Maternal Body Mass Index and the Risk of Preeclampsia: A Systematic Overview

O’Brien, Tara E.; Ray, Joel G.; Chan, Wee‐Shian

doi:10.1097/01.ede.0000059921.71494.d1

Cited by 656 publications

(407 citation statements)

References 40 publications

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“…Other studies also showed that overweight and obesity prior to and/or during pregnancy are associated with the occurrence of GH, PE and CH, and that the risk for PE doubles for every five to seven kg/m 2 increase in the body mass index as measured before pregnancy 19,27 . However, in some studies, obesity was not identified as an independent risk factor but was rather associated with race, showing that non-Hispanic white obese women had a higher risk for PE when compared to black, Asian and white Hispanic obese women 28,29 .…”

Section: Discussionmentioning

confidence: 94%

Estudo dos principais fatores de risco maternos nas síndromes hipertensivas da gestação

Assis¹,

Viana²,

Rassi³

2008

Arq. Bras. Cardiol.

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Section: Discussionmentioning

confidence: 94%

Estudo dos principais fatores de risco maternos nas síndromes hipertensivas da gestação

Assis¹,

Viana²,

Rassi³

2008

Arq. Bras. Cardiol.

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“…Matching for BMI was within 2 kg/m 2 and nulliparous or multiparous for parity. The rationale for the matching was that high and low maternal age, nulliparity, and high BMI are risk factors for PE [48][49][50][51][52][53][54][55][56].…”

Section: Methodsmentioning

confidence: 99%

The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age

Erez

Romero

Espinoza

et al. 2008

The Journal of Maternal-Fetal & Neonatal Medicine

273

233

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The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age, The Journal of Maternal-Fetal & Neonatal Medicine, 21:5, 279-287, DOI: 10.1080 AbstractIntroduction. An imbalance between angiogenic and anti-angiogenic factors has been proposed as central to the pathophysiology of preeclampsia (PE). Indeed, patients with PE and those delivering small-for-gestational age (SGA) neonates have higher plasma concentrations of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and the soluble form of endoglin (s-Eng), as well as lower plasma concentrations of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) than do patients with normal pregnancies. Of note, this imbalance has been observed before the clinical presentation of PE or the delivery of an SGA neonate. The objective of this study was to determine if changes in the profile of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters are associated with a high risk for the subsequent development of PE and/or delivery of an SGA neonate. Methods. This longitudinal case-control study included 402 singleton pregnancies in the following groups: (1) normal pregnancies with appropriate for gestational age (AGA) neonates (n ¼ 201); (2) patients who delivered an SGA neonate (n ¼ 145); and (3) patients who developed PE (n ¼ 56). Maternal plasma samples were obtained at the time of each prenatal visit, scheduled at 4-week intervals from the first or early second trimester until delivery. In this study, we included two samples per patient: (1) first sample obtained between 6 and 15 weeks of gestation ('first trimester' sample), and (2) second sample obtained between 20 and 25 weeks of gestation ('second trimester' sample). Plasma concentrations of s-Eng, sVEGFR-1, and PlGF were determined by specific and sensitive immunoassays. Changes in the maternal plasma concentrations of these angiogenesis-related factors were compared among normal patients and those destined to develop PE or deliver an SGA neonate while adjusting for maternal age, nulliparity, and body mass index. General linear models and polytomous logistic regression models were used to relate the analyte concentrations, ratios, and product to the subsequent development of PE and SGA. Results.(1) An increase in the maternal plasma concentration of s-Eng between the first and second trimesters conferred risk for the development of preterm PE and SGA (OR 14.9, 95% CI 4.9-45.0 and OR 2.9, 95% CI 1.5-5.6, respectively).(2) An increase in the maternal plasma concentration of sVEGFR-1 between the first and second trimester conferred risk for the development of preterm PE (OR 3.9, 95% CI 1.2-12.6). (3) A subnormal increase in maternal plasma PlGF concentration between the first and the second trimester was a risk factor for the subsequent development of preterm and term PE (OR 4....

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“…18,19 Hypertensive disease of pregnancy, including pre-eclamptic toxaemia (PET) occurs in obesity with a frequency two to four times that of mothers with healthy BMI. 20 The association between PET and raised BMI occurs independently of gestational diabetes, and demonstrates a linear rise in risk with increasing BMI, from a doubling of risk in overweight mothers to a fourfold increase in those categorized as grade III obesoty. 8,13 Mechanical complications associated with pregnancy such as pelvic pain and lower back pain are reported more frequently in overweight and obese women during pregnancy.…”

Section: Adverse Pregnancy Outcomementioning

confidence: 99%

The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome

Dennedy

Dunne

2010

Best Practice & Research Clinical Endocrinology & Metab

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Maternal Body Mass Index and the Risk of Preeclampsia: A Systematic Overview

Cited by 656 publications

References 40 publications

Estudo dos principais fatores de risco maternos nas síndromes hipertensivas da gestação

Estudo dos principais fatores de risco maternos nas síndromes hipertensivas da gestação

The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age

The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome

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