Maternal and fetal insulin-like growth factors and their binding proteins in the second and third trimesters of human pregnancy

Langford, Kate; Nicolaides, Kypros H.; Miell, John P.

doi:10.1093/humrep/13.5.1389

Cited by 96 publications

(77 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Receptors for IGF-I are found in various tissues early in gestation (3), and fetal tissues seem to have enhanced sensitivity to IGF-I compared with later in life (4). Using cordocenteses, it has been possible to determine the "normal" range of IGF-I in fetal serum and to define a positive correlation between serum concentration of IGF-I and gestational age (5)(6)(7)(8)(9)(10). IGF-I levels are similar in arterial and venous cord serum, suggesting a fetal origin (1).…”

mentioning

confidence: 99%

The Role of Maternal Factors, Postnatal Nutrition, Weight Gain, and Gender in Regulation of Serum IGF-I among Preterm Infants

et al. 2005

View full text Add to dashboard Cite

mentioning

confidence: 99%

The Role of Maternal Factors, Postnatal Nutrition, Weight Gain, and Gender in Regulation of Serum IGF-I among Preterm Infants

et al. 2005

View full text Add to dashboard Cite

“…It is known that maternal IGFBP-1 and foetal IGFBP-2 and IGFBP-3 concentrations increase during pregnancy and that the level of IGFBP-1 is higher in foetal and cord blood than in adults [26,27]. In a preliminary assessment, however, we could not find any correlation between the conventionally assayed IAA levels and IGFBP-1 or IGFBP-3 concentrations in the cord blood of normal newborn infants (Ronkainen et al unpublished observation).…”

Section: Discussionmentioning

confidence: 55%

Pregnancy induces nonimmunoglobulin insulin-binding activity in both maternal and cord blood serum

Ronkainen

Hämäläinen

Koskela

et al. 2001

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYTo evaluate whether pregnancy has any effect on insulin antibody levels and to test the concordance between a conventional radioimmunoassay and a new microassay for the detection of insulin antibodies, insulin antibodies were analysed in 104 mothers in early pregnancy and at delivery and in their newborn infants. Thirty-eight of the mothers had type 1 diabetes. The concordance between the assays was high in the samples taken in early pregnancy (95%), but substantially lower in the samples taken at delivery (40%) and in the cord blood samples (68%). A considerable proportion of the mothers at delivery, especially the unaffected mothers (71%), and the newborn infants of the unaffected mothers (32%) were positive for insulin antibodies in the conventional assay but not in the microassay. Insulin antibody levels increased in the mothers, significantly so in the unaffected mothers (P , 0´001), during pregnancy in the conventional assay, whereas in the microassay they decreased significantly (P , 0´01) in affected mothers and remained negative in the unaffected mothers. Since immune complexes are precipitated with protein A specific for IgG in the microassay and with polyethylene glycol lacking specificity for immunoglobulins in the conventional assay, our data indicate that insulin antibody levels decrease on average during pregnancy and that the increasing non-IgG anti-insulin activity observed in the conventional assay is induced by pregnancy and is present in both the maternal and the foetal circulation.

show abstract

“…IGFBP-I can cross intact endothelium and so may be involved in the delivery of IGF-I to the tissues (Holmes et al 2000). IGFBP-I is known to increase rapidly in early human pregnancies before reaching a peak at 12-13 weeks then remaining elevated until term at 40 weeks (Langford et al 1998). From days 89 until 108 of pregnancy, IGFBP-I increased two-fold in both shorn and unshorn twin-bearing ewes and rem ained raised throughout the remaining study period.…”

Section: Discussionmentioning

confidence: 99%

Birth weight effect in twin‐born lambs from mid‐pregnancy shearing is associated with changes in maternal IGF‐I concentration

Jenkinson¹,

Kenyon

Blair

et al. 2009

New Zealand Journal of Agricultural Research

View full text Add to dashboard Cite

A number of studies have shown an increase in the birth weight of lambs in response to mid pregnancy shearing. The present study sought to determine whether the birth weight effect of midpregnancy shearing is mediated through changes in maternal insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-I (IGFBP-I) concentrations. Single-and twin-bearing ewes from three genetically divergent IGF-I lines were either left unshorn or shorn at a mean day 90 of pregnancy (P90). Maternal plasma concentrations of IGF-I and IGFBP-I were measured at P89, P108 Shearing increased the birth weight of twin lambs by over 350 g (P < 0.05) without having any effect on singleton birth weight. The increased birth weight of twin lambs born to shorn ewes was associated with a decline in maternal plasma IGF-I concentration (P < 0.05) from P108 toP136. Low IGF-I line ewes had lower (P < 0.001) plasma IGF-I than high IGF-I line ewes at each stage measured but higher plasma IGFBP-I at P89 and P108. Birth weights were higher in lambs born to low IGF-I line ewes than in those born to high IGF line ewes.These results suggest that the difference in birth weight between twin lambs from shorn and unshorn dams was mediated through a decline in maternal plasma IGF-I concentrations in late pregnancy. In support of previous studies, there was an inverse relationship between IGF-I selection line and lamb birth weight.

show abstract

Maternal and fetal insulin-like growth factors and their binding proteins in the second and third trimesters of human pregnancy

Cited by 96 publications

References 24 publications

The Role of Maternal Factors, Postnatal Nutrition, Weight Gain, and Gender in Regulation of Serum IGF-I among Preterm Infants

The Role of Maternal Factors, Postnatal Nutrition, Weight Gain, and Gender in Regulation of Serum IGF-I among Preterm Infants

Pregnancy induces nonimmunoglobulin insulin-binding activity in both maternal and cord blood serum

Birth weight effect in twin‐born lambs from mid‐pregnancy shearing is associated with changes in maternal IGF‐I concentration

Contact Info

Product

Resources

About