Maternal and neonatal micronutrient levels in newborns with CHD

Díllí, Dílek; Doğan, Nazan Neslihan; Örün, Utku Arman; Koç, Murat; Zencıroğlu, Ayşegül; Karademir, Selmin; Akduman, Hasan

doi:10.1017/s1047951117002372

Cited by 15 publications

(32 citation statements)

References 35 publications

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“…Few studies were conducted to investigate the association between maternal vitamin D level and risk of CHD in offspring. Similar to our results, Dilli et al 32 conducted a case control study to measure serum level of micronutrients (including vitamin D) in 108 neonates with CHD and their mothers. They found a significant decrease in vitamin D level in both neonates and their mothers compared to controls.…”

Section: Discussionsupporting

confidence: 86%

“…Few studies reported association between vitamin D level and specific CHD phenotype. Despite the difference in CHD phenotype classification, Dilli et al 32 found that maternal and neonatal vitamin D level were lower in truncal anomalies including truncus arteriosus, tetralogy of Fallot, and D-transposition of great arteries. In addition, Koster et al 33 reported that there was a significant association between maternal vitamin D status (deficient and moderate) and isolated group of congenital heart disease but not a complex one.…”

Section: Discussionmentioning

confidence: 99%

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Maternal vitamin D level and vitamin D receptor gene polymorphism as a risk factor for congenital heart diseases in offspring; An Egyptian case-control study

et al. 2019

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Vitamin D & vitamin D receptor (VDR) signaling play a very crucial role in early embryonic heart development. We construct this case-control study to investigate the association between maternal serum vitamin D level & VDR gene Fok1 polymorphism and risk of congenital heart defects (CHD) in offspring. Fifty mothers who had term neonates with CHD were considered as cases. Fifty age-comparable healthy mothers who had neonates without CHD were contemplated as controls. Maternal serum 25 hydroxyvitamin D [25(OH) D] level was tested using ELISA. Maternal VDR gene Fok1 polymorphism was analyzed using PCR-based RFLP-assay. There was a significant decrease in maternal vitamin D level ( P = 0.002) and a significant increase in vitamin D deficient status ( P = 0.007) among cases when compared to controls. VDR gene Fok1 genotypes distribution frequency were in accordance with Hardy Weinberg equilibrium (HW) among controls. A significant increase in VDR gene Fok1 F/f & f/f genotypes and f allele were observed in cases compared to controls with estimated odds ratio (95% confidence interval) & P -value of 3 (1–8) & P = 0.006, 11 (1–97) & P = 0.01 and 3 (2–6) & P = 0.001 respectively. There was a significant decrease in maternal vitamin D level in neonates with cyanotic CHD ( P = 0.000) compared to those with a cyanotic CHD while there was no significant difference in VDR Fok1 genotype ( P = 0.18) & allele ( P = 0.05) distribution between two groups. We concluded that maternal vitamin D deficiency and VDR gene Fok1 F/f, f/f genotype and f allele were associated with increased risk of CHD in offspring.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Maternal vitamin D level and vitamin D receptor gene polymorphism as a risk factor for congenital heart diseases in offspring; An Egyptian case-control study

et al. 2019

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“…In one study in Germany, maternal serum vitamin B 12 and holotranscobalamin (holoTC) concentrations at delivery were significantly correlated with cord blood holoTC concentrations ( p < 0.05) [18]. In contrast, findings from cross-sectional studies examining the associations between maternal and infant vitamin B 12 concentrations later in the postpartum period have been heterogeneous [35,36,37,38,39,40]. Maternal vitamin B 12 and holoTC concentrations were significantly correlated with infant vitamin B 12 concentrations in the first month (i.e., 2–30 days) postpartum in a study in Turkey [38].…”

Section: Introductionmentioning

confidence: 99%

Vitamin B12 Status in Pregnant Adolescents and Their Infants

et al. 2019

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Vitamin B12 deficiency has been associated with increased risk of adverse pregnancy outcomes. Few prospective studies have investigated the burden or determinants of vitamin B12 deficiency early in life, particularly among pregnant adolescents and their children. The objectives of this study were to determine the prevalence of vitamin B12 deficiency and to examine associations between maternal and neonatal vitamin B12 status in a cohort study of healthy pregnant adolescents. Serum vitamin B12 and folate concentrations were measured in adolescents at mid-gestation (n = 124; 26.4 ± 3.5 weeks) and delivery (n = 131; 40.0 ± 1.3 weeks), and in neonates at birth using cord blood. Linear regression was used to examine associations between maternal and neonatal vitamin B12 status. Although the prevalence of vitamin B12 deficiency (<148.0 pmol/L; 1.6%) in adolescents was low during pregnancy, 22.6% of adolescents were vitamin B12 insufficient (<221.0 pmol/L; 22.6%) at mid-gestation. Maternal vitamin B12 concentrations significantly decreased from mid-gestation to delivery (p < 0.0001), and 53.4% had insufficient vitamin B12 status at delivery. Maternal vitamin B12 concentrations (p < 0.001) and vitamin B12 deficiency (p = 0.002) at delivery were significantly associated with infant vitamin B12 concentrations in multivariate analyses, adjusting for gestational age, maternal age, parity, smoking status, relationship status, prenatal supplement use, pre-pregnancy body mass index, race, and intake of vitamin B12 and folate. Maternal vitamin B12 concentrations significantly decreased during pregnancy and predicted neonatal vitamin B12 status in a cohort of healthy pregnant adolescents.

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“…Consequently, this case-control study was carried out with the standardized time determined as after neonatal birth. Dilli et al reported that serum vitamin D levels in both mothers and neonates were relatively low, indicating that these ratios were effective in the pathogenesis of CHD (30).…”

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D consumption during pregnancy and neonatal congenital heart disease

et al. 2020

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Background and Aim: Interactions between genetic and environmental factors, including modifiable maternal nutrition and lifestyle, play a significant role in the pathogenesis of most congenital heart defects (CHD). This study was conducted to investigate the relationship between periconceptional maternal vitamin D status and the prevalence of CHD in offspring. Materials and Methods: This case-control study was conducted on 660 neonates referring to Masoumeh Hospital, Qom, Iran, from April 2016 onwards. The subjects were divided into two groups of CHD and healthy patients. The instrument applied to collect the necessary data was a research-made checklist including demographic data and risk factors related to the study, which was filled by mothers. Independent t-test and Chi-square test were used to analyze quantitative and qualitative variables, respectively. A logistic regression test was also utilized, and the p-value of less than 0.05was considered significant. Results: The mean age of mothers was obtained as 30 years in both groups. It was revealed that 94 (28.5%) and 159 (48.2%) of mothers in the case and control groups consumed Vitamin D in pregnancy. There was a significant difference between vitamin D intake and CHD in the two groups(p<0/001). The economic status of 53.3% of families with CHD patients was reported to be low. According to the results, 70.6% of mothers in the case group were highly educated. Conclusion: Based on the results, vitamin D consumption during pregnancy was associated with the reduction of neonatal CHD. Moreover, economic status was found as another risk factor affecting the development of neonatal CHD.

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Maternal and neonatal micronutrient levels in newborns with CHD

Abstract: We thought that high homocysteine and zinc levels and low vitamin D levels in mother-infant pairs might have a role in the aetiopathogenesis of CHD. Large-scale, prospective studies are needed to clarify the role of micronutrients in CHDs.

Cited by 15 publications

References 35 publications

Maternal vitamin D level and vitamin D receptor gene polymorphism as a risk factor for congenital heart diseases in offspring; An Egyptian case-control study

Maternal vitamin D level and vitamin D receptor gene polymorphism as a risk factor for congenital heart diseases in offspring; An Egyptian case-control study

Vitamin B12 Status in Pregnant Adolescents and Their Infants

Relationship between vitamin D consumption during pregnancy and neonatal congenital heart disease

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