Maternal carriage of extended-spectrum beta-lactamase-producingEscherichia coliisolates in Argentina

Abstract

The aim of this study was to determine the prevalence of vaginal Escherichia coli colonization and perianal carriage of Enterobacteriaceae resistant to third generation cephalosporins in pregnant women. Vaginal and perianal samples from 259 pregnant women were studied. Vaginal swabs were inoculated onto MacConkey agar plates and perianal swabs were inoculated onto CHROMagar extended-spectrum beta-lactamase (ESBL) plates. The minimal inhibitory concentration of the isolates was determined using the Epsilometer test method. The phenotypic detection of ESBLs was performed by the combined disc method using cefotaxime versus cefotaxime plus clavulanate. The prevalence of vaginal E. coli colonization during pregnancy was 14.3%. The resistance rate to ampicillin, gentamicin, and cefotaxime was 48.6, 10.8, and 0.8%, respectively. Enterobacteriaceae resistant to third generation cephalosporins were recovered in 7.3% of all perianal specimens. Among them, 5.4% of pregnant women were colonized with E. coli ESBL-producer strains. The present study revealed that colonization with Enterobacteriaceae resistant to third generation cephalosporins is significant in pregnancy. ESBL-producing E. coli were the most prevalent organisms. Screening strategies designed to monitor for ESBL-producing E. coli could be useful in endemic areas to prevent perinatal transmission and the introduction of multiresistant strains to the maternity ward.

Antibiotic resistance properties of uropathogenic <i>Escherichia coli</i> isolated from pregnant women with history of recurrent urinary tract infections

“…Prevalence of antibiotic resistance in the E. coli strains isolated from pregnant women of Tanzania against ampicillin, sulfamethazoletrimethoprim, tetracycline, nitrofurantoin, ceftriaxone, gentamycin, ciprofloxacin and imipenem were 52.9, 64.7, 58.8, 5.9, 29.4, 5.9, 11.8 and 0 %, respectively [25]. Similar results have been reported from Nigeria [25], Iraq [27] and Argentina [28].…”

Extended-spectrum β-lactamase-producing Enterobacteriaceae among pregnant women in Norway: prevalence and maternal–neonatal transmission

“…[20][21][22][23] Reported carriage rates of ESBL-E in pregnant women range from 7.3 to 15.4%, and are likely to reflect carriage rates in the general healthy population in different regions. 6,[24][25][26] African or Asian origin was a risk factor for being colonized by ESBL-E, possibly due to higher carriage rates in these geographical areas. This is in concordance with a UK study analyzing stool samples from out-patients, where they found a statistically significant difference between carriage in the European (8.1%) and the Middle East/South Asian group (22.8%).…”

Perinatal vertical transmission of antibiotic‐resistant bacteria: a systematic review and proposed research strategy

“…The reported prevalence of E. coli vaginal colonisation in pregnant women ranges from 7% to 20% . One study from Argentina reported peri‐anal colonisation with ESBL‐producing E. coli in 5.4% of pregnant women . As part of an Olympics surveillance project (in collaboration with Public Health England) we have isolated ESBL‐producing Enterobacteriaceae from 20% of women of childbearing age (15–45 years) in north‐east London who submitted stool samples for laboratory examination .…”