Maternal Caffeine Intake during Pregnancy and Risk of Fetal Growth Restriction: A Large Prospective Observational Study

Boylan, Sinéad; Gott, David Michael; Thatcher, Natalie J; Creton, S.; Tahourdin, C.; Gibson, Gillian; Greenwood, DC; Taub, Nicholas; Gay, Catherine; Potdar, Neelam; Konje, Justin C.; Simpson, Nigel; Walker, JJ; Dolby, Vivien A.; Ong, H.-C.; Kassam, S.; Chipps, Karen C.; Boyland, S.; Kirk, S.; Cade, Janet; White, Kay; Shires, Susan; Hay, Alastair; Wild, C.; Cooke, Marcus S.; Thomas, James; Hill, E. P.; Charvill, J.; Ghandi, C.

doi:10.1097/01.aoa.0000358406.25166.32

Cited by 6 publications

(15 citation statements)

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“…This was included in the low birth weight analysis as these formed the majority of events, but with sensitivity analysis to confirm that this did not substantially change the results. One study provided additional information on miscarriage and stillbirth separately that was incorporated into the meta-analyses [29]. One publication provided results for the association between preterm delivery and caffeine separately for small for gestational age infants and normal for gestational age infants [18].…”

Section: Literature Searchmentioning

confidence: 99%

Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose–response meta-analysis

et al. 2014

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Section: Literature Searchmentioning

confidence: 99%

Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose–response meta-analysis

et al. 2014

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“…Detailed methods on the caffeine assessment are described elsewhere [11]. A validated caffeine assessment tool (CAT) to record habitual caffeine intake was administered at booking (8-12 weeks) by a clinical research fellow or research midwives, and completed 6 by the participants during weeks 13-28, and finally weeks 28 to the end of pregnancy.…”

Section: Caffeine Intakementioning

confidence: 99%

“…Caffeine, in particular, has received much interest in recent years. Studies have shown that maternal caffeine consumption may increase the risk of adverse pregnancy outcomes [11][12][13][14][15]. It has been suggested that women who experience nausea may be less likely to consume caffeine [16].…”

Section: Introductionmentioning

confidence: 99%

“…The Caffeine and Reproductive Health (CARE) study [11] addressed the methodological issues described above through a prospective, longitudinal observational study of the relationship between maternal caffeine intake, metabolism and fetal growth restriction. The results of this study showed that maternal caffeine consumption throughout pregnancy was associated with an increased risk of fetal growth restriction and that this association was stronger among women with a faster caffeine metabolism than those with a slower caffeine metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…Hence our aim here was to use the valuable data collected by the CARE study [11] to explore the relationships between nausea and vomiting of pregnancy and (a): fetal growth restriction; and (b) maternal caffeine metabolism and fetal growth restriction.…”

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Does Nausea and Vomiting of Pregnancy Play a Role in the Association Found Between Maternal Caffeine Intake and Fetal Growth Restriction?

Boylan

Greenwood

Alwan

et al. 2012

Matern Child Health J

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ObjectivesThe aim of this study was to explore the relationships between nausea and vomiting in pregnancy and (a): fetal growth restriction; and (b) maternal caffeine metabolism and fetal growth restriction. MethodsA cohort of 2643 pregnant women, aged 18-45 years, attending two UK maternity units between 8-12 weeks gestation, was recruited. A validated tool assessed caffeine intake at different stages of pregnancy and caffeine metabolism was assessed from a caffeine challenge test. Experience of nausea and vomiting of pregnancy was self-reported for each trimester. Adjustment was made for confounders, including salivary cotinine as a biomarker of current smoking status. ResultsThere were no significant associations between fetal growth restriction and nausea and vomiting in pregnancy, even after adjustment for smoking and alcohol intake. There were no significant differences in the relationship between caffeine intake and fetal growth restriction between those experiencing symptoms of nausea and vomiting and those who did not, for either the first (p=0.50) or second trimester (p=0.61) after adjustment for smoking, alcohol intake and caffeine half-life. There were also no significant differences in the relationship between caffeine half-life and fetal growth restriction between those experiencing symptoms of nausea and vomiting and those who 2 did not, for either the first trimester (p=0.91) or the second trimester (p=0.45) after adjusting for smoking, alcohol intake and caffeine intake. ConclusionThe results from this study show no evidence that the relationship between maternal caffeine intake and fetal growth restriction is modified by nausea and vomiting in pregnancy.

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Caffeine intake during pregnancy, late miscarriage and stillbirth

et al. 2010

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Caffeine is a commonly consumed drug during pregnancy with the potential to affect the developing fetus. Findings from previous studies have shown inconsistent results. We recruited a cohort of 2643 pregnant women, aged 18-45 years, attending two UK maternity units between 8-12 weeks gestation from September 2003 to June 2006. We used a validated tool to assess caffeine intake at different stages of pregnancy and related this to late miscarriage and stillbirth, adjusting for confounders, including salivary cotinine as a biomarker of smoking status. There was a strong association between caffeine intake in the first trimester and subsequent late miscarriage and stillbirth, adjusting for confounders. Women whose pregnancies resulted in late miscarriage or stillbirth had higher caffeine intakes (geometric mean = 145 mg/day; 95% CI: 85 to 249) than those with live births (103 mg/day; 95% CI: 98 to 108). Compared to those consuming <100 mg/day, odds ratios increased to 2.2 (95% CI: 0.7 to 7.1) for 100-199 mg/day, 1.7 (0.4 to 7.1) for 200-299 mg/day, and 5.1 (1.6 to 16.4) for 300+ mg/day (P trend =0.004). Greater caffeine intake is associated with increases in late miscarriage and stillbirth. Despite remaining uncertainty in the strength of association, our study strengthens the observational evidence base on which current guidance is founded.

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Maternal Caffeine Intake during Pregnancy and Risk of Fetal Growth Restriction: A Large Prospective Observational Study

Abstract: This is a repository copy of Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study..

Cited by 6 publications

References 23 publications

Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose–response meta-analysis

Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose–response meta-analysis

Does Nausea and Vomiting of Pregnancy Play a Role in the Association Found Between Maternal Caffeine Intake and Fetal Growth Restriction?

Caffeine intake during pregnancy, late miscarriage and stillbirth

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