Maternal and fetal outcomes of dengue fever in pregnancy: a large prospective and descriptive observational study

Brar, Rinnie; Sikka, Pooja; Suri, Vikas; Singh, Mini P.; Suri, Vanita; Mohindra, Ritin; Biswal, Manisha

doi:10.1007/s00404-020-05930-7

Cited by 34 publications

(43 citation statements)

References 27 publications

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“…30 When a mother does have a DENV infection while she is pregnant, babies may suffer from pre-term birth, low birth-weight, and foetal distress. 31…”

Section: Human-to-mosquito Transmissionmentioning

confidence: 99%

Dengue in India: An Overview

Prajapati¹,

Singh²,

Jain³

et al. 2022

Natl J Community Med

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Background: Dengue fever has become a major public health concern in our country, causing significant morbidity and mortality. Because there is no definite drug or commercially available vaccine for dengue, prevention is the only option. As a result, early reporting of dengue cases is required in order to implement preventive measures before the disease spreads to epidemic proportions. Therefore, healthcare providers should notify every dengue incident to local authorities in the current format, including the District Health Officer or Chief Medical Officer of district concerned and the Municipal Health Officer of municipality concerned every week (daily during the transmission period). Materials and Methods:The data on dengue (2015-2021 till Oct.) was available at the National Vector Borne Disease Control Programme under the Ministry of Health & Family Welfare, Government of India, and has been used in this paper. Results and discussion:During the last two decades (2000-2009 and 2010-2019), significant geographical spread of the dengue has been experienced in India with the repeated outbreaks, and an 11 fold increase in number of cases. Despite an increase in the incidence of dengue fever, the case fatality rate in India has decreased from 3.3% in 1996 to 0.4% in 2010 to 0.1% in 2019. Early diagnosis and timely referral play a critical role in bringing down Case Fatality Rate (CFR). Conclusion:Dengue is a manifestation arising from the process of increasing vector density and adaptation to human habitation, as well as human lifestyle transformation, unplanned developmental activities exacerbated by climate change.

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“…30 When a mother does have a DENV infection while she is pregnant, babies may suffer from pre-term birth, low birth-weight, and foetal distress. 31…”

Section: Human-to-mosquito Transmissionmentioning

confidence: 99%

Dengue in India: An Overview

Prajapati¹,

Singh²,

Jain³

et al. 2022

Natl J Community Med

View full text Add to dashboard Cite

show abstract

“… 12 , 13 , 15 , 16 , 17 , 18 , 19 , 20 , 21 It has also been reported that pregnant women infected with DENV are susceptible to increased disease severity and mortality. 18 , 19 , 20 , 22 , 23 , 24 , 25 Additionally, vertical transmission has been reported for DENV infection by detecting the virus genome and/or DENV-specific IgM in the fetal and cord blood at birth. 26 , 27 , 28 , 29 DENV infection has also been histologically detected in tissues of aborted fetuses aged 12 weeks old 28 and 29 weeks old.…”

Section: Introductionmentioning

confidence: 99%

Experimental evidence for a high rate of maternal-fetal transmission of dengue virus in the presence of antibodies in immunocompromised mice

et al. 2022

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“…After taking into account titles and abstracts, 852 articles were eliminated, leaving 68 articles for review and potential consideration in this study (Figure 1). Ultimately, 36 articles reporting on 39,632 DENV‐infected pregnant women were included in this meta‐analysis, 6–8,14–46 comprising 18 from Asia (mostly from India, n = 12), 15 from Latin America and 3 from Africa (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Maternal and foetal‐neonatal outcomes of dengue virus infection during pregnancy

Rathore¹,

Oberoi

Hilliard³

et al. 2022

Tropical Med Int Health

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Objective: Given that women of reproductive age in dengue-endemic areas are at risk of infection, it is necessary to determine whether dengue virus (DENV) infection during pregnancy is associated with adverse outcomes. The aim of this systematic review and meta-analysis is to investigate the consequences of DENV infection in pregnancy on various maternal and foetal-neonatal outcomes. Methods: A systematic literature search was undertaken using PubMed, Google Scholar, and Embase till December 2021. Mantel-Haenszel risk ratios were calculated to report overall effect size using random effect models. The pooled prevalence was computed using the random effect model. All statistical analyses were performed on MedCalc Software. Result: We obtained data from 36 studies involving 39,632 DENV-infected pregnant women. DENV infection in pregnancy was associated with an increased risk of maternal mortality (OR = 4.14 [95% CI, 1.17-14.73]), stillbirth (OR = 2.71 [95% CI, 1.44-5.10]), and neonatal deaths (OR = 3.03 [95% CI, 1.17-7.83]) compared with pregnant women without DENV infection. There was no significant statistical association established between maternal DENV infection and the outcomes of preterm birth, maternal bleeding, low birth weight in neonates, and risk of miscarriage. Pooled prevalences were 14.9% for dengue shock syndrome, 14% for preterm birth, 13.8% for maternal bleeding, 10.1% for low birth weight, 6% for miscarriages, and 5.6% for stillbirth. Conclusion: DENV infection in pregnant women may be associated with adverse outcomes such as maternal mortality, stillbirth, and neonatal mortality. Hence, pregnant women should be considered an at-risk population for dengue management programmes.

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Maternal and fetal outcomes of dengue fever in pregnancy: a large prospective and descriptive observational study

Cited by 34 publications

References 27 publications

Dengue in India: An Overview

Dengue in India: An Overview

Experimental evidence for a high rate of maternal-fetal transmission of dengue virus in the presence of antibodies in immunocompromised mice

Maternal and foetal‐neonatal outcomes of dengue virus infection during pregnancy

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