Maternal Cystatin C Serum is Higher in Women with Severe Preeclampsia

Isasari, Kurnia M; Pangemanan, Wim T.; Zulqarnain, Iskandar; Rahadiyanto, Kemas Yakub

doi:10.32771/inajog.v2i1.375

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Multiple regression analysis showed that the predictors significantly predict the outcome of DBP and only BMI remained as a single predictor which significantly influenced the DBP as depicted in Table 3 . Several investigations have indicated that serum Cystatin-C is a better marker for GFR than serum creatinine, in particular for individuals with small to moderate decreases in GFR [ 25 ]; only few investigations regarding Cystatin-C levels in pregnancy have been published [ 18 , 26 , 27 ]. Though, it would have been logical to expect a decreased value of serum Cystatin-C as the renal plasma flow increases during pregnancy leading to about 40% higher GFR, determined as the plasma clearance rate of the low molecular mass substance Iohexol [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Cystatin-C as a Marker for Renal Impairment in Preeclampsia

Niraula

Lamsal

Baral

et al. 2017

Journal of Biomarkers

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Preeclampsia is a devastating pregnancy-associated disorder characterized by the onset of hypertension, proteinuria, and edema with limited plausible pathophysiology known. Cystatin-C, a novel marker for the detection of renal impairment, is increased in preeclampsia at an early stage. This study was aimed to evaluate the diagnostic efficiency of Cystatin-C as an early marker of renal function in preeclampsia comparing it to the traditional renal markers. A hospital based comparative cross-sectional study was performed on 104 women (52 diagnosed cases of preeclampsia and 52 healthy pregnant women). Concentrations of Cystatin-C, creatinine, urea, and uric acid were measured in both the study groups. Mean serum Cystatin-C and uric acid levels were elevated in preeclampsia cases compared to controls (1.15 ± 0.37 versus 0.55 ± 0.12; 5.40 ± 1.44 versus 3.97 ± 0.68, resp.). ROC curve depicted that Cystatin-C had the highest diagnostic efficiency (sensitivity, 88.24%; specificity, 98.04%) compared to creatinine and uric acid. Serum Cystatin-C consequently seemed to closely reflect the renal functional changes, which are believed to lead to increased blood pressure levels and urinary excretion of albumin and may thus function as a marker for the stage of the transition between normal adaptive renal changes at term and preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Cystatin-C as a Marker for Renal Impairment in Preeclampsia

Niraula

Lamsal

Baral

et al. 2017

Journal of Biomarkers

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“…Thus, cystatin C levels can be highly sensitive in depicting a decrease in glomerular filtration rate. 17,18 Creatinine levels increased in patients with impaired renal function with severely decreased glomerular filtration rate, so normal serum creatinine cannot exclude an impaired renal function condition. Creatinine is unable to detect a decrease in glomerular filtration rate in the early stages of kidney dysfunction, therefore it is important to use new biomarkers such as Cystatin C since it has a superior diagnostic accuracy in preeclamp-sia compared to creatinine.…”

Section: Resultsmentioning

confidence: 99%

“…Creatinine is unable to detect a decrease in glomerular filtration rate in the early stages of kidney dysfunction, therefore it is important to use new biomarkers such as Cystatin C since it has a superior diagnostic accuracy in preeclamp-sia compared to creatinine. 4,13,18 A study of renal biopsy performed by Strevens et al (2003), found that cystatin C levels were correlated with the severity of renal structural changes (glomerular endoteliosis) that are typical in patients with preeclampsia. Research by Roberto Costa et al (2015), stated that there was a link between serum cystatin C levels with proteinuria levels.…”

Section: Resultsmentioning

confidence: 99%

The comparison of creatinine and cystatin C value in preeclampsia severity and neonatal outcome

Wantania

Winarto

2018

MOG

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Objectives: to compare the levels of creatinine and cystatin C with the severity of preeclampsia, and assess neonatal outcomes.Materials and Methods: Creatinine, cystatin C, and neonatal outcomes were assesed in 17 normotensive samples, 17 samples of mild preeclampsia and 17 samples of severe preeclampsia. Analysis of data with statistical tests of ANOVA and t test differences between 2 proportions.Results: The mean levels of creatinine in the normotensive group, mild preeclampsia, severe preeclampsia are 0.56 mg/dL, 0.67 mg/ dL, and 0.75 mg/dL, p=0.138; While on cystatin C are 0.82 mg/L, 1.03 mg/L and 1.32 mg/L, p=0.000. The adverse neonatal out-come wasn’t found in the normotensive group. In mild pre-eclampsia obtained 1 preterm birth and 1 intrauterine fetal death (IUFD), whereas in severe preeclampsia obtained 3 babies born preterm, 1 IUFD, and 1 intrauterine growth restriction (IUGR).Conclusion: levels of cystatin C was increased significantly in line with increased severity of preeclampsia, whereas creatinine was not increased significantly. Cystatin C is better than crea-tinine as a marker of renal dysfunction in preeclampsia patients. There was an increase in adverse neonatal outcomes in the group of preeclampsia.

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