Maternal-fetal transfer of ionized serum magnesium during the stress of labor and delivery: a human study.

Handwerker, Sara M.; Altura, Bella T.; Jones, Kathryn; Altura, Burton M.

doi:10.1080/07315724.1995.10718524

Cited by 17 publications

(8 citation statements)

References 14 publications

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“…Others have made similar observations. 38 Moreover, we found that the magnesium gradient was even greater (17%; P ¼ 0.001) in the setting of MgSO 4 tocolysis. 39 Thus, although obstetricians tend to make clinical decisions based on circulating magnesium levels in the mother, those in the fetus appear to be substantially higher and, thus, potentially more harmful, especially given the current state of our evolving knowledge.…”

Section: Magnesium Clearance In Babiesmentioning

confidence: 72%

Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor

Mittendorf

Dammann

2005

J Perinatol

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High-dosage, tocolytic magnesium sulfate (MgSO 4 ) administered to pregnant women during preterm labor can be toxic, and sometimes lethal, for their newborns (Cochrane Database of Systematic Reviews (relative mortality risk 2.82, 95% confidence interval 1.2-6.6)). Based on the results of the Magnesium and Neurologic Endpoints Trial and the work of many others, a unifying triangular concept is proposed to account for the increased prevalence of brain lesions, with their likely resultant mortality, in neonates and infants exposed to high-dose MgSO 4 in the context of preterm labor. We review the evidence that: (1) elevated circulating levels of serum ionized magnesium occurring in mothers, and therefore in their babies, at the time of delivery are associated with subsequent neonatal intraventricular hemorrhage (IVH); (2) neonatal IVH is strongly associated with lenticulostriate vasculopathy (LSV), an unusual mineralizing lesion involving the thalami and basal ganglia of the neonate; and, (3) exposure to 50 g or more of tocolytic MgSO 4 during preterm labor is associated with the development of LSV.

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Section: Magnesium Clearance In Babiesmentioning

confidence: 72%

Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor

Mittendorf

Dammann

2005

J Perinatol

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“…At cord Mg concentrations between 4 and 11 mg/dl, respiratory depression and motor depression have been observed. Clinically, serum Mg concentration in newborn infants usually exceeds maternal levels and leads to hypermagnesemia, with cord concentrations 70-100% higher than the maternal levels [19,[22][23][24] . Our study showed an initial rapid increase in the maternal magnesium concentration followed by a gradual increase in the fetal Mg concentration during the 3 h after MgSO 4 administration.…”

Section: Discussionmentioning

confidence: 99%

Fetal Reversed Constrictive Effect of Indomethacin and Postnatal Delayed Closure of the Ductus Arteriosus following Administration of Transplacental Magnesium Sulfate in Rats

Toyoshima¹,

Momma²,

Nakanishi³

2009

Neonatology

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Background: Magnesium sulfate (MgSO₄) is used therapeutically for eclampsia and tocolysis. Some reports have suggested a relationship between therapeutic MgSO₄ and patent ductus arteriosus (DA) in preterm infants. Objectives: To clarify patent DA induction by MgSO₄ in preterm infants, we studied the increase in serum Mg concentrations and fetal dilatation and postnatal delayed closure of the ductus, using transplacental MgSO₄ in rats. Methods: Fetal and neonatal ductus diameters were measured with a microscope and a micrometer after rapid whole-body freezing. In the postnatal study, 21-day pregnant dams were administered a subcutaneous injection of MgSO₄ 1–3 h before delivery, and the ductus was studied 0, 15, 30, 60 and 120 min after birth. In the fetal study, MgSO₄ (1 g/kg) and indomethacin (10 mg/kg) were simultaneously administered to 21-day dams and the fetal ductus was studied 1, 2 and 4 h later. Serum Mg concentration was measured in the dams and newborns. Results: Neonatal Mg concentrations increased from 3.8 to 4.7 and 5.8 mg/dl at 1 and 3 h after maternal administration of MgSO₄. Following MgSO₄ administration 3 h before birth, closure of the neonatal DA was delayed. The ductus diameter was 0.88 mm (0.80 mm in control) at 0 min, and 0.26 mm (0.08 mm in the control) at 60 min after birth. In the fetal study, MgSO₄ initially reversed and later attenuated the ductus-constricting effect of indomethacin. Conclusions: Hypermagnesemia induced by transplacental MgSO₄ attenuates the fetal ductus-constricting effects of indomethacin, and delays postnatal ductal closure in rats.

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“…Calcium and magnesium placental transfer is highly regulated by hormonal mechanisms in the mother, the placenta and the foetus. Serum concentrations of these cations are high at birth (8,9). Insofar as their relationship with lipids is concerned, epidemiological studies indicate that high dietary magnesium values are correlated with high serum high-density lipoproteincholesterol (HDL-cholesterol) and low serum total lipid levels (10).…”

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confidence: 99%

Selected trace elements and minerals in cord blood: association with lipids and lipoproteins at birth

Bastida

Vaquero

Veldhuizen

et al. 2000

SPAE

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Recent studies have found that some minerals are associated with lipoprotein metabolism, peroxidation and coronary heart disease. The present study was designed to obtain information on the relationship between the concentrations of minerals and trace elements and those of lipids, lipoproteins and apolipoproteins (Apo) in cord blood. Seventy-nine healthy singleton normoweight full-term newborns without foetal distress according to Apgar scores were studied. The quartile distribution of neonates, according to serum concentrations of the different minerals studied, displayed significant differences in lipid values between infants in the lowest and highest quartiles of: magnesium, for HDL-cholesterol, Apo A-I, Apo B and the HDL-cholesterol/Apo A-I ratio; iron, for HDL-cholesterol and the HDL-cholesterol/Apo A-I ratio; copper, for triglycerides and the LDL-cholesterol/Apo B ratio. With the exception of calcium, several significant correlations were found between the minerals and trace elements and the lipids, Apo and lipoproteins tested.

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Maternal-fetal transfer of ionized serum magnesium during the stress of labor and delivery: a human study.

Cited by 17 publications

References 14 publications

Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor

Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor

Fetal Reversed Constrictive Effect of Indomethacin and Postnatal Delayed Closure of the Ductus Arteriosus following Administration of Transplacental Magnesium Sulfate in Rats

Selected trace elements and minerals in cord blood: association with lipids and lipoproteins at birth

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