Maternal allergy acts synergistically with cigarette smoke exposure during pregnancy to induce hepatic fibrosis in adult male offspring

Allina, Jorge; Grabowski, Jacquelin; Doherty-Lyons, Shannon; Fiel, M. Isabel; Jackson, Christine E.; Zelikoff, Judith T.; Odin, Joseph A.

doi:10.3109/1547691x.2011.589412

Cited by 8 publications

(10 citation statements)

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“…Human studies suggest that multiple 'hits' and/or 'stressors' are required to cause NASH and that epigenetics may play a significant role [34,35]. Our earlier study by Allina et al [3]) supports the two-hit hypothesis by demonstrating that prenatal exposure to cigarette smoke followed by immune sensitization increased adult offspring susceptibility to liver disease. The current study also demonstrates that the effects of prenatal exposure to gutkha on adult offspring hepatic parameters are sex-dependent.…”

Section: Discussionsupporting

confidence: 52%

Prenatal Exposure to Gutkha, a Globally Relevant Smokeless Tobacco Product, Induces Hepatic Changes in Adult Mice

Lyons

Blum

Hoffman-Budde

et al. 2020

IJERPH

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Maternal exposures during pregnancy affect the onset and progression of adult diseases in the offspring. A prior mouse study indicated that maternal tobacco smoke exposure affects hepatic fibrosis in adult offspring. Gutkha, a broadly used smokeless tobacco (ST) product, is widely used by pregnant woman in many countries. The objective of this murine study was to evaluate whether oral maternal exposure to gutkha during pregnancy alters non-alcoholic fatty liver disease (NAFLD) in adult offspring: risk factors for the progression of NAFLD to cirrhosis in adults remain elusive. Buccal cavity ‘painting’ of pregnant mice with gutkha began on gestational days (GD) 2–4 and continued until parturition. Beginning at 12 weeks of age, a subset of offspring were transitioned to a high-fat diet (HFD). Results demonstrated that prenatal exposure to gutkha followed by an HFD in adulthood significantly increased the histologic evidence of fatty liver disease only in adult male offspring. Changes in hepatic fibrosis-related cytokines (interleukin (IL)-1b and IL-6) and in hepatic collagen mRNA expression were observed when comparing adult male offspring exposed to gutkha in utero to those not exposed. These findings indicate that maternal use of gutkha during pregnancy affects NAFLD in adult offspring in a sex-dependent manner.

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Section: Discussionsupporting

confidence: 52%

Prenatal Exposure to Gutkha, a Globally Relevant Smokeless Tobacco Product, Induces Hepatic Changes in Adult Mice

Lyons

Blum

Hoffman-Budde

et al. 2020

IJERPH

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“…Smoking has also been shown to have impact on various diseases and has been found to be associated with CCL2 polymorphism and their levels in patients of myocardial infarction [ 21 ]. Smoking can also hamper the development of organs in offspring [ 23 , 24 ]. However, the precise mechanism behind pathological changes induced by smoking in association with genetic markers is being debated.…”

Section: Discussionmentioning

confidence: 99%

CCL2 single nucleotide polymorphism of rs1024611 implicates prominence of inflammatory cascade by univariate modeling in Indian AMD

Sharma

Singh

et al. 2018

PLoS ONE

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BackgroundThe role of chemotactic protein CCL2/MCP-1 has been widely explored in age related macular degeneration (AMD) patients as well as animal models through our previous studies.AimAim of the study was to examine the association of another variance of CCL2, rs1024611 in pathophysiology of AMD.MethodsThis particular SNP has been found to be involved in inflammatory processes in various diseases. Total 171 subjects were recruited in the study with all demographic details by administering a standard questionnaire. SNP analysis was performed with TaqMan assay. Linear univariate and ANCOVA modeling was performed to show the interaction of rs1024611 with another SNP variant of CCL-2/CCR-2 (rs4586 and rs1799865) and impact of individual genotypes on CCL-2 expression in the context of AMD pathology.ResultsResults showed that both heterozygous (AG, p = 0.01) and homozygous (GG, p = 0.0001) genotypes are associated with AMD pathology. Allele frequency analysis showed that ‘G’ allele is frequent in AMD patients as compared to controls (p = 0.0001). Moreover, AMD patients who smoke were found to be associated with ‘AG’ genotype (p = 0.0145). Although, we did not find any significant interaction between the SNP variants by linear univariate analysis but results show the effect of ‘CT’ genotype on ‘TT’ genotype in rs4586 by considering rs1024611 as covariate.ConclusionBased on these results it is imperative that CCL2 mediated pathology may be associated with AMD.

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“…The risk of fetal congenital heart defects has been shown by two studies to be at least partially linked to exposure to maternal smoking in early pregnancy or to be directly linked to maternal smoking during pregnancy for some specific subtypes [39,40]. …”

Section: Diseases Caused By Smoking During Pregnancymentioning

confidence: 99%

Smoking and Pregnancy — A Review on the First Major Environmental Risk Factor of the Unborn

Mund

Louwen

Klingelhoefer

et al. 2013

IJERPH

141

104

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Smoking cigarettes throughout pregnancy is one of the single most important avoidable causes of adverse pregnancy outcomes and it represents the first major environmental risk of the unborn. If compared with other risk factors in the perinatal period, exposure to tobacco smoke is considered to be amongst the most harmful and it is associated with high rates of long and short term morbidity and mortality for mother and child. A variety of adverse pregnancy outcomes are linked with cigarette consumption before and during pregnancy. Maternal prenatal cigarette smoke disturbs the equilibrium among the oxidant and antioxidant system, has negative impact on the genetic and cellular level of both mother and fetus and causes a large quantity of diseases in the unborn child. These smoking-induced damages for the unborn offspring manifest themselves at various times in life and for most only a very limited range of causal treatment exists. Education, support and assistance are of high importance to decrease maternal and fetal morbidity and mortality, as there are few other avoidable factors which influence a child’s health that profoundly throughout its life. It is imperative that smoking control should be seen as a public health priority.

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Maternal allergy acts synergistically with cigarette smoke exposure during pregnancy to induce hepatic fibrosis in adult male offspring

Cited by 8 publications

References 44 publications

Prenatal Exposure to Gutkha, a Globally Relevant Smokeless Tobacco Product, Induces Hepatic Changes in Adult Mice

Prenatal Exposure to Gutkha, a Globally Relevant Smokeless Tobacco Product, Induces Hepatic Changes in Adult Mice

CCL2 single nucleotide polymorphism of rs1024611 implicates prominence of inflammatory cascade by univariate modeling in Indian AMD

Smoking and Pregnancy — A Review on the First Major Environmental Risk Factor of the Unborn

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