Maternal inflammation, growth retardation, and preterm birth: Insights into adult cardiovascular disease

Rogers, Lynette K.; Velten, Markus

doi:10.1016/j.lfs.2011.07.017

Cited by 179 publications

(148 citation statements)

References 82 publications

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“…Preterm birth complications are the leading cause of death among children under 5 years of age, responsible for nearly 1 million deaths in 2013 [32]. In addition to its significant contribution to neonatal mortality, many survivors of preterm birth face a lifetime of disability, including learning disabilities, visual and hearing problems, as well as long-term physical health issues with a higher risk of non-communicable disease [32][33][34]. These certainly add significant costs to the economy as well as throw a heavy burden on families, society and the health system [35].…”

Section: Applications To Uterine Emg Signal Chracterizationmentioning

confidence: 99%

A Multivariate Multiscale Fuzzy Entropy Algorithm with Application to Uterine EMG Complexity Analysis

Ahmed

Chanwimalueang

Thayyil

et al. 2016

Entropy

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Abstract:The recently introduced multivariate multiscale entropy (MMSE) has been successfully used to quantify structural complexity in terms of nonlinear within-and cross-channel correlations as well as to reveal complex dynamical couplings and various degrees of synchronization over multiple scales in real-world multichannel data. However, the applicability of MMSE is limited by the coarse-graining process which defines scales, as it successively reduces the data length for each scale and thus yields inaccurate and undefined entropy estimates at higher scales and for short length data. To that cause, we propose the multivariate multiscale fuzzy entropy (MMFE) algorithm and demonstrate its superiority over the MMSE on both synthetic as well as real-world uterine electromyography (EMG) short duration signals. Based on MMFE features, an improvement in the classification accuracy of term-preterm deliveries was achieved, with a maximum area under the curve (AUC) value of 0.99.

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Section: Applications To Uterine Emg Signal Chracterizationmentioning

confidence: 99%

A Multivariate Multiscale Fuzzy Entropy Algorithm with Application to Uterine EMG Complexity Analysis

Ahmed

Chanwimalueang

Thayyil

et al. 2016

Entropy

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“…[1][2][3] In addition, in utero exposure to maternal obesity causes changes in the offspring's body composition, and cardiovascular and metabolic function as a result of developmental programming. [4][5][6] The placenta regulates maternal-fetal metabolism and produces perhaps the broadest array of information molecules (hormones, cytokines, and all other classes of signaling molecules) of any other organ except for the brain. 7 Placental function is now recognized as a critical regulator of fetal growth and development, as it communicates the maternal and intrauterine environment to the fetus, and as a mediator of fetal programming.…”

Section: Introductionmentioning

confidence: 99%

Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model

et al. 2016

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(2016) Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model, Autophagy, 12:5, 752-769, DOI: 10.1080/15548627.2016 ABSTRACTThe incidence of maternal obesity and its co-morbidities (diabetes, cardiovascular disease) continues to increase at an alarming rate, with major public health implications. In utero exposure to maternal obesity has been associated with development of cardiovascular and metabolic diseases in the offspring as a result of developmental programming. The placenta regulates maternal-fetal metabolism and shows significant changes in its function with maternal obesity. Autophagy is a cell-survival process, which is responsible for the degradation of damaged organelles and misfolded proteins. Here we show an activation of autophagosomal formation and autophagosome-lysosome fusion in placentas of males but not females from overweight (OW) and obese (OB) women vs. normal weight (NW) women. However, total autophagic activity in these placentas appeared to be decreased as it showed an increase in SQSTM1/p62 and a decrease in lysosomal biogenesis. A mouse model with a targeted deletion of the essential autophagy gene Atg7 in placental tissue showed significant placental abnormalities comparable to those seen in human placenta with maternal obesity. These included a decrease in expression of mitochondrial genes and antioxidants, and decreased lysosomal biogenesis. Strikingly, the knockout mice were developmentally programmed as they showed an increased sensitivity to high-fat diet-induced obesity, hyperglycemia, hyperinsulinemia, increased adiposity, and cardiac remodeling. In summary, our results indicate a sexual dimorphism in placental autophagy in response to maternal obesity. We also show that autophagy plays an important role in placental function and that inhibition of placental autophagy programs the offspring to obesity, and to metabolic and cardiovascular diseases.

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“…This excessive maternal nutrient intake has numerous adverse effects on both maternal and offspring health, independent of the postnatal diet (23). The detrimental impact to the health of offspring can be lifelong, particularly when combined with additional stressors into adulthood (23,44). Although the actions of excessive dietary intake on infant health are complex, of particular interest is the role of saturated fat, which has been shown to elicit both inflammatory and metabolic dysfunction in both mother and offspring (37,47).…”

mentioning

confidence: 99%

Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring

Pileggi

Segovia

Markworth

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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-A high-saturated-fat diet (HFD) during pregnancy and lactation leads to metabolic disorders in offspring concomitant with increased adiposity and a proinflammatory phenotype in later life. During the fetal period, the impact of maternal diet on skeletal muscle development is poorly described, despite this tissue exerting a major influence on life-long metabolic health. This study investigated the effect of a maternal HFD on skeletal muscle anabolic, catabolic, and inflammatory signaling in adult rat offspring. Furthermore, the actions of maternal-supplemented conjugated linoleic acid (CLA) on these measures of muscle phenotype were investigated. A purified control diet (CD; 10% kcal fat), a CD supplemented with CLA (CLA; 10% kcal fat, 1% total fat as CLA), a high-fat (HFD; 45% kcal fat from lard), or a HFD supplemented with CLA (HFCLA; 45% kcal fat from lard, 1% total fat as CLA) was fed ad libitum to female Sprague-Dawley rats for 10 days before mating and throughout gestation and lactation. Male offspring received a standard chow diet from weaning, and the gastrocnemius was collected for analysis at day 150. Offspring from HF and HFCLA mothers displayed lower muscular protein content accompanied by elevated monocyte chemotactic protein-1, IL-6, and IL-1␤ concentrations. Phosphorylation of NF-Bp65 (Ser 536 ) and expression of the catabolic E3 ligase muscle ring finger 1 (MuRF1) were increased in HF offspring, an effect reversed by maternal CLA supplementation. The present study demonstrates the importance of early life interventions to ameliorate the negative effects of poor maternal diet on offspring skeletal muscle development. maternal obesity; nuclear factor-B

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Maternal inflammation, growth retardation, and preterm birth: Insights into adult cardiovascular disease

Cited by 179 publications

References 82 publications

A Multivariate Multiscale Fuzzy Entropy Algorithm with Application to Uterine EMG Complexity Analysis

A Multivariate Multiscale Fuzzy Entropy Algorithm with Application to Uterine EMG Complexity Analysis

Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model

Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring

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