Maternal allergic disease does not affect the phenotype of T and B cells or the immune response to allergens in neonates

Rindsjö, Erika; Joerink, Maaike; Johansson, Catharina; Bremme, Katarina; Malmström, Vivianne; Scheynius, Annika

doi:10.1111/j.1398-9995.2009.02266.x

Cited by 17 publications

(21 citation statements)

References 30 publications

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“…Understanding how the allergic response might change during pregnancy is critical if we are to elucidate how maternal disease impacts on fetal immune system development. A Th2-biased response to allergen seems to be retained in pregnancy: 1) pollen allergic women with detectable pollen-specific IgE have a Th2-skewed response to pollen allergens (Timothy grass/birch) [44]; and 2) allergenspecific and mitogen-induced IFN-γ decreases during pregnancy in atopic and nonatopic women, whereas allergen-specific IL-13 declines in nonatopic women only [45]. The relative blood eosinophilia that characterizes allergy also occurs in asthmatic pregnant women despite an apparent decline in eosinophil numbers during pregnancy [46].…”

Section: Impact Of Maternal Allergy On Immune Function During Pregnancymentioning

confidence: 99%

The Hygiene Hypothesis Revisited: Role of Materno-Fetal Interactions

Thornton

Macfarlane

Holt

2010

Curr Allergy Asthma Rep

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For 20 years, the hygiene hypothesis has dominated attempts to explain the increasing prevalence of allergic disease. A causal link between maternal innate immune response during pregnancy and disease protection in the offspring was recently demonstrated. Central to this was a systemically diffused signal that downregulated Toll-like receptor expression in placental tissues. Herein we develop the hypothesis that maternal systemic regulatory mechanisms operational during pregnancy could impact allergic disease risk of the offspring, depending on the type of inflammatory response from which they originate. Classic microbial-derived, mild, subacute inflammation provides a protective signal, whereas allergic inflammation provides a negative one. Mild, subacute inflammation of pregnant women leads to systemically diffused signals manifest in the gestation-associated tissues and by the fetus and newborn as a dampened inflammatory response. The converse is true if the mother has allergic inflammation during pregnancy. In both cases, these impact on development of the airways and of balanced immune function at birth and in early postnatal life. Thus, we seem to be at the dawn of a new incarnation of the hygiene hypothesis in which the pregnant woman's inflammatory response is crucial to determining the child's likelihood of developing allergic disease.

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Section: Impact Of Maternal Allergy On Immune Function During Pregnancymentioning

confidence: 99%

The Hygiene Hypothesis Revisited: Role of Materno-Fetal Interactions

Thornton

Macfarlane

Holt

2010

Curr Allergy Asthma Rep

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“…A recent study shows that the timothy- and birch-allergic mothers respond with increased proliferation and/or IL-4 production towards timothy and birch extract. However, cord blood mononuclear cell proliferation, phenotype of T cells, Foxp3(+) Tregs and B cells in response to the allergens are not affected by the allergic status of the mother [71]. Fetal exposures have been investigated as risk factors of early life allergic disease, and it is showed that nTreg levels during pregnancy in venous blood samples vary in association with both dog and cat exposure and atopic status [72].…”

Section: Introductionmentioning

confidence: 99%

Subsets of regulatory T cells and their roles in allergy

et al. 2014

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In recent years, it is recognized that acquired immunity is controlled by regulatory T cell (Treg). Since fundamental pathophysiological changes of allergy are mainly caused by hyperresponsiveness of immune system to allergens that acquires after birth, Tregs likely play key roles in the pathogenesis of allergy, particularly during the sensitization phase. However, accumulated information indicate that there are several distinctive subtypes of Tregs in man, and each of them seems to play different role in controlling immune system, which complicates the involvement of Tregs in allergy. The aim of the present study is to attempt to classify subtypes of Tregs and summarize their roles in allergy. Tregs should include natural Tregs (nTreg) including inducible costimulator (ICOS)(+) Tregs, inducible/adaptive Tregs (iTreg), interleukin (IL)-10-producing type 1 Tregs (Tr1 cells), CD8(+) Tregs and IL-17-producing Tregs. These cells share some common features including expression of Foxp3 (except for Tr1 cells), and secretion of inhibitory cytokine IL-10 and/or TGF-β. Furthermore, it is noticeable that Tregs likely contribute to allergic disorders such as dermatitis and airway inflammation, and play a crucial role in the treatment of allergy through their actions on suppression of effector T cells and inhibition of activation of mast cells and basophils. Modulation of functions of Tregs may provide a novel strategy to prevent and treat allergic diseases.

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“…Many authors have already tried to find some indications of future allergy development in cord blood. The responsiveness of cord blood cells of high-and low-risk children to allergens was followed [3,4], and polyclonal G + /Gbacteria stimulation [5][6][7][8] was tested. The proportion of both Th1 and Th2 cytokines in cord blood of high-and low-risk infants was tested [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Impaired function of regulatory T cells in cord blood of children of allergic mothers

Hrdý

Kocourková

Prokešová

2012

Clinical and Experimental Immunology

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SummaryAllergy is one of the most common diseases with constantly increasing incidence. The identification of prognostic markers pointing to increased risk of allergy development is of importance. Cord blood represents a suitable source of cells for searching for such prognostic markers. In our previous work, we described the increased reactivity of cord blood cells of newborns of allergic mothers in comparison to newborns of healthy mothers, which raised the question of whether or not this was due to the impaired function of regulatory T cells (

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Maternal allergic disease does not affect the phenotype of T and B cells or the immune response to allergens in neonates

Abstract: Our results suggest that maternal allergic disease has no effect on the neonatal response to allergens or the phenotype of neonatal lymphocytes. The factors studied here could, however, still affect later development of allergy.

Cited by 17 publications

References 30 publications

The Hygiene Hypothesis Revisited: Role of Materno-Fetal Interactions

The Hygiene Hypothesis Revisited: Role of Materno-Fetal Interactions

Subsets of regulatory T cells and their roles in allergy

Impaired function of regulatory T cells in cord blood of children of allergic mothers

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