Maternal and Fetal IGF-I and IGF-II Levels, Fetal Growth, and Gestational Diabetes

Luo, Zhong‐Cheng; Nuyt, Anne‐Monique; Delvin, Edgard; Audibert, François; Girard, Isabelle; Shatenstein, Bryna; Cloutier, Anik; Cousineau, Jean-Michel; Djemli, Anissa; Deal, Cheri; Lévy, Émile; Wu, Yuquan; Julien, Pierre; Fraser, William D.

doi:10.1210/jc.2011-3296

Cited by 67 publications

(75 citation statements)

References 31 publications

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“…One study showed that IGF-2 levels were higher in cord serum of offspring of diabetic mothers but did not correlate with birth weight [46]. Another showed that cord blood IGF-2 levels did not vary between mothers with and without diabetes but that IGF-2 was weakly correlated with birth weight and placental weight [47]. Both studies found a positive relationship between IGF-1 and birth weight and that infants of diabetic mothers had greater IGF-1 levels [46,47].…”

Section: Studies Examining Igf-2 Weight and Adipositymentioning

confidence: 99%

The Relationship of Insulin-Like Growth Factor 2 to Fetal Growth and Adiposity

Kadakia

Josefson²

2016

Horm Res Paediatr

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Insulin-like growth factor 2 (IGF-2) is necessary for adequate human growth. Overexpression of the IGF2 gene is associated with fetal overgrowth and may play a role in the intrauterine programming of adipose tissue. As obesity in children is a major public health problem associated with early onset of comorbid metabolic diseases, identifying early life markers of obesity may serve as useful tool for counseling and implementation of preventive efforts before obesity develops. The relationship between IGF-2 and body composition is an emerging field of study and existing data are conflicting. In this review, we discuss the IGF2 gene and its function, highlight the proposed mechanisms for the effects of IGF-2 on adiposity, and examine the current literature studying the relationships between IGF-2 levels, changes within the IGF2 gene, weight, and adiposity. With additional study, IGF-2 may emerge as a useful marker of future obesity risk in infants.

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Section: Studies Examining Igf-2 Weight and Adipositymentioning

confidence: 99%

The Relationship of Insulin-Like Growth Factor 2 to Fetal Growth and Adiposity

Kadakia

Josefson²

2016

Horm Res Paediatr

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“…Although the values of IGF-1 did not differ in mothers with DM (T1DM and T2DM) and normal mothers before and throughout pregnancy, IGF-1 concentration in cord serum of offspring born to diabetic mothers were significantly higher than of those of normal mothers [33]. Luo et al have shown that maternal and fetal IGF-1 levels were significantly higher in gestational diabetic than in nondiabetic pregnancies and that higher maternal at mid and late gestation appear strongly predictive of LGA birth [34]. Insulin growth factor-1 regulates amino acids transport in the placenta.…”

Section: Potential Mechanisms For Excessive Fetal Growthmentioning

confidence: 99%

“…Increased levels of IGF-1 contribute to the upregulation of placental amino-acid transporters resulting in elevated fetal amino acid levels in GDM [35]. Nevertheless, the association between maternal levels of IGF-1 and size at birth are inconsistent [34,[36][37][38]. It has been shown that cord blood IGF-1 levels are higher in LGA infants than in the AGA infants of non diabetic mothers [36] and high IGF-I levels are related to insulin resistance [39].…”

Section: Potential Mechanisms For Excessive Fetal Growthmentioning

confidence: 99%

Long-Term Metabolic Effects of High Birth Weight: A Critical Review of the Literature

et al. 2014

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Recent studies in USA, Europe, and across the world have revealed a continuous increase of mean birth weight in the last 2 decades. Strong evidence exists from several studies indicating that individuals born with a low birth weight are more likely to present cardiometabolic complications in later life. So far, the long-term consequences of high birth weight have not been clearly defined. This review examines the role of high birth weight on the development of cardiometabolic consequences (obesity, body composition, type 2 diabetes mellitus, and cardiovascular disease) in childhood and adulthood. The majority of the studies show that high BW is associated with an increased risk for obesity. To a certain extent high birth weight affects diseases of the heart and circulatory, but does not constitutes a risk for the development of type 2 diabetes mellitus in the general population. Maternal glycemia and the subsequent fetus hyperinsulinemia appear to be the key component for increased fetal growth. With the increase in incidence of diabetes mellitus and obesity over the years, the number of high birth weight infants is likely to increase. The elucidation of the relationship between high birth weight and the cardiometabolic disorders will be particularly important.

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“…10 On the other hand, IGF-I levels (but not IGF-II) are higher in fetuses with weights above the mean for gestational age. 11 IGF-binding proteins (IGFBPs) are inhibitors of IGF actions on metabolism and growth. 12 Currently, there are six named IGFBPs that can complex with both IGF-I and IGF-II.…”

Section: Introductionmentioning

confidence: 99%

Insulin-like growth factor-binding protein 1 and 7 concentrations are lower in obese pregnant women, women with gestational diabetes and their fetuses

Lappas

2014

J Perinatol

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Maternal and Fetal IGF-I and IGF-II Levels, Fetal Growth, and Gestational Diabetes

Abstract: Higher maternal IGF-I (but not IGF-II) levels at mid- and late gestation may indicate greater placental and fetal growth. IGF-I (but not IGF-II) may be implicated in fetal hypertrophy in gestational diabetes.

Cited by 67 publications

References 31 publications

The Relationship of Insulin-Like Growth Factor 2 to Fetal Growth and Adiposity

The Relationship of Insulin-Like Growth Factor 2 to Fetal Growth and Adiposity

Long-Term Metabolic Effects of High Birth Weight: A Critical Review of the Literature

Insulin-like growth factor-binding protein 1 and 7 concentrations are lower in obese pregnant women, women with gestational diabetes and their fetuses

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