Maternal breast cancer risk in relation to birthweight and gestation of her offspring

Swerdlow, Anthony; Wright, Lauren B.; Schoemaker, Minouk J.; Jones, Michael E.

doi:10.1186/s13058-018-1035-6

Cited by 13 publications

(16 citation statements)

References 56 publications

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“…The present systematic review and meta-analysis suggested an increase in the BC risk (RR = 1.03) in women with a PB 26-31 gestational weeks compared to 40-41 gestational weeks. Similar to our study, Swerdlow et al [23] have shown in their study that the risk in women with gestational age of 26-31 weeks was 2.4 times compared to 40-41 weeks. Previous studies as well as the results of this study showed that early delivery may increase the risk of BC.…”

Section: Discussionsupporting

confidence: 92%

“…Previous studies as well as the results of this study showed that early delivery may increase the risk of BC. Swerdlow et al [23] have suggested that hormonal stimulation and breast proliferation at the beginning of pregnancy and the lack of enough opportunity for differentiation that occurs at the end of pregnancy are the cause of this relationship. Mammary cells in human and animals differentiate in the third trimester [28][29][30] and therefore a full term pregnancy is considered as a protective factor for BC [31].…”

Section: Discussionmentioning

confidence: 99%

“…Swerdlow et al [23] have shown in their study that gestational age is inversely associated with BC (especially before menopause), and the risk in women with gestational age of 26-31 weeks was 2.4 times compared to 40-41 weeks. However, M Kaijser et al [24] suggested that PB and low birth weight are not associated with an increased risk of BC.…”

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confidence: 89%

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Preterm Birth and Breast Cancer Risk: A Systematic Review and Meta-Analysis

Razavi¹,

Sepidarkish²,

Maleki‐Hajiagha³

et al. 2020

Preprint

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Background: The characteristics of pregnancy, such as gestational age are related to the level of maternal hormones, which levels of these hormones can be associated with breast cancer (BC) risk. Therefore, the aim of this study was to determine the relationship between the preterm birth (PB) and BC risk in women in a systematic review and meta-analysis.Methods: In this systematic review and meta-analysis, published studies were located back to the earliest available publication date (1983), using the Medline/PubMed, Embase, Scopus and Web of Science (Clarivate analytics) bibliographic databases. Eligibility, methodological quality, and data extraction were done by two independent reviewers, and finally, to calculate the pooled estimates, Meta-analysis was performed.Results: Thirteen studies including a total of 2,845,553 women were included in this meta-analysis. Pooled results suggested that PB could increase the risk of BC (RR= 1.03, 95% CI: 1.00, 1.07; I2= 62.5%). Risk was significantly increased in women with a PB at >37 gestational weeks (RR = 1.03, 95% CI: 1.01, 1.06) and 26-31 gestational weeks (RR = 1.03, 95% CI: 1.01, 1.06) compared to those with 40-41 gestational weeks. A significant increment in the risk of BC in uniparous women with a PB (RR = 1.05, 95% CI = 1.01, 1.08) and women with >45 years (RR = 1.12, 95% CI = 1.01, 1.24) was observed. Conclusions: The results of this study supported the higher risk of BC in all woman with PB, primiparous women and women with >45 years. Therefore, more care and screening for early detection of the disease is recommended in these women.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Preterm Birth and Breast Cancer Risk: A Systematic Review and Meta-Analysis

Razavi¹,

Sepidarkish²,

Maleki‐Hajiagha³

et al. 2020

Preprint

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“…Women with preterm delivery in anamnesis have also been shown to have an increased risk of subsequent ophthalmic complications, such as diabetic retinopathy and glaucoma [ 24 ], chronic kidney disease, end-stage kidney disease [ 25 ], and breast cancer [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

A History of Preterm Delivery Is Associated with Aberrant Postpartal MicroRNA Expression Profiles in Mothers with an Absence of Other Pregnancy-Related Complications

Hromadníková

Krofta

2021

IJMS

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This prospective cross-sectional case-control study investigated the postpartal gene expression of microRNAs associated with diabetes/cardiovascular/cerebrovascular diseases in the peripheral white blood cells of women with anamnesis of preterm pre-labor rupture of membranes (n = 58), spontaneous preterm birth (n = 55), and term delivery (n = 89) by a quantitative reverse transcription polymerase chain reaction. After pregnancies complicated by preterm pre-labor rupture of membranes or spontaneous preterm birth, mothers showed diverse expression profiles for 25 out of 29 tested microRNAs (miR-1-3p, miR-16-5p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-24-3p, miR-26a-5p, miR-29a-3p, miR-100-5p, miR-103a-3p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-181a-5p, miR-195-5p, miR-199a-5p, miR-221-3p, miR-499a-5p, and miR-574-3p). The earliest gestational ages at delivery and the lowest birth weights of newborns were associated with the highest postpartal levels of the previously mentioned microRNAs in maternal peripheral white blood cells. Administration of tocolytic drugs in order to prolong pregnancy, used in order to administer and complete a full course of antenatal corticosteroids, was associated with alterations in postpartal microRNA expression profiles to a lesser extent than in women with imminent delivery, where there was insufficient time for administration of tocolytics and antenatal corticosteroids. Overall, mothers who did not receive tocolytic therapy (miR-24-3p and miR-146a-5p) and mothers who did not receive corticosteroid therapy (miR-1-3p, miR-100-5p, and miR-143-3p) had increased or showed a trend toward increased postpartal microRNA expression when compared with mothers given tocolytic and corticosteroid therapy. In addition, mothers with serum C-reactive protein levels above 20 mg/L, who experienced preterm labour, showed a trend toward increased postpartal expression profiles of miR-143-3p and miR-199a-5p when compared with mothers with normal serum C-reactive protein levels. On the other hand, the occurrence of maternal leukocytosis, the presence of intra-amniotic inflammation (higher levels of interleukin 6 in the amniotic fluid), and the administration of antibiotics at the time of preterm delivery had no impact on postpartal microRNA expression profiles in mothers with a history of preterm delivery. Likewise, the condition of the newborns at the moment of birth, determined by Apgar scores at 5 and 10 min and the pH of cord arterial blood, had no influence on the postpartal expression profiles of mothers with a history of preterm delivery. These findings may contribute to explaining the increased cardiovascular risk in mothers with anamnesis of preterm delivery, and the greater increase of maternal cardiovascular risk with the decrease of gestational age at delivery. Women with preterm delivery in their anamnesis represent a high-risk group with special needs on a long-term basis, with a need to apply preventive and therapeutic interventions as early as possible.

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“…Among those, the association between birthweight and breast cancer has been attracted much research interest. Although a positive correlation between women's birthweight and breast cancer risk was discovered in some studies (11,12,20,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), some others failed to replicate such connection or even detected inconsistent correlations in effect direction (13,15,21,22,(33)(34)(35)(36)(37)(38)(39)(40)(41). These inconsistent ndings may be partly due to potential confounding in uences commonly arisen in observational studies, making it di cult to draw a de nitive conclusion on the causal association between birthweight and breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality

Zhang

Qiao

Zhang

et al. 2022

Preprint

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Background Previous studies demonstrated a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations also emerged, and the nature of such relationship remains unknown. Methods Using summary statistics of birthweight (n=264,498 for own birthweight and 179,360 for offspring birthweight) and breast cancer (n=266,081), we assessed the fetal/maternal-specific genetic correlation between them via LDSC and prioritized fetal/maternal-specific pleiotropic genes through MAIUP. Relying on summary statistics we conducted Mendelian randomization (MR) analyses to evaluate the fetal/maternal-specific origin of causal relationship between birthweight, age of menarche, age at menopause and breast cancer. Results With summary statistics we identified a positive genetic correlation between fetal-specific birthweight and breast cancer (rg=0.123 and P=0.013) as well as a negative but insignificant correlation between maternal-specific birthweight and breast cancer (rg=-0.068, P=0.206); and detected 84 pleiotropic genes shared by fetal-specific birthweight and breast cancer, 49 shared by maternal-specific birthweight and breast cancer. We also revealed fetal-specific birthweight indirectly influenced breast cancer risk in adulthood via the path of age of menarche or age at menopause in terms of MR-based mediation analysis. Conclusion This study reveals that shared genetic foundation and causal mediation commonly drive the connection between the two traits, and that fetal/maternal-specific birthweight plays substantially distinct roles in such relationship. However, our work offers little supportive evidence for the fetal origins hypothesis of breast cancer originating in utero.

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Maternal breast cancer risk in relation to birthweight and gestation of her offspring

Cited by 13 publications

References 56 publications

Preterm Birth and Breast Cancer Risk: A Systematic Review and Meta-Analysis

Preterm Birth and Breast Cancer Risk: A Systematic Review and Meta-Analysis

A History of Preterm Delivery Is Associated with Aberrant Postpartal MicroRNA Expression Profiles in Mothers with an Absence of Other Pregnancy-Related Complications

Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality

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