Maternal and fetal benefits of DHA supplementation during pregnancy

Hubinont, Corinne; Savoye, Thomas

doi:10.15761/jpr.1000103

Cited by 7 publications

(6 citation statements)

References 51 publications

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“…However, consumption of omega-3 fatty acids remains low particularly in pregnant and lactating women [55]. This is of relevance considering the vital roles of DHA in neurodevelopment, visual development, and neuroinflammation [56]. Moreover, pregnancy syndromes such as gestational diabetes and preeclampsia have also been associated with altered maternal omega-3 status and placental omega-3 metabolism [57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Multiple Micronutrients and Docosahexaenoic Acid Supplementation during Pregnancy: A Randomized Controlled Study

et al. 2020

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Maternal dietary intake during pregnancy needs to meet increased nutritional demands to maintain metabolism and to support fetal development. Docosahexaenoic acid (DHA) is essential for fetal neuro-/visual development and in immunomodulation, accumulating rapidly within the developing brain and central nervous system. Levels available to the fetus are governed by the maternal diet. In this multicenter, parallel, randomized controlled trial, we evaluated once-daily supplementation with multiple micronutrients and DHA (i.e., multiple micronutrient supplementation, MMS) on maternal biomarkers and infant anthropometric parameters during the second and third trimesters of pregnancy compared with no supplementation. Primary efficacy endpoint: change in maternal red blood cell (RBC) DHA (wt% total fatty acids) during the study. Secondary variables: other biomarkers of fatty acid and oxidative status, vitamin D, and infant anthropometric parameters at delivery. Supplementation significantly increased RBC DHA levels, the omega-3 index, and vitamin D levels. Subscapular skinfold thickness was significantly greater with MMS in infants. Safety outcomes were comparable between groups. This first randomized controlled trial of supplementation with multiple micronutrients and DHA in pregnant women indicated that MMS significantly improved maternal DHA and vitamin D status in an industrialized setting—an important finding considering the essential roles of DHA and vitamin D.

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Section: Discussionmentioning

confidence: 99%

Multiple Micronutrients and Docosahexaenoic Acid Supplementation during Pregnancy: A Randomized Controlled Study

et al. 2020

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“…Minyak ikan merupakan sumber gizi omega-3 asam lemak tak jenuh ganda atau long-chain polyunsaturated fatty acids (LCPUFA), khususnya eicosapentaenoic acid (EPA, C20:5 n-3) dan docosahexaenoic acid (DHA, C22:6 n-3) yang sangat penting bagi kesehatan manusia (Félix-Soriano et al, 2021). Asupan EPA dan DHA yang cukup dapat mengurangi morbiditas penyakit kardiovaskular, meningkatkan kekebalan, mencegah tengkes, meningkatkan perkembangan kognitif, mencegah stres, kematian prenatal, dan kelahiran prematur selama kehamilan (Hubinont & Savoye, 2017;Meng et al, 2021).…”

Section: Pendahuluanunclassified

Peningkatan stabilitas oksidatif minyak mata tuna dengan metode purifikasi dan penambahan natural astaxanthin (NAst)

Nurmaida,

Ibrahim,

Trilaksani

2024

JPHPI

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Minyak ikan merupakan sumber nutrisi asam lemak tak jenuh ganda, khususnya eicosapentaenoic acid (EPA, C20:5 n-3) dan docosahexaenoic acid (DHA, C22:6 n-3) yang bermanfaat bagi kesehatan manusia. Mata tuna mengandung DHA yang tinggi dan unggul, sehingga dapat diolah menjadi minyak mata tuna. Kekurangan minyak mata tuna adalah mudah mengalami kerusakan oksidatif. Astaxanthin sebagai pigmen karotenoid memiliki aktivitas antioksidan kuat dan menghambat peroksidasi lipid penyebab kerusakan oksidatif. Tujuan penelitian ini menentukan konsentrasi terbaik penambahan astaxanthin pada minyak mata tuna hasil permurnianPemurnian minyak mata tuna dilakukan melalui netralisasi dengan NaOH 16oBe, dilanjutkan dengan bleaching menggunakan magnesol 5%. Minyak mata tuna hasil pemurnian, dicampur dengan astaxanthin kulit udang pada konsentrasi berbeda, yaitu 0; 0,2: 0,4: dan 0,6%. Parameter yang dianalisis meliputi asam lemak bebas, bilangan peroksida, bilangan p-anisidin, dan total oksidasi. Hasil penelitian menunjukkan bahwa purifikasi dengan netralisasi NaOH 16oBe dan bleaching magnesol 5% memiliki nilai asam lemak bebas 0,33±0,08%, bilangan peroksida 4,12±0,82 meq/kg, p-Anisidin 2,83±0,22 meq/kg, dan total oksidasi 11,08±1,62 meq/kg. Astaxanthin memiliki nilai IC50 14,14 ppm. Perlakuan penambahan astaxanthin terbaik adalah konsentrasi 0,6% dengan nilai asam lemak bebas 1,03±0,05%, bilangan peroksida 8,08±0,14 meq/kg, bilangan p-Anisidin 9,12±0,02 meq/kg; dan total oksidasi 25,29±0,31 meq/kg terkecil selama 60 hari penyimpanan. Purifikasi dan penambahan natural astaxanthin mampu memperbaiki kualitas mutu dan stabilitas minyak mata tuna selama penyimpanan.

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“…12 Reduced levels of DHA in mothers are associated with an increased risk of gestational diabetes, preeclampsia, intrauterine fetal growth restriction, postpartum depression, and preterm labor. 13 Iodine is important for thyroid hormone synthesis and evidence suggest that thyroid can modulate immune response.…”

Section: Maternal Nutritionmentioning

confidence: 99%

Enhancement of Immunity and Health in Neonates and Infants

Singh

Kaur

Gupta

et al. 2021

Journal of Neonatology

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Immunity is protective mechanism of the body against infection, diseases, and cancers. The stronger the immunity is the healthier we are. With increasing environmental change worldwide, increase of new emerging diseases and infection over last few decades, it has become imperative to move toward prevention more than the treatment. The immune mechanism in pediatric population especially neonates and infants is much different than adults and is yet evolving. The development of immunity starts in utero and is dependent on several factors. The various efforts to improve immunity and health should start from antenatal period focusing on overall health and nutrition of mother. Maternal nutrition, antenatal steroids, and delayed cord clamping are helpful in decreasing various neonatal morbidities which include respiratory distress syndrome, sepsis, necrotizing enterocolitis, intraventricular hemorrhage, and mortality. After birth during initial 6 months, exclusive breastfeeding, growth monitoring, primary immunization, developmentally supportive care, and care of infections are of utmost importance. After 6 months of age, a balanced approach toward introduction of complementary feeding, care of micronutrients, optimal environment, and inclusion of immunity enhancing foods in diet may have considerable benefits.

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Maternal and fetal benefits of DHA supplementation during pregnancy

Cited by 7 publications

References 51 publications

Multiple Micronutrients and Docosahexaenoic Acid Supplementation during Pregnancy: A Randomized Controlled Study

Multiple Micronutrients and Docosahexaenoic Acid Supplementation during Pregnancy: A Randomized Controlled Study

Peningkatan stabilitas oksidatif minyak mata tuna dengan metode purifikasi dan penambahan natural astaxanthin (NAst)

Enhancement of Immunity and Health in Neonates and Infants

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