criteria would result in the execution of an oral glucose tolerance test (OGTT) in 58.3% of women and 26 (23.0%) cases of GDM would not be detected due to the absence of any RF. The RECPAM analysis identified high-risk subgroups characterized by fasting plasma glucose values O5.1 mmol/l (odds ratio (OR)Z26.5; 95% CI 14.3-49.0) and pre-pregnancy BMI (ORZ7.0; 95% CI 3.9-12.8 for overweight women). In a final logistic model including RECPAM classes, previous macrosomia (ORZ3.6; 95% CI 1.1-11.6), and family history of diabetes (ORZ1.8; 95% CI 1.1-2.8), but not maternal age, were also found to be associated with an increased risk of developing GDM. A screening approach based on the RECPAM model would reduce by over 50% (23.0 vs 10.6%) the number of undiagnosed GDM cases when compared with the current SS approach, at the expense of 50 additional OGTTs required. Conclusions: A screening approach based on our RECPAM model results in a significant reduction in the number of undetected GDM cases compared with the current SS procedure.

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Section: Discussionmentioning

confidence: 97%

“…NICE (5) has decided not to consider maternal age as a RF. The predictive value of maternal age in the development of GDM has been evaluated in several studies and the risk associated has been shown to be higher with increasing age (20,21,28,29). However, other authors have not reported a much higher risk for older women (22,30).…”

Section: Discussionmentioning

confidence: 99%

Improvement of selective screening strategy for gestational diabetes through a more accurate definition of high-risk groups

Pintaudi

Vieste

Corrado

et al. 2014

European Journal of Endocrinology

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“…Its prevalence in the US and European countries is 3% -7% and 2% -6%, respectively (3)(4)(5). A higher incidence rate was reported in Asian, Indian, and African women (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Indicators of Obesity and Serum Levels of Triglycerides in the First Trimester of Pregnancy as the Predictors of Gestational Diabetes Mellitus among Urmia Women

et al. 2018

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Background: Obesity is a major risk factor of gestational diabetes mellitus (GDM), therefore, we aimed to determine which indicators of obesity can be used as predictors of GDM and also to study the association of maternal serum levels of triglycerides (TG) in early pregnancy to expression of GDM. Methods: A total of 436 primigravida women, who attended public health centers in 6 -10 weeks of gestation, were prospectively followed until 24 -28 weeks of gestation to control the expression of GDM. The indicators of abdominal obesity and the serum concentration of TG were measured at 6-10 weeks of gestation. All participants underwent a 75 g oral glucose tolerance test (OGTT) as a routine test at 24 -28 weeks. Results: The incidence of GDM among our participants was 9.6%. The serum concentration of TG in 16.5% of them was more than 199 mg\dL. The majority of participants (62.8%) had a body mass index (BMI) more than its normal range. Waist circumference (WC) in the majority (84.4%) was 80 -95.9 cm. The mean (SD) waist to height ratio (WHtR) and waist to hip ratio (WHR) were 0.58 (0.05) and 0.84 (0.06), respectively. WC, WHtR, WHR, BMI, and the serum levels of TG in early pregnancy are associated with the expression of GDM. Conclusions: Abdominal obesity and serum levels of TG can be used as early predictors of GDM. Strategies consisted of monitoring of TG levels in women planning for pregnancy as well as training obese and overweight women to modify their lifestyle in the means of decreasing the body fat mass can help to partially prevent GDM.

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“…Higher prevalence of GDM has been reported in African, Asian, Indian and Hispanic women [15] [16] [17]. Other documented risk factors are advanced maternal age, high parity, obesity, polycystic ovarian syndrome (PCOS), multiple pregnancy, family history of diabetes, history of congenital malformation, still birth, macrosomia and previous GDM [18].…”

Section: Introductionmentioning

confidence: 99%

Prediction of Gestational Diabetes Mellitus in Early Pregnancy: Is Abdominal Skin Fold Thickness 20 mm or More an Independent Risk Predictor?

Oriji¹,

Ojule²,

Fumudoh³

2017

JBM

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Background: Gestational Diabetes Mellitus (GDM) is associated with several maternal and perinatal complications. Early detection and treatment can improve pregnancy outcomes. Objectives: To determine the prevalence, risk factors and predictors of GDM in early pregnancy at the University of Port Harcourt Teaching Hospital, (UPTH), Port Harcourt Nigeria. Methods: A cohort of 235 mothers who registered for antenatal care between 15 -18 weeks of gestation at UPTH was prospectively studied. Their socio-demographic data, examination findings, anthropometric measurements, fasting blood sugar at booking and OGTT results at 28 weeks gestation were collated and entered into PC with SPSS for windows version 21.0 which was also used for the analysis. Variables were expressed as absolute numbers, percentages or means with standard deviations and significant differences determined using chi square test or the student "t" test as appropriate. The level of significance was set at P < 0.05. Results: Of the 235 participants, 35 (14.9%) developed GDM.Women who had GDM were significantly older (P = 0.001), had higher weight (t = 2.95, P = 0.01), BMI (t = 2.29, P = 0.02), abdominal skin fold thickness (t = 4.15, P = 0.001), blood pressure (t = 3.38, P = 0.001) compared to women who did not. Previous history of GDM was significantly different between two groups as χ 2 = 93.56 and P = 0.001. Abdominal skin fold thickness and prior GDM history were found to be independent predictors of GDM on application of multiple logistic regression analysis. Conclusion: The prevalence of GDM in Port Harcourt is 14.9% and major risk factors are obesity, previous GDM history, advanced age and hypertension. Abdominal skin fold thickness ≥ 20 mm is an independent predictor. The risk of developing GDM can be

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Maternal age, ethnicity and gestational diabetes mellitus

Cited by 81 publications

References 40 publications

Improvement of selective screening strategy for gestational diabetes through a more accurate definition of high-risk groups

Improvement of selective screening strategy for gestational diabetes through a more accurate definition of high-risk groups

Indicators of Obesity and Serum Levels of Triglycerides in the First Trimester of Pregnancy as the Predictors of Gestational Diabetes Mellitus among Urmia Women

Prediction of Gestational Diabetes Mellitus in Early Pregnancy: Is Abdominal Skin Fold Thickness 20 mm or More an Independent Risk Predictor?

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