Maternal high fructose diet and neonatal immune challenge alter offspring anxiety-like behavior and inflammation across the lifespan

Bukhari, Syed Hussain F.; Clark, Olivia E.; Williamson, Lillie D.

doi:10.1016/j.lfs.2018.02.010

Cited by 29 publications

(21 citation statements)

References 35 publications

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“…Impairment of spatial learning and memory performance, together with reduced levels of BDNF and the up-regulation of histone deacetylase 4 in the nuclear fractions of hippocampal neurons, was shown in adult female offspring rats from a mother fed with a 60% high fructose diet during pregnancy and lactation [103]. Similarly, a maternal high fructose diet (60%) altered anxiety-like behavior in young and adult rats [104]. Moreover, impairment in cognitive performance, likely due to reduced hippocampal neurogenesis, was detected in 60-day-old Sprague Dawley rats born from mothers that received 20% fructose water in addition to standard chow during gestation and lactation [105].…”

Section: Fructose Cognitive Function Aging and Neurodegenerative Diseasesmentioning

confidence: 99%

Sweet but Bitter: Focus on Fructose Impact on Brain Function in Rodent Models

2020

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Fructose consumption has drastically increased during the last decades due to the extensive commercial use of high-fructose corn syrup as a sweetener for beverages, snacks and baked goods. Fructose overconsumption is known to induce obesity, dyslipidemia, insulin resistance and inflammation, and its metabolism is considered partially responsible for its role in several metabolic diseases. Indeed, the primary metabolites and by-products of gut and hepatic fructolysis may impair the functions of extrahepatic tissues and organs. However, fructose itself causes an adenosine triphosphate (ATP) depletion that triggers inflammation and oxidative stress. Many studies have dealt with the effects of this sugar on various organs, while the impact of fructose on brain function is, to date, less explored, despite the relevance of this issue. Notably, fructose transporters and fructose metabolizing enzymes are present in brain cells. In addition, it has emerged that fructose consumption, even in the short term, can adversely influence brain health by promoting neuroinflammation, brain mitochondrial dysfunction and oxidative stress, as well as insulin resistance. Fructose influence on synaptic plasticity and cognition, with a major impact on critical regions for learning and memory, was also reported. In this review, we discuss emerging data about fructose effects on brain health in rodent models, with special reference to the regulation of food intake, inflammation, mitochondrial function and oxidative stress, insulin signaling and cognitive function.

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Section: Fructose Cognitive Function Aging and Neurodegenerative Diseasesmentioning

confidence: 99%

Sweet but Bitter: Focus on Fructose Impact on Brain Function in Rodent Models

2020

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“…Chronic consumption of dietary sugar, specifically as added sugar, has been identified as a potential contributor to mental health conditions, including anxiety, depression, and cognitive decline in adolescents and adults [ 45 , 46 , 47 ]. Nevertheless, few studies have examined the influence of total and added sugar earlier in life, when the brain is most vulnerable to nutritional insults that may affect future neurodevelopmental outcomes [ 16 , 22 ]. Research on the prenatal and early postnatal periods is perhaps most pressing, as dietary sugar can conceivably be transmitted from the maternal diet to the developing fetus or nursing infant.…”

Section: Discussionmentioning

confidence: 99%

“…Maternally consumed dietary sugar has a direct line of transmission to the developing fetal brain, and the metabolism of dietary sugar may adversely affect the formation of early neural networks [ 17 ]. Indeed, in animal models of exposure, rat dams fed a sugar-sweetened solution bore pups expressing increased levels of inflammatory mediators in the hippocampus [ 22 ], which in turn was associated with poorer learning and memory [ 14 , 22 ]. Moreover, rodents fed a sugar-sweetened solution had increased expression of oxidative stress mediators in the frontal cortex [ 23 ], as well as lower levels of proteins that regulate early brain tissue organization and plasticity [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Prenatal Sugar Consumption with Newborn Brain Tissue Organization

et al. 2021

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Animal studies have shown that exposure to excess sugar during the prenatal and postnatal periods may alter early brain structure in rat pups. However, evidence in humans is lacking. The aim of this study was to determine associations of maternal total and added sugar intake in pregnancy with early brain tissue organization in infants. Adolescent mothers (n = 41) were recruited during pregnancy and completed 24 h dietary recalls during the second trimester. Diffusion tensor imaging was performed on infants using a 3.0 Tesla Magnetic Resonance Imaging Scanner at 3 weeks. Maps of fractional anisotropy (FA) and mean diffusivity (MD) were constructed. A multiple linear regression was used to examine voxel-wise associations across the brain. Adjusting for postmenstrual age, sex, birth weight, and total energy intake revealed that maternal total and added sugar consumption were associated inversely and diffusely with infant MD values, not FA values. Inverse associations were distributed throughout all of the cortical mantle, including the posterior periphery (Bs = −6.78 to −0.57, Ps < 0.001) and frontal lobe (Bs = −4.72 to −0.77, Ps ≤ 0.002). Our findings suggest that maternal total and added sugar intake during the second trimester are significantly associated with features of brain tissue organization in infants, the foundation for future functional outcomes.

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“…This increase in emotional reactivity also affected performance in cognitive tasks with prenatal feed restricted individuals less likely to learn the first reversal task in the T-maze if they had high levels of locomotion during social isolation and novel object tests. Similarly, there is evidence that the early life diet of an individual can influence cognitive performance, which, as shown by some studies, has the potential to last into adulthood ( 39 , 172 ). For example, Rytych et al ( 173 ) found that severely iron deficient piglets could not acquire a spatial T-maze task.…”

Section: Factors Contributing To Individual Variation In Cognitive Pementioning

confidence: 91%

Factors Influencing Individual Variation in Farm Animal Cognition and How to Account for These Statistically

et al. 2018

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For farmed species, good health and welfare is a win-win situation: both the animals and producers can benefit. In recent years, animal welfare scientists have embraced cognitive sciences to rise to the challenge of determining an animal's internal state in order to better understand its welfare needs and by extension, the needs of larger groups of animals. A wide range of cognitive tests have been developed that can be applied in farmed species to assess a range of cognitive traits. However, this has also presented challenges. Whilst it may be expected to see cognitive variation at the species level, differences in cognitive ability between and within individuals of the same species have frequently been noted but left largely unexplained. Not accounting for individual variation may result in misleading conclusions when the results are applied both at an individual level and at higher levels of scale. This has implications both for our fundamental understanding of an individual's welfare needs, but also more broadly for experimental design and the justification for sample sizes in studies using animals. We urgently need to address this issue. In this review, we will consider the latest developments on the causes of individual variation in cognitive outcomes, such as the choice of cognitive test, sex, breed, age, early life environment, rearing conditions, personality, diet, and the animal's microbiome. We discuss the impact of each of these factors specifically in relation to recent work in farmed species, and explore the future directions for cognitive research in this field, particularly in relation to experimental design and analytical techniques that allow individual variation to be accounted for appropriately.

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Maternal high fructose diet and neonatal immune challenge alter offspring anxiety-like behavior and inflammation across the lifespan

Cited by 29 publications

References 35 publications

Sweet but Bitter: Focus on Fructose Impact on Brain Function in Rodent Models

Sweet but Bitter: Focus on Fructose Impact on Brain Function in Rodent Models

Association of Prenatal Sugar Consumption with Newborn Brain Tissue Organization

Factors Influencing Individual Variation in Farm Animal Cognition and How to Account for These Statistically

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