Maternal fluoxetine reduces hippocampal inflammation and neurogenesis in adult offspring with sex-specific effects of periadolescent oxytocin

Qiu, Wansu; Go, Kimberly A.; Wen, Yanhua; Duarte‐Guterman, Paula; Eid, Rand S.; Galea, Liisa A.M.

doi:10.1016/j.bbi.2021.06.012

Cited by 8 publications

(2 citation statements)

References 123 publications

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“…One study has reported that perinatal fluoxetine treatment avoided effects induced by maternal stress on sibling play behavior, increased socially aggressive behavior, and reduced time grooming with a novel con-specific in males [ 96 ]. Qiu et al [ 97 ] have confirmed that postpartum maternal fluoxetine treatment led to reduced proliferative DCX-positive cells in males and DCX-labeled post-mitotic cells in both sexes in the ventral DG.…”

Section: Utilizing Mouse Models To Understand the Impact Of Asd On Hi...mentioning

confidence: 95%

Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications

Liu

Gong

et al. 2023

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Autism spectrum disorder (ASD) is a cluster of heterogeneous neurodevelopmental condi- tions with atypical social communication and repetitive sensory-motor behaviors. The formation of new neurons from neural precursors in the hippocampus has been unequivocally demonstrated in the dentate gyrus of rodents and non-human primates. Accumulating evidence sheds light on how the deficits in the hippocampal neurogenesis may underlie some of the abnormal behavioral phenotypes in ASD. In this review, we describe the current evidence concerning pre-clinical and clinical studies supporting the significant role of hippocampal neurogenesis in ASD pathogenesis, discuss the possibility of improving hippocampal neurogenesis as a new strategy for treating ASD, and highlight the prospect of emerging pro‐neurogenic therapies for ASD.

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Section: Utilizing Mouse Models To Understand the Impact Of Asd On Hi...mentioning

confidence: 95%

Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications

Liu

Gong

et al. 2023

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show abstract

“…What calls for special attention is the subsequent risk of ASD with exposure to selective serotonin reuptake inhibitors during pregnancy. Recent findings underscored that maternal fluoxetine exposure impaired hippocampal LTP, spatial discrimination, and spatial learning in adult offspring ( 271 ), accompanied by decreased hippocampal neurogenesis and hippocampal IL-10, IFN-γ and IL-13 levels ( 272 ).…”

Section: Therapies That Positively Influence the Structure And Functi...mentioning

confidence: 99%

Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder

Long,

Li,

Liu

et al. 2024

Front. Psychiatry

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The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD). Individuals with ASD typically have impairments in hippocampus-dependent learning, memory, language ability, emotional regulation, and cognitive map creation. However, the pathological changes in the hippocampus that result in these cognitive deficits in ASD are not yet fully understood. In the present review, we will first summarize the hippocampal involvement in individuals with ASD. We will then provide an overview of hippocampal structural and functional abnormalities in genetic, environment-induced, and idiopathic animal models of ASD. Finally, we will discuss some pharmacological and non-pharmacological interventions that show positive impacts on the structure and function of the hippocampus in animal models of ASD. A further comprehension of hippocampal aberrations in ASD might elucidate their influence on the manifestation of this developmental disorder and provide clues for forthcoming diagnostic and therapeutic innovation.

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Altered in vivo early neurogenesis traits in patients with depression: Evidence from neuron-derived extracellular vesicles and electroconvulsive therapy

Xie,

Xu,

Yao

et al. 2024

Brain Stimulation

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Maternal fluoxetine reduces hippocampal inflammation and neurogenesis in adult offspring with sex-specific effects of periadolescent oxytocin

Cited by 8 publications

References 123 publications

Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications

Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications

Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder

Altered in vivo early neurogenesis traits in patients with depression: Evidence from neuron-derived extracellular vesicles and electroconvulsive therapy

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