Maternal and Fetal Outcomes among Pregnant Women with Diabetes

Gojnić, M; Todorović, Jovana; Stanisavljević, Dejana; Jotić, Aleksandra; Lukić, Ljiljana; Miličić, Tanja; Lalić, Nebojša; Lalić, Katarina; Stoiljković, Milica; Stanisavljević, Tamara; Stefanović, Aleksandar; Stefanović, Katarina; Vrzić-Petronijević, Svetlana; Petronijević, Miloš; Terzić-Šupić, Zorica; Macura, Maja; Perović, Milan; Babic, Sandra; Piperac, Pavle; Jovanovic, Marija; Parapid, B.; Doklestic, Krisitna; Cerovic, Radmila; Đurašević, Siniša; Dugalić, Stefan

doi:10.3390/ijerph19063684

Cited by 14 publications

(10 citation statements)

References 37 publications

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“…First, this study was not able to access values for maternal BMI, before and after pregnancy, underlying disease, and obstetric complications such as gestational diabetes or pregnancy associated hypertension, and family income level, lifestyle factors including physical activity, smoking, and diet, which can affect term neonatal birth weight. [30][31][32][33] However, to avoid the influence of complicated pregnancies, we did not include births at 37 weeks' gestation because complicated pregnancies are more likely delivered as soon as they reach 37 weeks' gestation. More qualified national birth registry may be needed to improve not only for the study but also for the maternal-neonatal healthcare policies in the future.…”

Section: Discussionmentioning

confidence: 99%

Advanced parental age is an independent risk factor for term low birth weight and macrosomia

et al. 2022

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We aimed to investigate association between parental age and the risks of term low birth weight and macrosomia. This was a retrospective cohort study using a national database including 2,245,785 term singleton live births with complete parental age data. Old parental age was defined as 35 years or older. Odd ratios (OR) for term low birth weight and macrosomia were analyzed using univariate and multivariate logistic regression analysis. Neonatal sex, maternal occupation, parity, nationality, age, and paternal age were significant factors of term low birth weight and macrosomia, in univariate analysis. In multivariate analysis, old maternal age (≥35 years old) showed increased odds of term low birth weight and macrosomia (aOR = 1.122, 95% CI: 1.083 –1.162; and aOR = 1.166, 95% CI: 1.143 – 1.189, respectively). Similarly, old paternal age (≥35 years old) showed increased odds of term low birth weight and macrosomia (aOR = 1.090, 95% CI: 1.058 –1.122; and aOR = 1.101, 95% CI: 1.083 – 1.119, respectively). Maternal education that lasted more than 12 years had reduced odds of term low birth weight and macrosomia (OR = 0.817, 95% CI: 0.792 –0.842; and OR = 0.894, 95% CI: 0.879 – 0.91, respectively). Paternal education that lasted more than 12 years also had reduced odds of term low birth weight and macrosomia (OR = 0.865, 95% CI: 0.84 –0.892; and OR = 0.897, 95% CI: 0.881 – 0.913, respectively). This study suggests that not only maternal age but also paternal age are significantly associated with term low birth weight and macrosomia. In addition, parental education levels are also associated with term low birth weight and macrosomia.

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Section: Discussionmentioning

confidence: 99%

Advanced parental age is an independent risk factor for term low birth weight and macrosomia

et al. 2022

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“…During the examined period, the total number of live births in Belgrade was 196,987, and the prevalence of diabetes in pregnancy was 3.4%, with the total prevalence of pre-gestational diabetes of 0.7% and overall prevalence of GDM of 2.7%. The prevalence of diabetes in pregnancy and factors associated with it are described elsewhere [ 12 ]. Almost four fifths of the women with diabetes had GDM (5281—78.4%), just under one fifth (1318—19.6%) had T1DM, while 138 women (2.0%) had T2DM.…”

Section: Resultsmentioning

confidence: 99%

Trends of the Prevalence of Pre-gestational Diabetes in 2030 and 2050 in Belgrade Cohort

Dugalić

Petronijević

Vasiljević

et al. 2022

IJERPH

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The aim of this study was to analyze the trends in diabetes in pregnancy in Belgrade, Serbia for the period of the past decade and forecast the number of women with pre-gestational diabetes for the years 2030 and 2050. The study included the data on all pregnant women with diabetes from the registry of the deliveries in Belgrade, by the City Institute of Public Health of Belgrade, Serbia for the period between 2010 and 2020 and the published data on the deliveries on the territory of Belgrade. During the examined period the total number of live births in Belgrade was 196,987, and the prevalence of diabetes in pregnancy was 3.4%, with the total prevalence of pre-gestational diabetes of 0.7% and overall prevalence of GDM of 2.7%. The average age of women in our study was significantly lower in 2010 compared to 2020. The forecasted prevalence of pre-gestational diabetes among all pregnant women for 2030 is 2% and 4% for 2050 in our cohort. Our study showed that the prevalence of pre-gestational diabetes has increased both among all pregnant women and among women with diabetes in pregnancy in the past decade in Belgrade, Serbia and that it is expected to increase further in the next decades and to further double by 2050.

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“…For only 6 of the 14 studies, data for women with pre-existing diabetes (Type 1 or Type 2) were available and 24 out of 234 (10.2%) women ( Supplementary data, Table S2 ). In the general population, women with pre-existing diabetes are at a greater risk of pregnancy complications including birth defects, preeclampsia and preterm birth [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy in women on chronic dialysis in the last decade (2010–2020): a systematic review

Baouche

Jaı̈s

Meriem

et al. 2022

Clinical Kidney Journal

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Background Pregnant women with end-stage renal disease on chronic dialysis are at a high risk of maternal and foetal complications. Over the years, the prognosis of their pregnancies has improved with advances in dialysis treatments and maternal and neonatal care. We conducted this systematic review to examine the recent data on maternal and foetal outcomes in pregnant women with end-stage renal failure on chronic dialysis over the last decade. Methods We made a systematic review of studies on pregnant women on chronic dialysis published between January 1st, 2010, and December 31st, 2020. We searched the following electronic databases: Medline via PubMed, Embase and the Cochrane Library, with search strategies for each database. We checked the titles and abstracts identified by the search equation, and two independent reviewers assessed the articles retrieved. For each study, the two reviewers separately recorded the data from each selected article on a standardised data extraction form. For each article, we recorded relevant general information on the study, patient demographic characteristics, dialysis schedule, pregnancy complications and outcomes, maternal complications, and foetal and neonatal outcomes. Results The literature search yielded 1668 potentially relevant abstracts. After reviewing the titles, abstracts, and full text, we identified 14 studies according to the inclusion criteria. All studies were observational, 9 of them were retrospective and 8 were from the single-centre experience. The total number of women included in these studies was 2364 (range 8 to 2008) and the total number of pregnancies was 2754 (range 8 to 2352). The patients’ ages ranged from 15 to 45 years. Obesity was observed in 808 (34.2%) women and ranged from 1 to 778. Haemodialysis was the predominant modality with 2551 (92.6%) pregnancies and 203 (7.4%) on peritoneal dialysis. Overall, 68 out of 402 (16.9%) spontaneous miscarriages, 21 out of 402 (5.2%) therapeutic abortions and 26 (8.3%) stillbirths among 313 (stillbirths and live births) were recorded. The mean or median gestational age at delivery ranged from 25.2 to 36 weeks. The main maternal complications were preeclampsia 11.9%, hypertension 7.7%, and anaemia 3.9%. Live births represented 287 (71.4%) out of 402 pregnancies, birth weight ranged from 590 g to 3500 g and preterm birth was the main, most common complication in all studies, ranging from 50% to 100%. Intrauterine growth restriction was present in 5.9% and small-for-gestational-age was reported in 18.9% of neonates. There were 22 (7.6%) neonatal deaths among 287 live births and 48 (15.3%) perinatal deaths among 313 total births (stillbirths and live births). Conclusions Presumably, considering the increase in the number of publications and the total number of pregnancies reported therein, the frequency of pregnancy in patients with end-stage chronic kidney disease treated by chronic dialysis has increased. However, the practice of treating pregnant women on dialysis differs significantly among countries. These findings highlight the need to standardise the definition of outcomes and healthcare for pregnant women on dialysis.

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Maternal and Fetal Outcomes among Pregnant Women with Diabetes

Cited by 14 publications

References 37 publications

Advanced parental age is an independent risk factor for term low birth weight and macrosomia

Advanced parental age is an independent risk factor for term low birth weight and macrosomia

Trends of the Prevalence of Pre-gestational Diabetes in 2030 and 2050 in Belgrade Cohort

Pregnancy in women on chronic dialysis in the last decade (2010–2020): a systematic review

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