Maternal exposure to Di-n-butyl phthalate (DBP) aggravate gestational diabetes mellitus via FoxM1 suppression by pSTAT1 signalling

Chen, Min; Zhao, Sheng; Guo, Wei; Zhu, Yiping; Pan, Leyun; Xie, Zhiwen; Sun, Wen-Lan; Jiang, Junwei

doi:10.1016/j.ecoenv.2020.111154

Cited by 22 publications

(18 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, phthalate metabolites are less potent than BPA in inducing reduced viability and increased insulin release from the pancreatic β-cells in vitro (Weldingh et al 2017). In pregnant rats injected with streptozocin to induce GDM, di-n-butyl phthalate further exaggerated maternal hyperglycaemia and impaired glucose handling in vivo (Chen et al 2020). In addition, di-n-butyl phthalate impaired STAT1 signalling and led to inhibition of FoxM1 and reduced viability of β-cells in vitro (Chen et al 2020).…”

Section: Circadian Disruption During Pregnancymentioning

confidence: 99%

“…In pregnant rats injected with streptozocin to induce GDM, di‐ n ‐butyl phthalate further exaggerated maternal hyperglycaemia and impaired glucose handling in vivo (Chen et al . 2020). In addition, di‐ n ‐butyl phthalate impaired STAT1 signalling and led to inhibition of FoxM1 and reduced viability of β‐cells in vitro (Chen et al .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pregnancy‐induced changes in β‐cell function: what are the key players?

Salazar‐Petres

Sferruzzi‐Perri

2021

The Journal of Physiology

View full text Add to dashboard Cite

Maternal metabolic adaptations during pregnancy ensure appropriate nutrient supply to the developing fetus. This is facilitated by reductions in maternal peripheral insulin sensitivity, which enables glucose to be available in the maternal circulation for transfer to the fetus for growth. To balance this process and avoid excessive hyperglycaemia and glucose intolerance in the mother during pregnancy, maternal pancreatic β-cells undergo remarkable changes in their function including increasing their proliferation and glucose-stimulated insulin secretion. In this review we examine how placental and maternal hormones work cooperatively to activate several signalling pathways, transcription factors and epigenetic regulators to drive adaptations Esteban Salazar-Petres was awarded his PhD in 2018 from Universidad Austral de Chile. Since 2019, he has been a Postdoctoral Research Fellow (funded by a Beca-Chile, ANID fellowship) in the Sferruzzi-Perri lab, at the University of Cambridge. His current research is mainly focused on understanding the regulation of maternal endocrine and metabolic adaptations to pregnancy, with an emphasis on the involvement of changes in placental function and adverse environmental conditions such as obesity, diet and stress by using animal models and human pregnancy samples.

show abstract

Section: Circadian Disruption During Pregnancymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pregnancy‐induced changes in β‐cell function: what are the key players?

Salazar‐Petres

Sferruzzi‐Perri

2021

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Moreover, maternal exposure to phthalates was observed to lead to gestational hypertension and gestational diabetes mellitus (Werner et al, 2015;James-Todd et al, 2016). Finally, in vivo (Chen et al, 2020) and in vitro experimental studies (Zong et al, 2015) have reached the same conclusions as the population studies. Chen et al found that exposure to din-butyl phthalate (DBP) during pregnancy promotes the insurgence of gestational diabetes mellitus by signi cantly increasing the expression of protein pSTAT1 and inhibiting that of FOXM1; the authors also found that the said exposure causes a decrease in islets β cell viability .…”

Section: Introductionmentioning

confidence: 64%

Exposure Characteristics of Phthalate Metabolites Among The Zunyi Cohort of Pregnant Women in Southwest China

Zhou

Fang

Liu

et al. 2022

Preprint

View full text Add to dashboard Cite

Reported evidence has increasingly indicated that exposure to phthalates can cause adverse pregnancy outcomes. However, phthalate exposure levels among pregnant women remains unclear. We aimed to evaluate the concentrations of phthalate metabolites in urine samples of the Zunyi cohort of pregnant women from Southwest China. The study was conducted between August 2020 and July 2021, and urine samples were collected from 1003 pregnant women during their third trimester of pregnancy. The concentrations of nine phthalate metabolites in urine samples were then determined. Data on socio-demographic profiles of the participants, lifestyle during pregnancy, parity, and sampling season were collected using questionnaires. The detectable rate of phthalate metabolites ranged from 76–100%. On average, mono-butyl phthalate exhibited the highest median concentration (84.24 µg/L), while mono-benzyl phthalate exhibited the lowest median concentration (0.08 µg/L). Urine concentrations of phthalate metabolites were significantly higher in older, multiparous, higher-body mass index, higher-income, and passive-smoking during pregnancy participants. The levels of low-molecular-weight phthalate metabolites were highest during the summer. In light of our findings, phthalate metabolites present a demographic and seasonal differential distribution among the study population.

show abstract

“…However, the exact pathogenic mechanisms remain a matter of debate; for instance, the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort study published in 2021 on 415 pregnant women, based on the assessment of 11 urinary metabolites (using mass spectrometry), revealed that the direct association with the glucose profile was not statistically significant, however it was with weight gain which is an indirect contributor to insulin resistance as a potential contributor to DM (47). Murine experiments revealed another mechanism involving insulin-secreting pancreatic β-cells: Di-n-butyl phthalate upregulated the expression of phosphorylated signal transducer and activator of transcription 1 (pSTAT1) which inhibited Forkhead box protein M1 (FoxM1), as a toxicity mediator of β-cell dysfunction (48). Additional effects of plastic bottles and plastic containers of foods and drinks are transferred to the fetus producing disturbances in embryonic development and growth restriction, due to the epigenetic role of phthalates ingested by pregnant women (49).…”

Section: Dm: Past and Futurementioning

confidence: 99%

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

et al. 2022

View full text Add to dashboard Cite

Various plasticizers and nanomaterials have been linked to endocrine disruptors or endocrine-disrupting chemicals (EDCs) which represent a large, heterogeneous, yet incompletely understood group of structures acting on normal and pathological body pathways such as hormonal production, secretion, transport and receptor binding. By contrast, various applications of nanoparticles are currently under investigation since the delivery of useful drugs, particularly insulin in diabetes mellitus, is essential in case of insulin deficiency. The aim of the present review was to introduce and examine different plasticizers and nanomaterials with potential applications for diabetic patients (such as selenium or gold-based nanoparticles that help the oral delivery of insulin) or plasticizers/nanomaterials acting similarly to EDCs in relation to the human and animal body, particularly glucose metabolism impairment such as diabetes mellitus (DM). Bisphenol A is a chemical used worldwide; however, the effect of exposure varies with regard to the source, environment, time of exposure and the age of the organism. Daily exposure is mostly related to food and drinks stored in polycarbonate plastics. However, exposure may also be through the skin or through the maternal placenta or breast milk which are risk factors for the fetus and for the newborn. It exerts an estrogen-like profile, but it also induces insulin resistance by impairing peripheral insulin receptors or it decreases insulin secretion by acting at the level of insulin-secreting pancreatic β-cells. Phthalates, compounds of flexible plastics, act as EDCs via their human metabolites such as diethyl phthalate and derivative monoethyl phthalate. Their role in inducing gestational DM and weight gain/obesity during pregnancy has been showcased. The vast field of plasticizers and nanomolecules acting as endocrine disruptors is widely linked to clinical aspects of DM, a serious condition with a major population impact. The importance of understanding and using these agents and applications is reflected in saving numerous human lives. Contents 1. Introduction 2. Diabetes mellitus (DM): Past and future 3. Conclusions

show abstract

Maternal exposure to Di-n-butyl phthalate (DBP) aggravate gestational diabetes mellitus via FoxM1 suppression by pSTAT1 signalling

Cited by 22 publications

References 38 publications

Pregnancy‐induced changes in β‐cell function: what are the key players?

Pregnancy‐induced changes in β‐cell function: what are the key players?

Exposure Characteristics of Phthalate Metabolites Among The Zunyi Cohort of Pregnant Women in Southwest China

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

Contact Info

Product

Resources

About