Maternal immunization with ovalbumin prevents neonatal allergy development and up-regulates inhibitory receptor FcγRIIB expression on B cells

Victor, Jefferson Russo; Muniz, Bruno Pacola; Fusaro, Ana Elisa; Brito, Cyro Alves de; Taniguchi, E. Futata; Duarte, Alberto J. S.; Sato, Maria Notomi

doi:10.1186/1471-2172-11-11

Cited by 52 publications

(70 citation statements)

References 34 publications

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“…As we previously described, MatAbs are passively transferred to their offspring, concomitant with anaphylactic IgE suppression in offspring [1–3]. Preconception OVA immunization could reduce total IgE production in offspring, in contrast with maternal Dp immunization.…”

Section: Discussionmentioning

confidence: 99%

Maternal immunization with ovalbumin or Dermatophagoides pteronyssinus has opposing effects on FcγRIIb expression on offspring B cells

Lira

Oliveira

et al. 2014

All Asth Clin Immun

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BackgroundOver the last decade, our group has demonstrated that murine preconception immunization with allergens has a protective effect on allergy development in offspring. The murine model used in the present study allowed us to compare allergy induction by ovalbumin (OVA) and dust mite extract from Dermatophagoides pteronyssinus (Dp).FindingsFemale mice were immunized with OVA or Dp. Pups from immunized and non-immune mothers were immunized at 3 days old (do) with the same antigen used for the maternal immunization. The offspring were analyzed at 20 do. Preconceptional immunization with OVA or Dp did not increase maternal IgE serum levels, although the immunizations induced an increase in allergen-specific IgG1 Ab levels. Offspring serum analyses revealed that maternal immunization with OVA suppressed IgE production only in offspring immunized with OVA. Both preconception immunization protocols inhibited cellular influx into the airways of immunized offspring compared with controls. Similar frequencies of offspring IgM + B cells were found in the OVA- and Dp-immunized groups compared with their respective control groups. Moreover, preconception immunization with OVA enhanced FcγRIIb expression on OVA-immunized offspring B cells. In contrast, decreased FcγRIIb expression was detected on Dp-immunized offspring B cells compared with cells from the offspring of non-immune mothers.ConclusionsTogether, these results show that preconception OVA immunization and Dp immunization can inhibit allergy development but have opposite effects on FcγRIIb expression on offspring B cells.

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Section: Discussionmentioning

confidence: 99%

Maternal immunization with ovalbumin or Dermatophagoides pteronyssinus has opposing effects on FcγRIIb expression on offspring B cells

Lira

Oliveira

et al. 2014

All Asth Clin Immun

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“…However, the in utero programming hypothesis pays attention to the maternal immune system and the in utero environment during pregnancy. The fetal immune system development appears to be affected by maternal exposure to allergens [29-31]. Additionally, it seems that certain endocrine disrupting substances play a role in this development.…”

Section: Discussionmentioning

confidence: 99%

Association between Household Income and Asthma Symptoms among Elementary School Children in Seoul

Choi¹,

Um²,

Sung-Hwa³

et al. 2012

Environ Health Toxicol

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ObjectivesThis study examined the association between socioeconomic factors and asthma symptoms.MethodsA total of 6,919 elementary school children in Seoul were enrolled in the study. Data were obtained from a web-based questionnaire survey. The questionnaire was based on the International Study of Asthma and Allergies in Childhood core module. The prevalence of wheeze in the past 12 months and severe asthma symptoms were obtained. The potential risk factors for asthma symptoms included household income and the number of siblings. A multiple logistic regression analysis was used to calculate the odds ratios (OR) and 95% confidence interval (CI) for the risk factors of asthma symptoms.ResultsThe prevalence of current wheeze (wheeze in the past 12 months) was 5.2%. Household income and asthma symptoms were inversely associated after adjusting for other potential risk factors (p for trend=0.03). This association was modified by the number of siblings. With two or more siblings, the effect of household income on asthma symptoms was not significant. However, low household income was still a significant variable for patients with fewer than two siblings (OR 1.41; 95% CI, 1.09-1.81).ConclusionsIt appears that childhood asthma disparity is dependent on household income. Therefore, policies to improve childhood health inequities should be emphasized.

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“…It has already been demonstrated in experimental animal models and in clinical studies that prenatal induction of allergen-specific IgG antibodies protects against allergen-induced sensitization and allergic inflammation in the offspring (Glovsky et al 1991;Jenmalm and Bjorksten 2000;Uthoff et al 2003;Flicker et al 2009;Victor et al 2010). …”

Section: Proof Of Concept Testing In Animal Modelsmentioning

confidence: 96%

Passive Immunization with Allergen-Specific Antibodies

Flicker

Gadermaier

Madritsch

et al. 2011

Vaccines Against Allergies

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The induction of allergen-specific IgG antibodies has been identified as a major mechanism responsible for the reduction of allergic inflammation in allergic patients treated by allergen-specific immunotherapy. Several studies suggest that allergen-specific IgG antibodies induced by vaccination with allergens block mast cell and basophil degranulation, IgE-facilitated allergen presentation to T cells and IgE production. The availability of recombinant allergens and technologies for the production of recombinant human antibodies allows engineering of allergen-specific antibodies which can be used for passive immunization (i.e., therapy) and eventually for the prevention of allergy (i.e., prophylaxis). This chapter summarizes data supporting the possible use of allergen-specific antibodies for treatment and prophylaxis. Finally, concrete approaches for the treatment and prevention of allergy based on blocking antibodies are envisioned.

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Maternal immunization with ovalbumin prevents neonatal allergy development and up-regulates inhibitory receptor FcγRIIB expression on B cells

Cited by 52 publications

References 34 publications

Maternal immunization with ovalbumin or Dermatophagoides pteronyssinus has opposing effects on FcγRIIb expression on offspring B cells

Maternal immunization with ovalbumin or Dermatophagoides pteronyssinus has opposing effects on FcγRIIb expression on offspring B cells

Association between Household Income and Asthma Symptoms among Elementary School Children in Seoul

Passive Immunization with Allergen-Specific Antibodies

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