Maternal and Fetal Serum Copper Levels at Delivery

Schenker, J. G.; Jungreis, E.; Polishuk, W.Z.

doi:10.1159/000240463

Cited by 15 publications

(7 citation statements)

References 9 publications

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“…The results on plasma zinc and copper concentrations were in approximate agree ment with those of previous reports [4][5][6][7], although the zinc concentration in maternal plasma was not lower than in control plasma. The erythrocyte concentrations of CA isoen zymes and of SOD | were independent of the plasma concentrations of the trace elements.…”

Section: Resultssupporting

confidence: 91%

“…A number of studies have shown that there are unexplained disparities between maternal and newborn plasma/serum con centrations of zinc and copper at delivery [4][5][6][7], However, very few data on these trace elements in erythrocytes are available [8,9], and much remains to be clarified about their distributions in human blood during preg nancy. In the present study, we have investi gated these metals and compared the concen trations of CA-I, CA-II and SOD| in mater nal and cord blood at delivery.…”

Section: Introductionmentioning

confidence: 99%

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Distribution of Zinc and Copper in Maternal and Cord Blood at Delivery

et al. 1985

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For 17 normal births, the concentrations of trace metals (zinc and copper) and related metalloenzymes, i.e., carbonic anhydrase isoenzymes (CA-I and CA-II) and Cu₂Zn₂superoxide dismutase (SOD₁) were simultaneously determined in maternal and cord blood at delivery. Eleven healthy nonpregnant women served as controls. CA-I concentration in maternal erythrocytes was higher than in controls (p < 0.05), whereas the concentrations of both CA isoenzymes in cord erythrocytes were in the range of one seventh to one ninth of those in controls. On the other hand, the erythrocyte SOD₁ concentration was constant. A very low total zinc concentration was noted in cord erythrocytes, and this was due to the low concentrations of both CA isoenzymes. Total copper concentration in maternal erythrocytes was significantly lower than in controls (p < 0.05); in contrast, that in cord erythrocytes was significantly higher than in controls (p < 0.05). Thus, variations in erythrocyte copper concentrations are due to changes in other forms of copper (not SOD₁-derived). Copper concentration in maternal plasma was about three times higher than in controls, while copper concentration in cord plasma was less half of that in control plasma. Conversely, zinc concentration in cord plasma was significantly higher than in controls (p < 0.05). The concentrations of these metals in maternal erythrocytes and plasma were significantly different from the respective concentrations in cord erythrocytes and plasma. Likewise, the concentrations of these metals in maternal and cord erythrocytes contrasted with the corresponding concentrations in their plasma.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Distribution of Zinc and Copper in Maternal and Cord Blood at Delivery

et al. 1985

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“…Also in the fetus, almost all the copper is carried by ceruloplasmin [19]. The hypocupremia of the newborn is explained by a reduced ability of the immature fetal liver to synthesize ceruloplasmin [20].…”

Section: Coppermentioning

confidence: 99%

The Role of Calcium, Copper, Iron and Zinc in Preterm Delivery and Premature Rupture of Fetal Membranes

Kiilholma

Grönroos

Erkkola

et al. 1984

Gynecol Obstet Invest

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Maternal and cord blood samples were collected in 60 cases with or without rupture of membranes before and at term. Serum concentrations of calcium, copper, iron and zinc were determined by proton-induced X-ray emission. Maternal and cord serum cerulo-plasmin and maternal hemoglobin were also determined. Mothers with preterm delivery showed significantly lower hemoglobin values than those with delivery at term. Concentrations of calcium, iron and zinc were higher in cord than in maternal serum whereas maternal copper levels were higher than respective cord levels in all groups. The cord copper and ceruloplasmin and also their fetal/maternal ratios were significantly lower in the group with preterm premature rupture of fetal membranes (PROM) than in other groups. Maternal serum zinc and calcium were lower in preterm groups than in term groups. The study suggests a possible role of copper in preterm PROM and of zinc in the initiation of preterm labor, whereas calcium and iron do not seem to be involved in the etiology of prematurity or PROM.

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“…Studies on the trace element metabolism of the pregnant and lactating human body are largely limited to blood analyses (serum, plasma) or hair analyses that must, however, be considered problematical on the basis of results from animal experiments (75,114). Hence the number of investigations during the reproductive phase is small (11,29,35,99,100). Interactions found between the maternal and fetal trace element contents (35,77,98) are yet difficult to interpret.…”

Section: Trace Element Deficiency and Reproductionmentioning

confidence: 99%

A Comparative View on Trace Elements and Growth

Kirchgeßner¹,

Roth²,

Spoerl³

et al. 1977

Ann Nutr Metab

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The term ‘essentiality’ of trace elements is interpreted. The major human diseases due to trace element deficiency (Fe, Cu, Zn, Cr) are briefly considered. In growing animals the first clinical deficiency symptom most often is a growth retardation. In order to diagnose a deficient situation before the manifestation of clinical symptoms, model studies with growing animals are presented to show criteria that respond sensitively even to suboptimum intake of trace elements (Zn, Cu, Fe, Ni). Activity measurements of enzymes and hormones are found suitable. During the phase of reproduction, which is closely associated with growth, the trace element concentration in milk may provide an additional diagnostic means. In conclusion, the problems of diagnosing the supply status are discussed. A possibility for determination of the trace element requirement is indicated.

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Maternal and Fetal Serum Copper Levels at Delivery

Cited by 15 publications

References 9 publications

Distribution of Zinc and Copper in Maternal and Cord Blood at Delivery

Distribution of Zinc and Copper in Maternal and Cord Blood at Delivery

The Role of Calcium, Copper, Iron and Zinc in Preterm Delivery and Premature Rupture of Fetal Membranes

A Comparative View on Trace Elements and Growth

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