Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study

Weisse, Karla; Winkler, Sylke; Hirche, Frank; Herberth, Gunda; Hinz, Denise; Bauer, Mario; Röder, Stefan; Rolle-Kampczyk, Ulrike; Bergen, Martin von; Olek, Sven; Sack, Ulrich; Richter, Thomas; Diez, Ulrike; Borte, Michael; Stangl, Gabriele I.; Lehmann, Irina

doi:10.1111/all.12081

Cited by 183 publications

(193 citation statements)

References 38 publications

(47 reference statements)

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“…38,45 Mullins et al, 52 though, found a decrease in peanut allergy in the third quartile (75-99.9 nmol/L) compared with the reference second quartile (50-74.9 nmol/L) but found no significant differences between the first or fourth quartiles compared with the reference quartile. The study by Weisse et al 50 showed a positive associ- …”

Section: Allergic Diseasementioning

confidence: 90%

“…Of the 5 studies that looked at regulatory T cells in cord blood, 3 found no associations. 28,62,63 Vijayendra Chary et al 64 found a positive relationship between cord blood 25(OH)D concentrations and regulatory T cell percentages, while Weisse et al 50 found a negative relationship with cord blood 25(OH)D, but not with maternal 25(OH)D as an exposure. Guven et al 62 and Romero et al 63 looked at a variety of other data points related to cord blood lymphocytes, focusing on T-helper cells, and found no correlation with cord blood 25(OH)D.…”

Section: Infectious Diseasementioning

confidence: 99%

“…The remaining 6 studies showed no association between maternal or cord blood 25(OH)D and atopic dermatitis. 30,35,41,43,45,50 One study did not report on the outcome. 37 While 7 studies listed clinician-diagnosed food allergies as one of their measured outcomes, 2 did not report data on this outcome, 35,37 and another was unable to assess allergies because of a small sample size.…”

Section: Allergic Diseasementioning

confidence: 99%

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Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review

et al. 2016

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Context: It is unclear how in utero vitamin D deficiency affects the extraskeletal health of children, despite the known risks for adverse pregnancy/birth outcomes. Objective: This systematic review seeks to assess the effect of in utero vitamin D exposure on childhood allergy and infection outcomes using the PRISMA guidelines. Data Sources: MEDLINE, Cochrane Library, and Web of Science databases were searched. Study Selection: Literature published through April 2015 was searched for studies reporting on the association between maternal pregnancy or cord blood vitamin D status and childhood allergy and infection. Data Extraction: Of 4175 articles identified, 43 studies met the inclusion criteria. They examined a wide variety of outcomes, using many different vitamin D cutoff values in their analyses. Data Synthesis: For most outcomes, results were inconsistent, although there appeared to be a protective effect between higher in utero vitamin D status and childhood lower respiratory tract infection (5 of 10 studies). Conclusions: More research is needed on childhood allergy and infection outcomes, and future studies should standardize outcome reporting, especially with regard to cutoff values for vitamin D concentrations. Evidence of a protective association between in utero vitamin D exposure and lower respiratory tract infection was found, while the other outcomes were either understudied or showed inconsistent results. PROSPERO registration no. CRD42013006156.

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Section: Allergic Diseasementioning

confidence: 90%

Section: Infectious Diseasementioning

confidence: 99%

Section: Allergic Diseasementioning

confidence: 99%

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Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review

et al. 2016

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“…In preliminary studies Vitamin D deficiency was associated with higher levels of IgE sensitization in children and adolescents (SHARIEF et al, 2011). However later studies demonstrated that high vitamin D levels in pregnancy and at birth may contribute to a higher risk for food allergy and therefore argues against vitamin D supplementation to protect against allergy (WEISSE et al, 2013).…”

Section: New Challenges and Futurementioning

confidence: 99%

Recent advances in food allergy

Alcocer

Cruz-Ares

López-Calleja

2016

Braz. J. Food Technol.

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SummaryFood allergy is a public health issue that has significantly increased worldwide in the past decade, affecting consumers' quality of life and making increasing demands on health service resources. Despite recent advances in many areas of diagnosis and treatment, our general knowledge of the basic mechanisms of the disease remain limited i.e., not at pace with the exponential number of new cases and the explosion of new technologies. Many important key questions remain: What defines a major allergen? Why do some individuals develop food allergies and others do not? Which are the environmental factors? Could the environmental factors be monitored through epigenetics or modified by changes in the microbiome? Can tolerance to food be induced? Why are some foods more likely to trigger allergies than others? Does the route and timing of exposure have any role on sensitization? These and many other related questions remain unanswered. In this short review some of these topics are addressed in the light of recent advances in the area.Keywords: Food allergy; Allergens; Tolerance; Sensitization; Treatment. ResumoA alergia alimentar é uma questão de saúde pública que tem aumentado significativamente na última década em todo o mundo, afetando a qualidade de vida dos consumidores e fazendo demandas crescentes sobre os recursos dos serviços de saúde. Apesar dos recentes avanços em muitas áreas de diagnóstico e tratamento, o nosso conhecimento geral dos mecanismos básicos da doença permanecem limitados, isto é, não avança no mesmo ritmo exponencial de novos casos e chegada de novas tecnologias. Muitas questões importantes permanecem: O que define um alérgeno principal? Por que algumas pessoas desenvolvem alergias alimentares e outras não? Quais são os fatores ambientais? Poderiam os fatores ambientais serem monitorados através de técnicas epigenéticas ou modificados por mudanças no microbioma? Poderia tolerância ao alimento ser induzida? Por que alguns alimentos são mais propensos a desencadear alergias do que outros? Será que a rota e tempo de exposição têm qualquer papel na sensibilização? Estas e muitas outras questões relacionadas permanecem sem resposta. Nesta breve revisão, alguns destes tópicos são abordados à luz dos recentes avanços na área.

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“…On one hand, allergies increased coinciding with vitamin D supplementation intervention programs to prevent rickets in childhood [32], and increased risk for asthma and food allergies has been reported among children receiving early vitamin supplementation [33]. In a recent German cohort study, it has been described that higher maternal 25(OH)D 3 results in a higher risk of food allergy sensitization at 2 years of age [34]. On the other hand, the vitamin D deficiency (VDD) hypothesis argues that inadequate vitamin D is responsible for the increase in allergic diseases.…”

mentioning

confidence: 99%

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

Luengo¹,

Song²

2013

J Aller Ther

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Effective primary preventions strategies aimed at reducing the onset of IgE sensitization are urgently needed as the incidence of childhood food allergy keeps increasing.Studies eliminating food allergens during pregnancy have failed to show reduction in the prevalence of long-term IgE-mediated food allergy in children, and recent data provides direct evidence supporting early oral exposure as a means of preventing development of allergy. Since effects on early immune programming may be more significant in utero, there has been increasing interest in the potential protective role of maternal dietary modifications on the development of FA in offspring.In this article, we will review the current knowledge from animal and clinical studies on the role of maternal dietary modification, mainly through supplementation with vitamins, polyunsaturated fatty acids and probiotics, for the prevention of food allergy. Besides, the potential role of some promising FA treatments like Chinese herbal formula FAHF-2 for the primary prevention of FA in offspring will be reviewed. be due to uncontrolled environmental factors, timing of introduction to PN and different study protocols and populations, as well as undefined co-factors in maternal diet such as microbes [18][19][20]. In addition, retrospective maternal recall of dietary intake during pregnancy (and or lactation), sometimes months or years later, may contain recall bias. At present, the standard practice for PNA and other food allergies is strict allergen avoidance. There is no clinical study reporting whether peanut allergic mother consumption of controlled low doses of peanut that do not trigger clinical reactions would prevent offspring peanut or other food allergies. The Potential of Maternal Dietary Modification for Prevention of Food AllergyOlga Maternal allergenic food consumption for preventing food allergy in offspring: Animal studiesIn recent years several studies in animal models have provided direct evidence supporting early oral exposure as a means of preventing development of allergy.Melkild et al. [21] showed that intraperitoneal immunization of naïve mice with ovalbumin and adjuvant (Al(OH) 3 ) during pregnancy and lactation significantly reduced the specific IgE response and increased the IgG2a response in their offspring. Moreover, the IgE suppression was stronger if maternal allergen exposure was during early pregnancy (3 days into pregnancy) compared to a late pregnancy exposure (17 days into pregnancy). The same group reported that the protective effect of maternal immunization was affected by the type of adjuvant used: while offspring from mothers immunized with OVA and either pertussis toxin (PT) or Al(OH) 3 showed reduced levels of OVA-specific IgE and IgG1 and increased levels of OVA-specific IgG2a antibodies, maternal immunization with CpG and OVA did not affect antibody responses in offspring [22]. However, whether this effect is dependent on the specific adjuvant and/or the route of exposure employed has to be further investigated. Le...

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Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study

Abstract: Our study demonstrates that high vitamin D levels in pregnancy and at birth may contribute to a higher risk for food allergy and therefore argues against vitamin D supplement to protect against allergy.

Cited by 183 publications

References 38 publications

Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review

Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review

Recent advances in food allergy

The Potential of Maternal Dietary Modification for Prevention of Food Allergy

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