Maternal cardiovascular response to caffeine infusion in the pregnant ewe

Conover, Wayne B.; Key, Thomas C.; Resnik, Robert

doi:10.1016/0002-9378(83)91191-2

Cited by 4 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, our finding that maternal caffeine administration showed no effect on fetal systemic oxygenation is consistent with a previous study in sheep that found that maternal infusion of caffeine (8 mg/kg) was not associated with a significant alteration in uterine blood flow or fetal systemic oxygenation. 22 The hydrophobic properties of caffeine allow its rapid passage through all biological membranes, including the blood-brain and placental barriers. 4,5 In adult humans, caffeine is absorbed rapidly and completely from the gastrointestinal tract, and maximum caffeine concentration is attained within 15 to 60 minutes following oral ingestion, equaling 8 to 10 mg/L -1 for doses of 5 to 8 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

“…In the near-term pregnant ewe, the half-life of caffeine equals 3 to 7 hours, which is much shorter than in a near-term pregnant woman. 22,24 Adenosine has also been shown to modulate fetal behavior and the sleep-awake cycle, 26 which may be important for brain development and maturation. 27 In fact, the fetuses of mothers with high caffeine intake (>500 mg/d) have been shown to spend significantly more time in a state of arousal 28 and breathing movements.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Caffeine Administration and Cerebral Oxygenation in Near-Term Fetal Sheep

et al. 2007

View full text Add to dashboard Cite

The authors test the null hypothesis that maternal caffeine administration will not significantly alter fetal cerebral oxygenation. The authors measured fetal arterial blood gases, cortical tissue O(2) tension (tPO(2)), sagittal sinus blood gases, and laser Doppler cerebral blood flow in response to a 30-minute caffeine infusion (400 mg intravenously) into 7 near-term pregnant ewes, and they calculated fractional O(2) extraction and relative cerebral metabolic rate for O(2) (CMRO(2)). Following maternal caffeine infusion, both fetal cortical tPO(2) and sagittal sinus (HbO(2)) decreased significantly, from 10.7 +/- 0.9 to 6.8 +/- 1.1 Torr and from 46% +/- 2% to 37% +/- 6%, respectively. This was associated with significant 20% to 30% increases in fractional O(2) extraction and CMRO( 2). Fetal arterial blood gas values did not change significantly. In conclusion, maternal caffeine administration significantly decreases cerebral oxygenation without affecting systemic oxygenation in fetal sheep. The authors speculate that for a fetus that may be otherwise compromised, this increase in CMRO(2) with decreased cortical tPO(2) could present a problem.

show abstract

Section: Discussionmentioning

confidence: 99%