Maternal diet during pregnancy and risk of allergic diseases in children up to 7–9 years old from Polish Mother and Child Cohort study

Brzozowska, Agnieszka; Podlecka, Daniela; Jankowska, Agnieszka; Król, Anna; Kaleta, Dorota; Trafalska, Elżbieta; Nowakowska‐Świrta, Ewa; Kałużny, Paweł; Hanke, Wojciech; Bal-Gierańczyk, Katarzyna; Kowalska, Małgorzata; Polańska, Kinga; Jerzyńska, Joanna

doi:10.1016/j.envres.2022.112682

Cited by 15 publications

(19 citation statements)

References 65 publications

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“…The included papers were based on 33 separate study populations, including six RCTs (eight papers 33,43,50‐55 ), 25 longitudinal cohorts (33 papers 17,34,35‐37,39‐41,44,56‐79 ) and two case–cohort studies 80,81 . Two RCTs (Project VDAART 53,54 and Rueter et al's studies 50,51 ) and seven prospective studies generated multiple publications.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 35 observational study articles, 29 explored the associations between vitamin D blood levels and eczema/food allergy, while six studies only reported vitamin D dietary intake 39,57,65,66,71,79 (Table S3). Two papers measured both vitamin D levels and dietary intake 36,75 .…”

Section: Resultsmentioning

confidence: 99%

“…Food allergy : Associations between vitamin D levels and food allergy outcomes were reported in 12 observational studies 17,35,41,63,67,70,75‐78,80,81 . The association between vitamin D dietary intake and food allergy was reported only in three studies 39,75,79 . Studies used several food allergy assessment methods, including SPT and oral food challenge up to 2 years old, 63,77,78,81 SPT and food allergy history report at 1 year 75 and 3 years old 17 and 9 years old, 35 SPT and peanut allergy under 6 years old, 80 the doctor diagnosed cow milk allergy up to 3 years old, 39 parental report of food allergy symptoms and IgE level testing at 1 year old, 70 and parental report of doctor diagnosis from 1 to 9 years old 41,76,79 (Table S3).…”

Section: Resultsmentioning

confidence: 99%

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Is antenatal or early‐life vitamin D associated with eczema or food allergy in childhood? A systematic review

Zeng

Shen

et al. 2023

Clin Experimental Allergy

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Objective To summarise the associations between antenatal or early‐life blood vitamin D and the development of eczema/food allergy in childhood. Design A systematic review and meta‐analyses were conducted to synthesize the published literature. Two reviewers independently performed the study selection and data extraction on Covidence. We assessed the risk of bias for observational studies by using the Newcastle‐Ottawa Scale and the Cochrane Risk of Bias tool for clinical trials. The certainty of the evidence was assessed using Grading of Recommendations, Assessment, Development and Evaluations (GRADE). Data sources We systematically searched PubMed and Embase from inception and April 2022. Eligibility criteria Human studies that investigated prospective associations between antenatal or early‐life blood vitamin D levels, dietary intake or supplementation and childhood eczema/food allergy. Results Forty‐three articles including six randomised controlled trials (RCTs) were included. Four RCTs of vitamin D supplementation during pregnancy showed no evidence of an effect on the incidence of eczema (pooled odds ratio [OR] = 0.85; 0.67–1.08, I2 = 6.7%, n = 2074). Three RCTs reported null associations between supplementation in pregnancy/infancy and food allergy. From six cohort studies, increasing cord blood vitamin D levels were associated with reduced prevalence of eczema at/close to age one (OR per 10 nmol/L increase = 0.89; 0.84–0.94, I2 = 0%, 2025 participants). We found no evidence of an association between maternal antenatal or infant vitamin D level or dietary intake and the development of food allergy or eczema in offspring. Conclusions We found an association between higher vitamin D levels in cord blood and reduced risk of eczema in cohort studies. Further trials with maternal and infant supplementation are needed to confirm if vitamin D supplementation can effectively prevent eczema or food allergy in childhood. Systematic review registration PROSPERO, No. CRD42013005559.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Is antenatal or early‐life vitamin D associated with eczema or food allergy in childhood? A systematic review

Zeng

Shen

et al. 2023

Clin Experimental Allergy

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“…Some studies reported no association between healthy eating, assessed by AHEI-P [ 11 , 12 ] or a principal component analysis (PCA) approach [ 26 , 27 ], and wheezing [ 11 , 26 , 27 ], asthma [ 11 , 27 ], eczema [ 11 , 26 , 27 ], or atopy [ 12 , 27 ]. However, other studies showed an increased risk of eczema at 1 [ 28 ] and 7–9 years [ 29 ] related to diet quality assessed by PCA and a priori score, respectively. A prospective longitudinal study showed an association between a higher HEI-2015 score during pregnancy and a lower prevalence of asthma in children over a 10-year follow-up [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Maternal Diet Quality during Pregnancy and Allergic and Respiratory Multimorbidity Clusters in Children from the EDEN Mother–Child Cohort

et al. 2022

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We investigated the associations between maternal diet quality and allergic and respiratory diseases in children. Analyses were based on 1316 mother–child pairs from the EDEN mother–child cohort. Maternal diet quality during pregnancy was assessed through a food-based score (the Diet Quality), a nutrient-based score (the PANDiet), and the adherence to guidelines for main food groups. Clusters of allergic and respiratory multimorbidity clusters up to 8 years were identified using Latent Class Analysis. Associations were assessed by adjusted multinomial logistic regressions. Four clusters were identified for children: “asymptomatic” (67%, reference group), “asthma only” (14%), “allergies without asthma” (12%), “multi-allergic” (7%). These clusters were not associated with mother diet quality assessed by both scores. Children from mothers consuming legumes once a month or less were at higher risk of belonging to the “multi-allergic” cluster (odds ratio (OR) (95% confidence interval (95%CI)) = 1.60 (1.01;2.54)). No association was found with other food groups or other clusters. In our study, allergic and respiratory multimorbidity in children was described with four distinct clusters. Our results suggest an interest in legumes consumption in the prevention of allergic diseases but need to be confirmed in larger cohorts and randomized control trials.

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“…While intake of allergenic foods and foods rich in n-6 polyunsaturated fatty acids during pregnancy may increase the risk of AD in offspring, foods rich in n-3 polyunsaturated fatty acids, fruits, vegetables, and prebiotics may decrease it [ 30 ]. Interestingly, an unhealthier diet—which is evaluated as a low score between Prudent Dietary Pattern (PDP) score and Western Dietary Pattern (WDP) score ((PDP-WDP) score)—during pregnancy was associated with a lower risk of atopic dermatitis and a higher risk of infections [ 31 ]. Moreover, maternal infection during gestation and exposure to antibiotics in early life was identified as a risk factor for the development of AD [ 32 , 33 ].…”

Section: The Role Of Exposome Components During Prenatal and Perinata...mentioning

confidence: 99%

The Imprint of Exposome on the Development of Atopic Dermatitis across the Lifespan: A Narrative Review

Grafanaki

Bania

Kaliatsi

et al. 2023

JCM

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Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects more than 200 million people worldwide, including up to 20% of children and 10% of the adult population. Although AD appears frequently in childhood and often continues into adulthood, about 1 in 4 adults develop the adult-onset disease. The prenatal period, early childhood, and adolescence are considered critical timepoints for the development of AD when the exposome results in long-lasting effects on the immune system. The exposome can be defined as the measure of all the exposures of an individual during their lifetime and how these exposures relate to well-being. While genetic factors could partially explain AD onset, multiple external environmental exposures (external exposome) in early life are implicated and are equally important for understanding AD manifestation. In this review, we describe the conceptual framework of the exposome and its relevance to AD from conception and across the lifespan. Through a spatiotemporal lens that focuses on the multi-level phenotyping of the environment, we highlight a framework that embraces the dynamic complex nature of exposome and recognizes the influence of additive and interactive environmental exposures. Moreover, we highlight the need to understand the developmental origins of AD from an age-related perspective when studying the effects of the exposome on AD, shifting the research paradigm away from the per se categorized exposome factors and beyond clinical contexts to explore the trajectory of age-related exposome risks and hence future preventive interventions.

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Maternal diet during pregnancy and risk of allergic diseases in children up to 7–9 years old from Polish Mother and Child Cohort study

Cited by 15 publications

References 65 publications

Is antenatal or early‐life vitamin D associated with eczema or food allergy in childhood? A systematic review

Is antenatal or early‐life vitamin D associated with eczema or food allergy in childhood? A systematic review

Maternal Diet Quality during Pregnancy and Allergic and Respiratory Multimorbidity Clusters in Children from the EDEN Mother–Child Cohort

The Imprint of Exposome on the Development of Atopic Dermatitis across the Lifespan: A Narrative Review

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