Maternal and paternal occupational exposure to agricultural work and the risk of anencephaly

Lacasaña, Marina; Vázquez-Grameix, H; Borja-Aburto, Víctor Hugo; Blanco-Muñoz, Julia; Romieu, Isabelle; Aguilar-Garduño, Clemente; García, Ana M.

doi:10.1136/oem.2005.023333

Cited by 78 publications

(55 citation statements)

References 46 publications

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“…This supports other studies that reported an association between agricultural work and/or exposure to pesticides experienced by the father, or the mother, or both; and different adverse reproductive effects such as congenital malformations in general [23][24][25], cleft lip and palate [26][27], musculoskeletal defects [28], limb reduction defects [29][30], and central nervous system defects [31][32][33]. Environmental or occupational exposure to pesticides may cause alterations in the male gametes prior to conception, as well as embryonic damage or feto-placental complex.…”

Section: Discussionsupporting

confidence: 77%

Paternal occupational exposures and the risk of congenital malformations — A case-control study

El-Helaly¹,

Abdel-Elah²,

Haussein³

et al. 2011

International Journal of Occupational Medicine and Environmental Health

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Objectives: This study examined the association between certain paternal occupational exposures during the periconceptional period and the risk of congenital malformations. Materials and Methods: A case-control study was carried out from December 2009 to April 2010; on 242 congenital malformation cases and 270 controls. Paternal occupational exposure to certain workplace hazards was assessed by a detailed questionnaire to evaluate the occupational exposure for both fathers and mothers including pesticides, solvents, welding fumes, lead, working with video display terminals (VDTs) and computer monitors. In addition, the questionnaire assessed the presence of other risk factors such as consanguinity, smoking and history of any maternal diseases during the pregnancy with the child. Results: The results revealed that the odds of having a child with congenital malformation was higher (P < 0.01) if the father was occupationally exposed to pesticides (OR: 3.42, 95% CI: 1.97-5.92), solvents (OR: 5.63, 95% CI: 2.77-11.42), or welding fumes (OR: 2.98, 0.99-8.54) during the periconceptional period. However, consanguinity (OR: 1.91, 95% CI: 1.25-2.92) was a risk factor of developing congenital malformations among offspring. Conclusion: Control of workplace exposures and adherence to threshold limit values of those hazards should be adopted to minimize the risk of developing congenital malformations among offspring.

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Section: Discussionsupporting

confidence: 77%

Paternal occupational exposures and the risk of congenital malformations — A case-control study

El-Helaly¹,

Abdel-Elah²,

Haussein³

et al. 2011

International Journal of Occupational Medicine and Environmental Health

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“…Women with a neural tube defect-affected baby were also more likely to report living in the proximity to cultivated fields than control women [17]. Another study among Mexican women reported that working in agriculture around the time of conception was associated with a greater risk of anencephaly in the offspring [22]. More recently, a positive association has been found between placental concentrations of different organochlorine observed in urban microregions, suggesting that pesticide exposure may play an important role in the geographical distribution of mortality from congenital malformations only in rural areas.…”

Section: Ijomeh 2014;27(3) 482mentioning

confidence: 96%

“…Maternal exposure to domestic pesticides during the 1st trimester of pregnancy was associated with transposition of the great arteries in the offspring, particularly for exposure to herbicides and rodenticides [24]. Several other epidemiological studies also reported associations between pesticide exposure and a variety of congenital anomalies, particularly in the offspring of agricultural workers, in infants born to women living in the proximity of pesticide application areas or in babies conceived in a particular season [3,[16][17][18]20,22,23,36]. In Brazil, one study found a greater risk of congenital defects in births to parents exposed to pesticides at work or due to proximity to an application area [20].…”

Section: Ijomeh 2014;27(3) 482mentioning

confidence: 97%

Pesticide consumption, central nervous system and cardiovascular congenital malformations in the South and Southeast region of Brazil

Cremonese¹,

Freire²,

Camargo³

et al. 2014

International Journal of Occupational Medicine and Environmental Health

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Objectives: To investigate the association between per capita pesticide consumption and infant mortality rates from CNS and CVS congenital malformations in microregions in the South and Southeast Region of Brazil. Material and Methods: An ecological study was conducted using data on pesticide expenditure in 1985 and 1996, and deaths caused by CNS and CVS malformations in infants under 1 year old in 1986-1990 and 1997-2001, respectively. Per capita pesticide consumption and infant mortality rates were calculated for each microregion. Microregions were grouped according to quintiles of pesticide consumption, taking the first quintile as reference. The association between pesticide consumption and infant mortality was examined by calculating Spearman correlation coefficients (r) and mortality rate ratios (RR), stratifying by gender and type of microregion (urban or rural). Results: Significant and positive correlations between per capita pesticide consumption and rates of mortality due to CNS and CVS defects were observed in rural but not urban microregions. In general, mortality RRs for the 2 types of malformations in rural microregions were significantly higher in each quintile of pesticide consumption compared to the lowest quintile in the 2 study periods, with elevations ranging between 10% and 30%. Likewise, mortality RRs in these microregions showed significant trends of increase across quintiles of pesticide consumption in both study periods. In urban areas, however, mortality RRs from both CNS and CVS malformations were weak and not statistically significant, and a trend of increase of mortality with increasing pesticide usage was not observed. Conclusions:The results show the relevance of pesticide exposure in rural areas with intense agricultural activity, suggesting that such prenatal exposures may be related with the occurrence of certain congenital defects.

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“…Men working in the agriculture sector are at more than tenfold increased risk of infertility in comparison to those in other occupations [80]. Exposure of the father to pesticides during the preconception period or prior can also increase the risk of having anencephalic child [81].…”

Section: Pesticides and Other Polychlorinated Hydrocarbonsmentioning

confidence: 99%

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Sharma¹

2017

Ann Clin Lab Res

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Infertility has become ominous problem. On an average, about 10% of all couples face difficulty in starting a family and this creates a feeling of great personal failure, particularly in India where religious and socio-economic traditions have made it almost imperative for everyone to have children. A significant association had been found between impaired semen quality including sperm count, motility and morphology. In this review, the various contributory etiological factors i.e., exposure to heavy metals, pesticides, industrial chemicals, endocrine factors, genetics causes and modern life style had been discussed which have a serious impact on male infertility. In this article we analyzed data from different sources and present evidences of the possible etiology and risk factors for male infertility. There is a need to emerge at the indiscriminate use and disposal of environmental chemicals. Especially pesticides and industrial chemicals as the chemicals enter the food chain, surface and ground water which had potential for exposure during the critical period of development further avoiding tobacco smoking, excessive alcoholism, excessive heat exposure to the testes can help in improving the semen quality.

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Maternal and paternal occupational exposure to agricultural work and the risk of anencephaly

Abstract: These results support the hypothesis of the effect of maternal exposure to agricultural work on anencephaly and suggest that exposure of the father to pesticides in the periconceptional period or prior to this can also increase the risk of having an anencephalic child.

Cited by 78 publications

References 46 publications

Paternal occupational exposures and the risk of congenital malformations — A case-control study

Paternal occupational exposures and the risk of congenital malformations — A case-control study

Pesticide consumption, central nervous system and cardiovascular congenital malformations in the South and Southeast region of Brazil

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

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