Maternal detection of neonatal jaundice during birth hospitalization using a novel two-color icterometer

Olusanya, Bolajoko O.; Slusher, Tina M.; Imosemi, Donald; Emokpae, Abieyuwa A.

doi:10.1371/journal.pone.0183882

Cited by 28 publications

(27 citation statements)

References 28 publications

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“…Simple-to-use and cost-effective tools to assist mothers to detect jaundice in their newborns in home-settings well before the early symptoms of ABE are currently under development in LMICs. [74][75][76] Routine screening and monitoring for G6PD deficiency as well as Rh disease sensitisation should be emphasised especially in LMICs, more so as Rh disease has been successfully eliminated in developed countries.…”

Section: Primary Preventionmentioning

confidence: 99%

Neonatal hyperbilirubinaemia: a global perspective

Olusanya

Kaplan

Hansen

2018

The Lancet Child & Adolescent Health

216

195

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Hyperbilirubinaemia, presenting as jaundice, is a ubiquitous and frequently benign condition in newborn babies but is a leading cause of hospitalisation in the first week of life. In some infants jaundice can become severe, progressing to acute bilirubin encephalopathy and kernicterus with a substantial risk of neonatal mortality and long-term neurodevelopmental impairments. Severe hyperbilirubinaemia and its sequelae continue to occur in industrialised countries with functioning medical systems and a disproportionately high burden also persists in low-income and middle-income countries due primarily to delays in delivering effective treatments that are routinely available in high-income countries. In this Review we summarise up-to-date evidence on the epidemiology of neonatal jaundice including its global burden based on estimates of its prevalence, and both fatal and non-fatal health outcomes. We also discuss the management of severe hyperbilirubinaemia including the prevention of kernicterus, and highlight future directions for research.

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Section: Primary Preventionmentioning

confidence: 99%

Neonatal hyperbilirubinaemia: a global perspective

Olusanya

Kaplan

Hansen

2018

The Lancet Child & Adolescent Health

216

195

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“…Icterometer, a screening tool that can be used to detect the level of hyperbilirubinemia, is comprised of four yellow strips of paper that are pressed on the nose of neonates to predict bilirubin concentration (13). Bilistrip™, a two-color icterometer, uses the same method to determine the level of hyperbilirubinemia (14).…”

Section: Discussionmentioning

confidence: 99%

Detection of Neonatal Jaundice by Using an Android OS-Based Smartphone Application

Padidar¹,

Shaker²,

Amoozgar

et al. 2019

Iran J Pediatr

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Background: Neonatal jaundice resulting from raised blood bilirubin levels is one of the most common clinical conditions that needs medical attention. To initiate appropriate management that can both prevent and treat severe neonatal jaundice, screening methods that measure bilirubin level are warranted. Methods: In this study, we present an Android OS-based application for detecting neonatal jaundice. We used the application to detect jaundice in 113 neonates. Our smartphone-based estimation of bilirubin levels depends on a smartphone, a color calibration card, and a 100X zoom microscope clip. Our application was designed to acquire images of the newborn's forehead skin in a standardized manner, estimate the average R, G, B scores of the images that have been taken from the forehead skin and calibration card, and then convert them to hue, saturation, intensity (HSI) parameters. All these are performed offline; in this application, we used offline machine learning and regression techniques for analysis Results: Our smartphone-based estimation of bilirubin levels had a sensitivity of 68% and specificity of 92.3% for estimating the bilirubin levels of less than 10 mg/dL and sensitivity of 82.1% and specificity of 100% for estimating the bilirubin levels of less than 15 mg/dL. Our application-based estimation of bilirubin levels had the correlation of 0.479 with the total serum bilirubin values. Conclusions: Our results suggest that our smartphone-based application can serve as a promising screening tool for neonatal jaundice, and it can aid in determining neonates requiring a blood draw for measuring total serum bilirubin level.

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“…Without taking medications, it can disappear by itself in about 1–2 weeks after birth. Therefore, physiological jaundice causes a small impact on the baby’s overall health ( 3 ). Pathological jaundice, however, appears within 24 h of birth, and the baby’s serum level of bilirubin continues to rise over time.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Associated Markers of Neonatal Pathological Jaundice Due to Bacterial Infection

Sun

Wang

et al. 2021

ijph

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Background: To evaluate changes of associated markers in neonatal pathological jaundice due to bacterial infection in newborns, to provide an experimental basis for early diagnosis and treatment of neonatal pathological jaundice. Methods: A total of 126 newborns with neonatal pathological jaundice in the Pediatrics Department of Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University from Jan 2016 to Jun 2018 were enrolled. The patients were divided into bacterial infection group (76 cases with combined bacterial infection) and non-infection group (50 cases without bacterial infection). Peripheral blood was drawn from patients, and levels of inflammatory factors, levels of indexes of liver function and levels of cardiac markers were detected. Correlation between inflammatory factors and neonatal pathological jaundice was assessed. Results: The levels of WBC, hs-CRP and PCT in the bacterial infection group were significantly higher than those in the non-infected group (P<0.05). The level of TRF in the bacterial infection group was significantly lower than that in the non-infection group (P<0.01). In the bacterial infection group, the levels of WBC, hs-CRP, PCT, and TRF were positively correlated with the levels of CK, CKMB, LDH, and α-HBDB, respectively (all P<0.05). The TRF level after treatment was significantly higher than that before treatment (P<0.01). Conclusion: Markers such as WBC, hs-CRP, PCT, and TRF can be used as effective indicators in diagnosis of pathological jaundice due to bacterial infection in newborns. The combined testing of WBC, hs-CRP, PCT, and TRF was helpful for early diagnosis and early clinical intervention of neonatal pathological jaundice, which can lower the risk of clinical complications.

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Maternal detection of neonatal jaundice during birth hospitalization using a novel two-color icterometer

Cited by 28 publications

References 28 publications

Neonatal hyperbilirubinaemia: a global perspective

Neonatal hyperbilirubinaemia: a global perspective

Detection of Neonatal Jaundice by Using an Android OS-Based Smartphone Application

Evaluation of Associated Markers of Neonatal Pathological Jaundice Due to Bacterial Infection

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