Maternal diet, gestational weight gain, and inflammatory markers during pregnancy

Hrolfsdottir, Laufey; Schalkwijk, Casper G.; Birgisdóttir, Bryndís Eva; Gunnarsdóttir, Ingibjörg; Maslova, Ekaterina; Granström, Charlotta; Strøm, Marin; Olsen, Sjúrður F.; Halldórsson, Thorhallur I.

doi:10.1002/oby.21617

Cited by 69 publications

(59 citation statements)

References 39 publications

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“…The significant role of low-grade inflammation has been confirmed in type 2 diabetes. Due to the similarity between T2DM and GDM, and the association between T2DM and inflammation, it has been hypothesised that inflammation could also be implicated in the pathophysiology of GDM [6,7]. Several studies have examined cytokine production in pregnant women and it has been shown that during pregnancy, the imbalance between the production of anti-inflammatory and pro-inflammatory cytokines may induce low-grade inflammation and insulin resistance [21].…”

Section: Discussionmentioning

confidence: 99%

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IL16 and IL18 gene polymorphisms in women with gestational diabetes

Tarnowski

Wieczorek²,

Dziedziejko

et al. 2017

Ginekol Pol

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Objectives: Gestational diabetes mellitus is a carbohydrate intolerance that occurs during pregnancy. Various inflammatory mediators are considered to be risk factors leading to GDM development. Among them are pro-inflammatory cytokines, such as IL16 and IL18. The aim of this study was to examine the association between IL16 and IL18 polymorphisms and GDM. Material and methods:This study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT). All samples were genotyped in duplicate using allelic discrimination assays with TaqMan® probes.Results: We observed that there was a decreased frequency of IL16 rs4778889 CC genotype carriers among women with GDM (CC vs. CT + TT: OR = 0.14; 95% CI = 0.02-1.15; p = 0.034). However, there was no significant difference in the distribution of alleles (C vs. T: OR = 0.81; 95% CI = 0.54-1.21; p = 0.30). There was a decreased frequency of the IL18 rs187238 G allele among GDM women (G vs. C: OR = 0.71; 95% CI = 0.53-0.96; p = 0.027). We also observed a decreased frequency of the IL18 rs1946518 T allele among women with GDM; however, this difference had only borderline statistical significance. We observed an association between IL18 rs187238, rs1946518 and BMI in pregnant women. Conclusions:The results of this study suggest that IL18 rs187238 and rs1946518 polymorphisms may be associated with an increased risk of GDM as well as with BMI in pregnant women.

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Section: Discussionmentioning

confidence: 99%

“…Recent studies suggest that genetic factors play important role in pathogenesis of GDM [5]. The role of the inflammatory response in the pathogenesis of GDM has been recently investigated [6]. Various inflammatory mediators are considered to be risk factors leading to GDM development [7,8], including cytokines.…”

Section: Introductionmentioning

confidence: 99%

IL16 and IL18 gene polymorphisms in women with gestational diabetes

Tarnowski

Wieczorek²,

Dziedziejko

et al. 2017

Ginekol Pol

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“…Cyclooxygenase and nitric oxide are important mediators of the inflammatory response in diabetes . Low grade inflammation has been shown to play a significant role in the pathogenesis of GDM …”

Section: Discussionmentioning

confidence: 99%

“…This disorder is associated with several maternal and neonatal complications and may induce the development of type 2 diabetes. Studies suggest that the pathogenesis of GDM is similar to diabetes type 2, where low‐grade inflammation plays a significant role . Genetic polymorphisms associated with inflammatory response are considered as risk factors for diabetes type 2 and GDM .…”

Section: Introductionmentioning

confidence: 99%

COX2 and NOS3 gene polymorphisms in women with gestational diabetes

Tarnowski

Tkacz

Dziedziejko

et al. 2017

The Journal of Gene Medicine

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“…Cut‐offs for sugar/artificially sweetened beverages and high dairy intake were set in line with Nordic studies. They show that high intake of these products is associated with high GWG (Hrolfsdottir et al, ; Olafsdottir et al, ; Renault et al, ) and adverse birth outcomes (Englund‐Ogge et al, ; Olsen et al, ; Zhu et al, )…”

Section: Participants and Methodsmentioning

confidence: 99%

Development of a dietary screening questionnaire to predict excessive weight gain in pregnancy

Hrolfsdottir

Halldórsson

Birgisdóttir

et al. 2018

Maternal & Child Nutrition

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Excessive gestational weight gain (GWG) is a risk factor for several adverse pregnancy outcomes, including macrosomia. Diet is one of the few modifiable risk factors identified. However, most dietary assessment methods are impractical for use in maternal care. This study evaluated whether a short dietary screening questionnaire could be used as a predictor of excessive GWG in a cohort of Icelandic women. The dietary data were collected in gestational weeks 11-14, using a 40-item food frequency screening questionnaire. The dietary data were transformed into 13 predefined dietary risk factors for an inadequate diet. Stepwise backward elimination was used to identify a reduced set of factors that best predicted excessive GWG. This set of variables was then used to calculate a combined dietary risk score (range 0-5). Information regarding outcomes, GWG (n = 1,326) and birth weight (n = 1,651), was extracted from maternal hospital records. In total, 36% had excessive GWG (Icelandic criteria), and 5% of infants were macrosomic (≥4,500 g). A high dietary risk score (characterized by a nonvaried diet, nonadequate frequency of consumption of fruits/vegetables, dairy, and whole grain intake, and excessive intake of sugar/artificially sweetened beverages and dairy) was associated with a higher risk of excessive GWG. Women with a high (≥4) versus low (≤2) risk score had higher risk of excessive GWG (relative risk = 1.23, 95% confi- Tian et al., 2016). Excessive GWG is also the primaryThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Maternal diet, gestational weight gain, and inflammatory markers during pregnancy

Abstract: Excessive GWG, as well as high intake of animal protein, was associated with higher concentrations of inflammatory factors.

Cited by 69 publications

References 39 publications

IL16 and IL18 gene polymorphisms in women with gestational diabetes

IL16 and IL18 gene polymorphisms in women with gestational diabetes

COX2 and NOS3 gene polymorphisms in women with gestational diabetes

Development of a dietary screening questionnaire to predict excessive weight gain in pregnancy

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