Maternal Lactobacillus reuteri supplementation shifts the intestinal microbiome in mice and provides protection from experimental colitis in female offspring

Abstract

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Limosilactobacillus reuteri normalizes blood–brain barrier dysfunction and neurodevelopment deficits associated with prenatal exposure to lipopolysaccharide

“…Maternal L. reuteri (from late gestation to wean) has recently been shown to shape the microbiome of offspring in a sex-dependent manner. 73 Maternal L. reuteri induced a progressively increasing microbiome separation in the pups from controls in both female and male mice based on β diversity. However, the relative abundance of Lactobacillus, Akkermansia, Lachnoclostridium , and Bacteroides following maternal L. reuteri supplementation at P70 was significantly increased in female mice but not in male mice.…”

Cherry juice alleviates high-fat diet-induced obesity in C57BL/6J mice by resolving gut microbiota dysbiosis and regulating microRNA

“…29,30 Interestingly, low doses of cherry juice increased the abundance of some probiotics that were not as abundant in other groups, such as Dubosiella, Coriobacteriaceae-UCG-002, and Lachnospiraceae, which are thought to be related to beneficial bacteria, 31,41,42 and reduced the abundance of Enterobacter and Escherichia-Shigella, Notably, the HFD group had higher amounts of Lactobacillus and Blautia than any of the other groups, both of which are thought to be healthy bacteria. 43–45 Despite the fact that these two bacteria were less prevalent in HFD animals after high- and low-concentration cherry juice interventions, they were still present. We thought the two bacterial had a very small beneficial contribution to the mice's health compared to the negative effect of those harmful microbes in the HFD group.…”

“…Food & Function Shigella, Notably, the HFD group had higher amounts of Lactobacillus and Blautia than any of the other groups, both of which are thought to be healthy bacteria. [43][44][45] Despite the fact that these two bacteria were less prevalent in HFD animals after high-and low-concentration cherry juice interventions, they were still present. We thought the two bacterial had a very small beneficial contribution to the mice's health compared to the negative effect of those harmful microbes in the HFD group.…”

Disturbed Pediatric Gut Microbiome Maturation in the Developmental Origins of Subsequent Chronic Disease

“…This dysbiosis is thought to be the central mechanism by which antibiotics contribute to the development of chronic disease. On the contrary, the use of probiotics in early development could induce protection against the later onset of chronic disease, which has been proposed as a means of disease prevention (18). Multiple epidemiologic studies suggest that antibioticinduced dysbiosis in infancy promotes the development of chronic diseases (Table 1).…”