Maternal country of birth and previous pregnancies are associated with breast milk characteristics

Amoudruz, Petra; Holmlund, Ulrika; Schollin, Jens; Sverremark-Ekström, Eva; Montgomery, Scott

doi:10.1111/j.1399-3038.2008.00754.x

Cited by 31 publications

(40 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also observed variation in EGF as a negative function of infant age ( Figure 4B), a result that agrees well with earlier studies (Donovan and Odle 1994). Perhaps importantly, we observed relatively elevated levels of TGF-β 2 in the milk of Aeta women, suggesting a greater exposure to infectious pathogens (Amoudruz et al 2009;Peroni et al 2010); however, median levels in Aeta and Ilocano milks (2,419 and 1,644 pg/ml, respectively) were lower than mean values from Mali (3,727 pg/ml) and Sweden (3,703 pg/ml) (Holmlund et al 2010). Such a difference highlights the potential for global variation in the baseline values of some cytokines (McDade et al 2009).…”

Section: Discussionsupporting

confidence: 80%

“…Recent studies suggest that maternal history of exposure to microbial pathogens can elevate TGF-β concentrations in milk (Peroni et al 2010). For example, women who emigrated from developing countries to Sweden produced milk with significantly higher levels of TGF-β than did women born in Sweden (Amoudruz et al 2009), suggesting that early-life environments could play a more important role than adult environment in determining the level of TGF-β in breast milk.…”

Section: Adiponectinmentioning

confidence: 99%

See 1 more Smart Citation

Mount Pinatubo, Inflammatory Cytokines, and the Immunological Ecology of Aeta Hunter-Gatherers

Bernstein

Dominy

2013

Human Biology

View full text Add to dashboard Cite

Early growth cessation and reproduction are predicted to maximize fitness under conditions of high adult mortality, factors that could explain the pygmy phenotype of many rainforest hunter-gatherers. This lifehistory hypothesis is elegant but contentious in part because it lacks a clear biological mechanism. One mechanism stems from the field of human immunological ecology and the concept of inflammation "memory" across the life cycle and into subsequent generations. Maternal exposures to disease can infl uence immunological cues present in breast milk; because maternal provisioning via lactation occurs during critical periods of development, it is plausible that these cues can also mediate early growth cessation and small body size. Such epigenetic hypotheses are difficult to test, but the concept of developmental programming is attractive because it could explain how the stature of a population can change over time, in terms of both secular increases and rapid intergenerational decreases. Here we explore this concept by focusing on the Aeta, a population of former hunter-gatherers, and the Ilocano, a population of rice farmers. We predicted that Aeta mothers would produce breast milk with higher concentrations of four bioactive factors due to high infectious burdens. Further, we predicted that the concentrations of these factors would be highest in the cohort of women born in the early 1990s, when exposure to infectious disease was acute following the eruption of Mount Pinatubo in June 1991. We analyzed levels of adiponectin, C-reactive protein, and epidermal growth factor in the milk of 24 Aeta and 31 Ilocano women and found no detectable differences, whereas levels of transforming growth factor-β 2 were elevated among the Aeta, particularly as a function of maternal age. We found no difference between cohorts divided by the volcanic eruption (n = 43 born before, n = 12 born after). We discuss the implications of our findings for the terminal investment hypothesis and we suggest that the historical ecology of the Aeta is a promising model system for testing epigenetic hypotheses focused on the evolution of small body size. Abstract Early growth cessation and reproduction are predicted to maximize fitness under conditions of high adult mortality, factors that could explain the pygmy phenotype of many rainforest hunter-gatherers. This life-history hypothesis is elegant but contentious in part because it lacks a clear biological mechanism. One mechanism stems from the field of human immunological ecology and the concept of inflammation "memory" across the life cycle and into subsequent generations. Maternal exposures to disease can infl uence immunological cues present in breast milk; because maternal provisioning via lactation occurs during critical periods of development, it is plausible that these cues can also mediate early growth cessation and small body size. Such epigenetic hypotheses are difficult to test, but the concept of developmental programming is attractive because it could explain how the...

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Adiponectinmentioning

confidence: 99%

Mount Pinatubo, Inflammatory Cytokines, and the Immunological Ecology of Aeta Hunter-Gatherers

Bernstein

Dominy

2013

Human Biology

View full text Add to dashboard Cite

show abstract

“…While this was not measured directly, we adjusted for parity as a reliable indicator of number of older siblings. Also, it has been hypothesised that previous pregnancies—directly measured by parity—may influence immune-mediated disease risk through changes in the mother's immune profile 16. The measure of maternal smoking was incomplete as it was not always included in the Medical Birth Register.…”

Section: Discussionmentioning

confidence: 99%

Respiratory infections in preterm infants and subsequent asthma: a cohort study

et al. 2013

View full text Add to dashboard Cite

ObjectivesTo investigate whether gestational age modifies the association of airway infections that result in hospital admission during the first year after birth, with subsequent asthma risk after age 5 years.SettingHospital inpatients and a general population comparison group in Sweden followed for subsequent diagnoses in primary and secondary care.ParticipantsNational registers identified 42 334 children admitted to hospital for respiratory infection in their first year after birth during 1981–1995, individually matched with 211 594 children not admitted to hospital for infection during their first year.Primary outcomeAsthma diagnoses and prescribed asthma treatments after the age of 5 years identified through registers.ResultsCox regression was used to identify a HR (and 95% CI) of 1.51 (1.47 to 1.51) for the association of respiratory infection before 1 year of age with asthma after age 5 years, after adjustment for sex, gestational age, chronic lung disease, maternal asthma and maternal smoking. When stratified by gestational age (and with additional adjustment for birth weight), there is statistically significant effect modification by gestational age, with the highest magnitude asthma risk among those born with a gestational age of less than 28 weeks, producing an adjusted HR of 2.22 (1.59 to 3.09). This higher magnitude asthma risk persisted until after age 10 years, but differences in risk by gestational age were less pronounced for asthma after age 16 years.ConclusionsExtremely preterm infants are most likely to have chronic respiratory sequelae following respiratory infections in early life.

show abstract

“…All rights reserved. (36) Neutrophils (36) Dendritic cells (36) B2M, HLA-DRB5, C4A, CFB, ANPEP, CTSS, ERAP1 (35) MFGM (61,63) Exosomes (67) Bacteria and their components (143)(144)(145) Antibodies IgA (69, 72, 73, 75-77, 127, 146) IgG (69,146) IgM (69,76,146) Antigens β -lactoglobulin (73) Ovalbumin (73) Cytokines IL-1 (35,120) IL-2 (35,79,124,147) IL-3 (35) IL-4 (30, 35, 50, 68, 80-82, 124, 125, 147) IL-5 (35,50,68,80) IL-6 (31,35,50,68,80,122,124,131) IL-7 (35) IL-8 (31,35,68,122,147) IL-10 (30, 35, 50, 68, 73, 75, 80-83, 122, 124, 125, 131, 137, 147-149) IL-12 (35,83) IL-13 (30,…”

Section: Accepted Articlementioning

confidence: 98%

“…TGF-β1 (30, 31, 35, 50, 68, 72, 75-77, 80, 81, 83, 122, 127, 131, 137, 148, 149, 152, 153) TGF-β2 (30,31,35,50,52,68,72,73,75,77,80,122,125,127,152) TGF-β3 (35) EGF (122) HGF (49,154) inhibitors CST3 (46,47) SERPIN-A1, A3, B1, C1, G1 (46,47) SPINT1 (46,47) Other Coenzyme A (157) β-casomorphin (158) sCD14 (8,31,72,75,77,83,131,148,153) Other factors did not differ. …”

Section: Growth Factorsmentioning

confidence: 99%

Factors affecting breast milk composition and potential consequences for development of the allergic phenotype

Munblit

Boyle

Warner

2015

Clin Experimental Allergy

View full text Add to dashboard Cite

There is conflicting evidence on the protective role of breastfeeding in relation to allergic sensitization and disease. The factors in breast milk which influence these processes are still unclear and under investigation. We know that colostrum and breast milk contain a variety of molecules which can influence immune responses in the gut-associated lymphoid tissue of a neonate. This review summarizes the evidence that variations in colostrum and breast milk composition can influence allergic outcomes in the infant, and the evidence that maternal and environmental factors can modify milk composition. Taken together, the data presented support the possibility that maternal dietary interventions may be an effective way to promote infant health through modification of breast milk composition.

show abstract

Maternal country of birth and previous pregnancies are associated with breast milk characteristics

Cited by 31 publications

References 59 publications

Mount Pinatubo, Inflammatory Cytokines, and the Immunological Ecology of Aeta Hunter-Gatherers

Mount Pinatubo, Inflammatory Cytokines, and the Immunological Ecology of Aeta Hunter-Gatherers

Respiratory infections in preterm infants and subsequent asthma: a cohort study

Factors affecting breast milk composition and potential consequences for development of the allergic phenotype

Contact Info

Product

Resources

About