Maternal indomethacin therapy in the treatmentof polyhydramnios

Mamopoulos, M.; Assimakopoulos, E.; Reece, E. Albert; Andreou, Alexandros; Zheng, Xue-Zheng; Mantalenakis, S.

doi:10.1016/0002-9378(90)90023-z

Cited by 52 publications

(19 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, there was no maternal or fetal complications so far noted in our study group. This was similar to other study 10 . The main limitation of our study is that the sample size is small and study of one and half year duration.…”

Section: Discussionsupporting

confidence: 93%

“…The multigravida was more as compared to primigravida in our study which is similar to study performed by Tariq S et al 13 and we cannot find obvious reason for this. There was significant reduction in AFI in our study which was similar to other study mentioned in the literature 7,8,10 . Our study was different from the other study as we had administered the indomethacin at the dose of 75 mg for 1 week only.…”

Section: Discussionsupporting

confidence: 92%

“…Indomethacin is an anti-prostagladin which causes reversible inhibition of cyclo-oxygenase enzyme. It causes the decrease production of amniotic fluid by increase absorption of fluid by lungs, reducing the urine output and also impairs the prostaglandin mediated response of renal vasculature 7,10,11 . The frequency of polyhydramnios was 1.7% in our study which corresponds with the other study mentioned in literature which showed the incidence of 1-2% respectively [2][3][4][5][6] .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Role of indomethacin in polyhydramnios

Shrestha¹,

Chawla

2013

Sri Lanka J Obstet & Gynae

View full text Add to dashboard Cite

Objective: To observe the role of indomethacin in polyhydramnios.Method: This was a prospective, longitudinal and analytical study conducted in Kathmandu University Hospital, Dhulikhel from 1st July 2011 to 1st of December 2012. There were 32 patients included in the study. Indomethacin was administered orally at the dose of 25 mg three times a day for 1 week. The patients were admitted for observation of clinical symptoms, fundal height, fetal status and amniotic fluid index measurement. After the delivery, baby was investigated for any abnormality of fetal circulation.Results: There were total of 2700 deliveries in 1 year. Among them 46 cases were of polyhydramnios. The frequency was 1.7%. Among the 46 cases, 32 (69.6%) were idiopathic who were included whereas 8 (17.4%) were of diabetes mellitus, 4 (8.7%) were Rh isoimmunisation, and 2 (4.3%) were fetal anomalies. The mean age group was 24.5+/ -4.2 years. There were total 10 (31.3%) patients presented at 29 weeks of gestation whereas only 5 (15.7%) patients at 32 weeks of gestation. Regarding the gravid index, 17 (53.1%) patients were primigravida. There was statistically significant reduction in amniotic fluid volume following 1 week administration of indomethacin. Conclusion:Though there are many modes of treatment for polyhydramnios, the 1 week therapy with indomethacin is equally beneficial.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Role of indomethacin in polyhydramnios

Shrestha¹,

Chawla

2013

Sri Lanka J Obstet & Gynae

View full text Add to dashboard Cite

show abstract

“…We decided to discontinue the NSAID administration at 30 weeks' gestation due to the possible risk of fetal complications and interestingly, the amniotic fluid production subsequently normalized. In several cases of polyhydramnios an increasing amniotic fluid volume has been reported after the discontinuation of NSAID [7] . Spontaneous resolution of polyhydramnios has been reported to occur only in mild cases not needing intervention [8,9] .…”

Section: Discussionmentioning

confidence: 99%

Acute Recurrent Polyhydramnios: A Combination of Amniocenteses and NSAID May Be Curative Rather than Palliative

Rode¹,

Bundgaard²,

Skibsted

et al. 2007

Fetal Diagn Ther

View full text Add to dashboard Cite

Acute recurrent polyhydramnios is a rare occurrence characterized by a poor fetal outcome. This is a case report describing a 34-year-old woman presenting with acute recurrent polyhydramnios. Treatment with non-steroidal anti-inflammatory drugs (NSAID) and therapeutic amniocenteses was initiated immediately and resulted in a decreased amniotic fluid production from 30 weeks’ gestation. Even after the discontinuation of NSAID treatment, the amniotic fluid production normalized, and the woman delivered a healthy boy at 39 weeks 2 days’ gestation. Amniotic prolactin was measured at three occasions using an enzyme-linked immunosorbent assay. As in normal pregnancies, amniotic prolactin levels decreased by 80% from highest to lowest value in this case of resolving acute recurrent polyhydramnios.

show abstract

“…The commonest age group affected was 21-30 years (71`%). In a study conducted by Mamopoulos et al (4) the mean age group of patients was28.9 years and the gestational age at the time of diagnosis was found to be 27.4+/-2.79weeks. In our study, the gestational age ranged from 20-42 weeks, majority diagnosed between 36 and 40 weeks.…”

Section: Jmscr Vol||05||issue||07||page 25661-25666||july 2017mentioning

confidence: 92%