Maternal and umbilical cord procalcitonin, high-sensitivity C-reactive protein, and interleukin-6 levels in preeclamptic and normotensive patients: A cross-sectional study

Lumbreras-Marquez, Jesus; Barraza-Salas, Marcelo; Reyther, Roberto Arturo Castillo; Maza-Labastida, S de la; Hernandez-Rayon, Yessica I.; Farber, Michaela K.; Vazquez-Alaniz, Fernando

doi:10.1016/j.preghy.2020.04.009

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…In addition, through citation searches of these articles, we identified 10 additional relevant studies. Due to inadequate reporting of procalcitonin data in 10 studies, a total of 25 articles met the final criteria for inclusion in this systematic review and meta‐analysis 16–35 . Among these studies, four did not contribute to the meta‐analysis, leaving 21 independent studies for analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Due to inadequate reporting of procalcitonin data in 10 studies, a total of 25 articles met the final criteria for inclusion in this systematic review and meta-analysis. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Among these studies, four did not contribute to the meta-analysis, leaving 21 independent studies for analysis.…”

Section: Main Re Sultsmentioning

confidence: 99%

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Procalcitonin levels in pregnancy: A systematic review and meta‐analysis of observational studies

Prabhu

Wilkie

MacEachern

et al. 2023

Intl J Gynecology & Obste

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BackgroundThe utility of procalcitonin to identify obstetric sepsis is unknown.ObjectiveTo calculate the mean (range) procalcitonin in pregnancy among healthy women not in labor (group 1), healthy women in labor (group 2), and women with preterm prelabor rupture of membranes (PPROM) without clinical chorioamnionitis (group 3).Search StrategyNLM PubMed, Elsevier Embase, and Wiley Cochrane Central Register of Controlled Trials from inception to February 21, 2022.Selection CriteriaTen or more pregnant women with procalcitonin reported at more than 20 weeks of pregnancy, with information on labor, PPROM, and infection. Exclusions were major medical comorbidities.Data Collection and AnalysisEach abstract and full‐text review was independently reviewed by the same two authors. Quality was reviewed using the Newcastle‐Ottawa Scale. A meta‐analysis was performed using a random effects model.Main ResultsThe systematic review included 25 studies: 10 (40%) of good quality and 15 (60%) of poor quality. The meta‐analysis included 21 studies. Mean procalcitonin in group 1 was 0.092 ng/mL (range 0.036–0.049 ng/mL), in group 2 it was 0.130 ng/mL (range 0.049–0.259 ng/mL), and in group 3 it was 0.345 ng/mL (range 0.005–1.292 ng/mL).ConclusionsAmong healthy pregnant women not in labor, procalcitonin levels are comparable to those in non‐pregnant adults and may be useful in identifying infection. Procalcitonin levels in other groups overlap abnormal values of procalcitonin in non‐pregnant adults, and may not discriminate infection among women in labor or with obstetric comorbidities.ProsperoCRD42020157376, registered 4/28/2020.

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Section: Resultsmentioning

confidence: 99%

Section: Main Re Sultsmentioning

confidence: 99%

Procalcitonin levels in pregnancy: A systematic review and meta‐analysis of observational studies

Prabhu

Wilkie

MacEachern

et al. 2023

Intl J Gynecology & Obste

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“…A positive correlation was observed for both PCT and hs-CRP with MAP in maternal and umbilical venous samples. However, there was no correlation between IL-6 and MAP in maternal or umbilical venous samples [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of T-Regulatory Cells and Inflammatory Cytokines in Preeclampsia

Koppisetty,

Dash,

Saharia

et al. 2023

Cureus

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Background Preeclampsia (PE) is a prenatal hypertension condition with unknown aetiology which is one of the leading causes of maternal morbidity and mortality, premature delivery, and foetal and neonatal mortality. T-regulatory cells (T-regs) are the specific subsets of T-lymphocytes that play a key role in the mechanisms of maternal-foetal tolerance, contributing to an effective immunological role in protecting the allogenic foetus during pregnancy and preventing pregnancy-related complications. This study evaluated the T-regs in PE and correlated the T-regs with inflammatory markers in the pathophysiology and for early diagnosis of PE. Methods After clearance from Institutional Ethics Committee, the participants were recruited from the Department of Obstetrics and Gynaecology. Three study groups were included a) normal reproductive age group women b) normal pregnant women c) PE pregnant women. 5 ml of venous blood was collected from each participant. Biochemical and haematological parameters estimation was done in Hospital’s central laboratory. T-regs (CD4, CD25, FOXP3) were assessed using a flow-cytometer, and inflammatory markers (TGF-β1, IL-6, hsCRP) were assessed by ELISA and Beckman Coulter autoanalyzer in the Department of Biochemistry, AIIMS, Bhubaneswar. Results We found that the levels of CD4+CD25+ T-regs were lower in PE than in normal pregnancy, but this difference was not statistically significant (p = 0.349). The levels of CD4+FOXP3+ T-regs in PE were significantly lower compared to both normal pregnant women (p = 0.001) and normal non-pregnant women (p = 0.001). In comparison to women with PE, the levels of TGF-β1 were significantly higher in normal non-pregnant women (p = 0.020) and were higher, although not significantly so, in normal pregnant women (p = 0.994). The levels of IL-6 in women with PE were significantly higher than in normal pregnant women (p = 0.01) and normal non-pregnant women (p = 0.048). The levels of hsCRP in women with PE were significantly higher than in normal pregnant women (p = 0.045) and were higher, but not statistically significant, compared to normal non-pregnant women (p = 0.094). Conclusion The results of the study, showing a decrease in T-regs and an increase in inflammatory markers like TGF-β1, IL-6, and hsCRP levels in PE, have potential implications for the early diagnosis and management of the condition. Incorporating assessments of CD4+FOXP3+ T-regs and inflammatory markers into screening protocols, along with regular prenatal care and monitoring, can aid in the timely detection and implementation of appropriate management strategies. By intervening early, the risks associated with PE can be reduced, optimizing both maternal and fetal health.

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Efficacy of electroacupuncture combined with intravenous patient-controlled analgesia after cesarean delivery: a randomized clinical trial

Jin

et al. 2023

American Journal of Obstetrics & Gynecology MFM

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Maternal and umbilical cord procalcitonin, high-sensitivity C-reactive protein, and interleukin-6 levels in preeclamptic and normotensive patients: A cross-sectional study

Cited by 6 publications

References 27 publications

Procalcitonin levels in pregnancy: A systematic review and meta‐analysis of observational studies

Procalcitonin levels in pregnancy: A systematic review and meta‐analysis of observational studies

An Evaluation of T-Regulatory Cells and Inflammatory Cytokines in Preeclampsia

Efficacy of electroacupuncture combined with intravenous patient-controlled analgesia after cesarean delivery: a randomized clinical trial

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