Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure

Degroote, Stéphanie; Hunting, Darel J.; Baccarelli, Andrea A.; Takser, Larissa

doi:10.1016/j.pnpbp.2016.06.010

Cited by 90 publications

(66 citation statements)

References 42 publications

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“…Perinatal administration of antibiotics can affect offspring health and immune status in both humans and mouse models (Russell et al, 2013; Stensballe et al, 2013). Administration of nonabsorbable antibiotics to rodent dams resulted in shifts of both the maternal and offspring gut microbiomes and induced hypoactivity compared to controls (Degroote et al, 2016; Tochitani et al, 2016). Moreover, offspring exhibited anxiety-like behavior and deficits in locomotion (Tochitani et al, 2016).…”

Section: Major Processes In Neurodevelopment Coincide With Changes Inmentioning

confidence: 98%

“…Moreover, offspring exhibited anxiety-like behavior and deficits in locomotion (Tochitani et al, 2016). Similarly, offspring Wistar rats exhibited reduced social behavior and increased anxiety as a result of nonabsorbable antibiotics administration to dams early in gestation (Degroote et al, 2016). A recent report indicates that maternal diet may also change both the microbial population and behavior of offspring (Buffington et al, 2016), following clinical data showing an association between maternal obesity and an ASD diagnosis in children (Krakowiak et al, 2012).…”

Section: Major Processes In Neurodevelopment Coincide With Changes Inmentioning

confidence: 99%

“…The social deficit in these mice could be reversed by administration of Lactobacillus reuteri , found to be missing in the gut microbiome of high-fat diet offspring (Buffington et al, 2016). Similarly, behavioral deficits induced by antibiotic treatment during pregnancy could be rescued by cross-fostering offspring with control dams (Degroote et al, 2016; Tochitani et al, 2016). These examples indicate that maternal microbial populations can impact behavioral outcomes in the offspring.…”

Section: Major Processes In Neurodevelopment Coincide With Changes Inmentioning

confidence: 99%

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The Central Nervous System and the Gut Microbiome

Sharon

Sampson

Geschwind

et al. 2016

Cell

1,144

797

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Summary Neurodevelopment is a complex process governed by both intrinsic and extrinsic signals. While historically studied by researching the brain, inputs from the periphery impact many neurological conditions. Indeed, emerging data suggests communication between the gut and the brain in anxiety, depression, cognition and autism spectrum disorder (ASD). The development of a healthy, functional brain depends on key pre- and post-natal events that integrate environmental cues, such as molecular signals from the gut. These cues largely originate from the microbiome, the consortium of symbiotic bacteria that reside within all animals. Research over the past few years reveals that the gut microbiome plays a role in basic neurogenerative processes such as the formation of the blood-brain-barrier, myelination, neurogenesis, and microglia maturation, and also modulates many aspects of animal behavior. Herein, we discuss the biological intersection of neurodevelopment and the microbiome, and explore the hypothesis that gut bacteria are integral contributors to development and function of the nervous system, and the balance between mental health and disease.

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Section: Major Processes In Neurodevelopment Coincide With Changes Inmentioning

confidence: 98%

Section: Major Processes In Neurodevelopment Coincide With Changes Inmentioning

confidence: 99%

Section: Major Processes In Neurodevelopment Coincide With Changes Inmentioning

confidence: 99%

See 1 more Smart Citation

The Central Nervous System and the Gut Microbiome

Sharon

Sampson

Geschwind

et al. 2016

Cell

1,144

797

View full text Add to dashboard Cite

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“…Germ-free rodents typically exhibit deficits in both sociability and memory for social stimuli (indexed by preference for a novel social partner; Buffington et al, 2016;Desbonnet et al, 2014;Sgritta et al, 2019;Stilling et al, 2018; but see also Arentsen et al, 2015). Similar effects are observed following antibiotic depletion of the microbiota during development (Degroote et al, 2016;Desbonnet et al, 2015), while administration of certain probiotic species can enhance social behavior in various murine models of autism (Buffington et al, 2016;Hsiao et al, 2013;Sgritta et al, 2019) and inflammation-induced social withdrawal (D'Mello et al, 2015). In fruit flies (Drosophila melanogaster), both developing and mature individuals rely on microbiota-derived volatile compounds as social signals, influencing food and mating preference (Sharon et al, 2010;Venu et al, 2014).…”

Section: Behavioral and Cognitive Developmentmentioning

confidence: 85%

Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development

Cowan

Dinan

Cryan

2019

Child Psychology Psychiatry

128

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The gut microbiota is a vast, complex, and fascinating ecosystem of microorganisms that resides in the human gastrointestinal tract. As an integral part of the microbiota–gut–brain axis, it is now being recognized that the microbiota is a modulator of brain and behavior, across species. Intriguingly, periods of change in the microbiota coincide with the development of other body systems and particularly the brain. We hypothesize that these times of parallel development are biologically relevant, corresponding to ‘sensitive periods’ or ‘critical windows’ in the development of the microbiota–gut–brain axis. Specifically, signals from the microbiota during these periods are hypothesized to be crucial for establishing appropriate communication along the axis throughout the life span. In other words, the microbiota is hypothesized to act like an expected input to calibrate the development of the microbiota–gut–brain axis. The absence or disruption of the microbiota during specific developmental windows would therefore be expected to have a disproportionate effect on specific functions or potentially for regulation of the system as a whole. Evidence for microbial modulation of neurocognitive development and neurodevelopmental risk is discussed in light of this hypothesis, finishing with a focus on the challenges that lay ahead for the future study of the microbiota–gut–brain axis during development.

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“…Preclinical models are starting to shed light on the effect of antibiotic exposure on offspring neurodevelopment. Administration of antibiotics to pregnant rats caused impairments in social behaviour and pre-pulse inhibition of the offspring [68]. In mice, administration of non-absorbable antibiotics during pregnancy reduced the exploratory behaviour in the offspring [69].…”

Section: External Challenges To Maternal Microbiota Dynamicsmentioning

confidence: 99%

Microbiota and Neurodevelopmental Trajectories: Role of Maternal and Early-Life Nutrition

et al. 2019

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Pregnancy and early life are characterized by marked changes in body microbial composition. Intriguingly, these changes take place simultaneously with neurodevelopmental plasticity, suggesting a complex dialogue between the microbes that inhabit the gastrointestinal tract and the brain. The purpose of this chapter is to describe the natural trajectory of microbiota during pregnancy and early life, as well as review the literature available on its interaction with neurodevelopment. Several lines of evidence show that the gut microbiota interacts with diet, drugs and stress both prenatally and postnatally. Clinical and preclinical studies are illuminating how these disruptions result in different developmental outcomes. Understanding the role of the microbiota in neurodevelopment may lead to novel approaches to the study of the pathophysiology and treatment of neuropsychiatric disorders.

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Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure

Cited by 90 publications

References 42 publications

The Central Nervous System and the Gut Microbiome

The Central Nervous System and the Gut Microbiome

Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development

Microbiota and Neurodevelopmental Trajectories: Role of Maternal and Early-Life Nutrition

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