Maternal coffee drinking in pregnancy and risk of small for gestational age birth

Parazzini, Fabio; Chiaffarino, Francesça; Chatenoud, Liliane; Tozzi, Luca; Cipriani, Sonia; Chiantera, Vito; Fedele, Luigi

doi:10.1038/sj.ejcn.1602052

Cited by 20 publications

(14 citation statements)

References 17 publications

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“…This was a case–control study on risk factors for SGA birth 10–11 . The cases were Italian women who delivered SGA babies at the Clinica Luigi Mangiagalli (the largest obstetric hospital in Milan) and the Obstetric and Gynaecology Clinic of the University of Verona.…”

Section: Methodsmentioning

confidence: 99%

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Induced abortion and risk of small‐for‐gestational‐age birth

Parazzini¹,

Cipriani

Chiaffarino³

et al. 2007

BJOG

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Objective To investigate the possibility of an association between previous induced abortion and subsequent birth of a small-forgestational-age (SGA) infant.Design Case-control study.Setting General and university hospitals.Methods Cases were 555 women who delivered SGA babies. Controls were 1966 women who gave birth at term (>37 weeks of gestation) to healthy infants of normal weight on randomly selected days at the hospital where cases had been identified. All women in the case and control categories were interviewed on the obstetric wards by one of a team of six interviewers. During the interviews, information was obtained regarding general sociodemographic factors, personal characteristics and habits, gynaecological and obstetric history, general anamnesis, family history of obstetric and gynaecological diseases, and the age of the father of the child. Further information on current pregnancy and delivery was also collected. We used conditional multiple logistic regression (with age as the matching variable), with maximum likelihood fitting, to obtain odds ratios and their corresponding 95% CIs. Included in the regression equations were terms for education, plus terms significantly associated in this data set with the risk of SGA birth (smoking in pregnancy, history of SGA, gestational hypertension and parity).Population Women admitted to a general and a university hospital.Results No significant increase in the risk of SGA birth was observed in women with a previous induced abortion [odds ratio (OR) 1.0; 95% CI 0.6-1.7]. The OR for SGA birth was 1.2 (95% CI 0.7-2.1) for preterm and 1.0 (95% CI 0.7-1.4) for term SGA births.Conclusion This study found no association between risk of SGA birth and induced abortion.

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Section: Methodsmentioning

confidence: 99%

“…The analysis therefore consisted of 25 factors identified as being of interest; dietary factors were not analysed. Parts of the analysis have previously been published 10–11 …”

Section: Methodsmentioning

confidence: 99%

Induced abortion and risk of small‐for‐gestational‐age birth

Parazzini¹,

Cipriani

Chiaffarino³

et al. 2007

BJOG

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“…During the years from 2000 to 2010, 17 articles were published evaluating the risk of maternal caffeine exposure and fetal weight reduction (Grosso et al, 2006, 2006; Clausson et al, 2002; Klebanoff et al, 2002; Balat et al, 2003; Bracken et al, 2003; Ørskou et al, 2003; Vik et al, 2003; Parazzini et al, 2005; Santos et al, 2005; Tsubouchi et al, 2006; Bech et al, 2007; Diego et al, 2007; Infante‐Rivard, 2007; Care Study Group, 2008; Xue et al, 2008; Bakker et al, 2010).…”

Section: Epidemiology Studiesmentioning

confidence: 99%

“…Parazzini et al (2005) selected 555 women delivering singleton, small for gestational age (SGA <10th percentile) babies and 1,966 controls who delivered healthy, term singletons for a case–control study. Caffeine consumption was listed as the number of cups per day before pregnancy and during each trimester.…”

Section: Epidemiology Studiesmentioning

confidence: 99%

Evaluation of the reproductive and developmental risks of caffeine

Brent

Christian

Diener

2011

Birth Defects Research Pt B

120

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A risk analysis of in utero caffeine exposure is presented utilizing epidemiological studies and animal studies dealing with congenital malformation, pregnancy loss, and weight reduction. These effects are of interest to teratologists, because animal studies are useful in their evaluation. Many of the epidemiology studies did not evaluate the impact of the “pregnancy signal,” which identifies healthy pregnancies and permits investigators to identify subjects with low pregnancy risks. The spontaneous abortion epidemiology studies were inconsistent and the majority did not consider the confounding introduced by not considering the pregnancy signal. The animal studies do not support the concept that caffeine is an abortafacient for the wide range of human caffeine exposures. Almost all the congenital malformation epidemiology studies were negative. Animal pharmacokinetic studies indicate that the teratogenic plasma level of caffeine has to reach or exceed 60 µg/ml, which is not attainable from ingesting large amounts of caffeine in foods and beverages. No epidemiological study described the “caffeine teratogenic syndrome.” Six of the 17 recent epidemiology studies dealing with the risk of caffeine and fetal weight reduction were negative. Seven of the positive studies had growth reductions that were clinically insignificant and none of the studies cited the animal literature. Analysis of caffeine's reproductive toxicity considers reproducibility and plausibility of clinical, epidemiological, and animal data. Moderate or even high amounts of beverages and foods containing caffeine do not increase the risks of congenital malformations, miscarriage or growth retardation. Pharmacokinetic studies markedly improve the ability to perform the risk analyses. Birth Defects Res (Part B) 92:152–187, 2011. © 2011 Wiley-Liss, Inc.

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“…Excessive use of caffeine-containing analgesics has been linked to analgesic nephropathy (De Broe et al, 2003). Caffeine may also be harmful in pregnancy; intakes above 300 mg/day may be associated with low birth weight and miscarriage (Food Standards Agency, 2001;Parazzini et al, 2005). The UK Food Standards Agency has recommended that pregnant women should limit their intake to less than this amount, which is equivalent to four average-sized cups or three average-sized mugs of instant coffee or six average-sized cups of tea (Food Standards Agency, 2001).…”

Section: Adverse Effectsmentioning

confidence: 99%

Neuropsychiatric effects of caffeine

Winston¹,

Hardwick²,

Jaberi³

2005

Adv. psychiatr. treat

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Psychiatrists rarely enquire about caffeine intake when assessing patients. This may lead to a failure to identify caffeine-related problems and offer appropriate interventions. Excessive caffeine ingestion leads to symptoms that overlap with those of many psychiatric disorders. Caffeine is implicated in the exacerbation of anxiety and sleep disorders, and people with eating disorders often misuse it. It antagonises adenosine receptors, which may potentiate dopaminergic activity and exacerbate psychosis. In psychiatric in-patients, caffeine has been found to increase anxiety, hostility and psychotic symptoms. Assessment of caffeine intake should form part of routine psychiatric assessment and should be carried out before prescribing hypnotics. Gradual reduction in intake or gradual substitution with caffeine-free alternatives is probably preferable to abrupt cessation. Decaffeinated beverages should be provided on psychiatric wards.

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Maternal coffee drinking in pregnancy and risk of small for gestational age birth

Cited by 20 publications

References 17 publications

Induced abortion and risk of small‐for‐gestational‐age birth

Induced abortion and risk of small‐for‐gestational‐age birth

Evaluation of the reproductive and developmental risks of caffeine

Neuropsychiatric effects of caffeine

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