Maternal cadmium exposure and neurobehavior in children: The HOME study

Yang, Weili; Vuong, Ann M.; Xie, Changchun; Dietrich, Kim N.; Lanphear, Bruce P.; Braun, Joseph M.; Yolton, Kimberly; Chen, Aimin

doi:10.1016/j.envres.2020.109583

Cited by 18 publications

(12 citation statements)

References 32 publications

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“… Maternal blood Cd Median 4.24 μg/L, range 0.13- 4.55 μg/L Gesell Development Domains Lower development quotient in social domain of Gesell Dev. Schedule H [ 11 ] 4-5 years 302 Spain Cohort child gender, psychologist, child age at neuropsychological assessment, social class, maternal smoking during pregnancy, pre-pregnancy BMI Cd in placenta homogenates Median 4.1 ng/g McCarty Scale of Children's Abilities WASI No association M/H [ 41 ] at ages 5 and 8 years 276 USA Cohort maternal depression, maternal IQ, sociodemographic factor, exposure to tobacco, lead and ∑PCB Maternal urinary Cd Geometric mean 0.17 ± 2.29 μg/g creatinine Bayley Scale of Infant Development II, the Wechsler Preschool and Primary Scales of Intelligence III and IV No significant association M/H [ 42 ] school age 6-7 years 296 China Cohort sex, maternal age at delivery, maternal education level, family annual income, family inhabitation area and passive smoking cord blood and children's urine Geometric mean urinary Cd 0.18 ± 2.37 μg/L (specific gravity-adjusted); geometric mean cord blood Cd 0.36 ± 2.01 μg/L Wechsler Intelligence Scale for Children-Chinese Revised (WISC-CR) Cord blood Cd and urinary Cd was negatively associated with FSIQ but only in boys; in girls, only urinary Cd was negatively associated with IQ M/H [ 26 ] 2 years 3542 Japan cohort Pre-pregnancy BMI, diabetes, occupation, household income, education smoking, age at delivery, marital status, parity, Pb, Hg Maternal and cord blood Cd Maternal blood mean: 0.79 ± 0.39 μg/L; cord blood mean: 0.05 ± 0.02 μg/L Kyoto Scale of Psychological Development Maternal blood Cd associated with lower DQ in boys among smoking mothers and those with diabetes M/H …”

Section: Resultsmentioning

confidence: 99%

“…As cadmium has a relatively long half-life of excretion (11 years), maternal urinary cadmium concentrations are a good biomarker of prenatal exposures, along with maternal blood which represents more recent exposures. Four papers related the study outcomes to maternal urinary cadmium concentrations [ 10 , 17 , 18 , 41 ], while another four papers analysed cadmium in maternal blood [ 14 , 16 , 26 , 40 ]. Five studies used childrens’ urinary cadmium as the exposure marker ([ 13 , 25 , 29 , 33 , 42 ]), four analysed cord blood cadmium levels [ 23 , 26 , 29 , 42 ] and a single study recorded cadmium in placental or cord blood [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

“…One study did not give information on loss to follow-up and was therefore downgraded to "Adequate (A)" [ 11 ]. We evaluated studies with either low participation rates or significant loss to follow-up as "Deficient (D)" in the participant selection domain [ 14 , 18 , 23 , 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

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Cadmium exposures and deteriorations of cognitive abilities: estimation of a reference dose for mixture risk assessments based on a systematic review and confidence rating

Chatterjee

Kortenkamp

2022

Environ Health

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To support a mixture risk assessment with a focus on developmental neurotoxicity we evaluated the strength of evidence for associations of cadmium exposures with declines in IQ by conducting a systematic review and confidence rating. We searched peer-reviewed studies published in English between 2012 and July 2021 and identified 15 eligible studies (11 prospective cohort studies, and 4 cross-sectional studies). Of the 10 studies that observed associations of cadmium exposure with child IQ declines, two achieved an overall “High (H)” confidence rating, five a “Medium to High (M/H)”, one a “Medium (M)” and two a “Low (L)” confidence rating. Five studies did not detect significant associations between cadmium exposure and reduced cognitive ability; of these, two received a “High (H)” confidence rating, two an overall rating of “Medium to High (M/H)” and one a “Medium (M)” rating. The null findings reported by the “High (H)” and Medium to High (M/H)” studies could partly be explained by low exposures to cadmium or confounding with high levels of lead. By using a one-compartment toxicokinetic model in a reverse dosimetry approach, we estimated that a daily intake of 0.2 μg/kg body weight/day corresponds to urinary cadmium levels no longer associated with cognitive declines observed in a “High (H)”-confidence study. This estimate is 1.8-fold lower than the current health-based guidance value (HBGV) for kidney toxicity of 0.36 μg/kg bodyweight/day established by the European Food Safety Authority (EFSA). Our value does not have the normative character associated with health-based guidance values and is intended only as a reasonable estimate for the purpose of mixture risk assessments. However, with cadmium exposures in Europe between 0.28 (middle bound) and up to 0.52 μg/kg bodyweight/day (95th percentile), our review suggests that pregnant women and children are poorly protected against neurodevelopmental effects. This warrants a revision of the current HBGV.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Cadmium exposures and deteriorations of cognitive abilities: estimation of a reference dose for mixture risk assessments based on a systematic review and confidence rating

Chatterjee

Kortenkamp

2022

Environ Health

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“…In recent years, the hazardous nonessential metal Cd has been considered an endocrine disruptor [ 22 ], by the attributed association with obesity, diabetes, and carcinogenesis. In addition to Cd-induced acute or chronic target organ damage, early-life Cd exposure-related health risks have received more attention [ 23 – 25 ]. Jackson et al showed that gestational Cd exposure induced preneoplastic lesions in the liver of female mice in early adulthood (about 3 months old) [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Early‐Life Exposure to Low‐Dose Cadmium Accelerates Diethylnitrosamine and Diet‐Induced Liver Cancer

Men

Young

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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Maternal exposure to cadmium causes obesity and metabolic changes in the offspring, including nonalcoholic fatty liver disease-like pathology. However, whether maternal cadmium exposure accelerates liver cancer in the offspring is unknown. This study investigated the impact of early-life exposure to cadmium on the incidence and potential mechanisms of hepatocellular carcinoma (HCC) in offspring subjected to postweaning HCC induction. HCC in C57BL/6J mice was induced by diethylnitrosamine (DEN) injection at weaning, followed by a long-term high-fat choline-deficient (HFCD) diet. Before weaning, liver cadmium levels were significantly higher in mice with early-life cadmium exposure than in those without cadmium exposure. However, by 26 and 29 weeks of age, hepatic cadmium fell to control levels, while a significant decrease was observed in copper and iron in the liver. Both male and female cadmium-exposed mice showed increased body weight compared to non-cadmium-treated mice. For females, early-life cadmium exposure also worsened insulin intolerance but did not significantly promote DEN/HFCD diet-induced liver tumors. In contrast, in male mice, early-life cadmium exposure enhanced liver cancer induction by DEN/HFCD with high incidence and larger liver tumors. The liver peritumor tissue of early-life cadmium-exposed mice exhibited greater inflammation and disruption of fatty acid metabolism, accompanied by higher malondialdehyde and lower esterified triglyceride levels compared to mice without cadmium exposure. These findings suggest that early-life exposure to low-dose cadmium accelerates liver cancer development induced by a DEN/HFCD in male mice, probably due to chronic lipotoxicity and inflammation caused by increased uptake but decreased consumption of fatty acids.

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“…Furthermore, from a longitudinal study, it was found that the rate of decline in IQ at 3 and 5 years of age was steeper at lower than at higher concentrations of postnatal lead exposures [ 3 ]. While prenatal cadmium exposures have not been shown to be significantly associated with children’s cognitive performance at ages 1–8 years in prospective pregnancy and birth cohorts, negative effects on cognitive function are suggested in animal models [ 4 , 10 ]. Prenatal methylmercury exposures result in declining language, attention, and memory abilities at age 7 years, and declining IQ was observed at age 22 years [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Associations between Metal Exposures and Cognitive Function in American Older Adults

Sasaki

Carpenter

2022

IJERPH

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Cognitive function frequently declines with older age, independently of the development of neurodegenerative diseases, and few interventions are known to counter this decline. Exposure to neurotoxic metals may contribute to this decline in cognitive function in older adults. Using the National Health and Nutrition Examination Survey (NHANES) data, the performance of 3042 adults aged 60 years and older on three cognitive tests for immediate, delayed, and working memory were examined in relation to blood concentrations of seven metals and metalloids and urinary concentrations of nineteen metals and metabolites. Using linear regression models, associations between cognitive tests and logarithms of metal exposures were adjusted for age, sex, ethnicity, education level, depression, diabetes, alcohol consumption, and cigarette use. Increased selenium was strongly associated with better performance on all three cognitive tests. Cadmium and lead were negatively associated with performance on all three cognitive tests. Some urinary metabolites of arsenic, urinary lead, cadmium, and tungsten were significantly associated with poor performance on some tests. In older adults, higher selenium levels were strongly associated with better cognitive performance.

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Maternal cadmium exposure and neurobehavior in children: The HOME study

Cited by 18 publications

References 32 publications

Cadmium exposures and deteriorations of cognitive abilities: estimation of a reference dose for mixture risk assessments based on a systematic review and confidence rating

Cadmium exposures and deteriorations of cognitive abilities: estimation of a reference dose for mixture risk assessments based on a systematic review and confidence rating

Early‐Life Exposure to Low‐Dose Cadmium Accelerates Diethylnitrosamine and Diet‐Induced Liver Cancer

Associations between Metal Exposures and Cognitive Function in American Older Adults

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