Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring

Pileggi, Chantal; Segovia, Stephanie A.; Markworth, James F.; Gray, Charles M.; Zhang, Xiaoyuan D.; Milan, Amber M.; Mitchell, Cameron J.; Barnett, Matthew P. G.; Roy, Nicole C.; Vickers, Mark H.; Reynolds, Clare M.; Cameron‐Smith, David

doi:10.1152/ajpregu.00351.2015

Cited by 19 publications

(17 citation statements)

References 52 publications

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“…80 SDFlard52YAFAT, LEP, HDL, TGPileggi C.A. 81 SDMlard52YABWSong Y. 82 SDMlard105YAFAT, BW, LEPLatouche C. 83 SDMlard63AFAT, BW, GLU, INSYang K.F.…”

Section: Resultsmentioning

confidence: 99%

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis

Tellechea

Mensegue

Pirola

2017

Sci Rep

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Numerous rodent studies have evaluated the effects of a maternal high-fat diet (HFD) on later in life susceptibility to Metabolic Syndrome (MetS) with varying results. Our aim was to quantitatively synthesize the available data on effects of maternal HFD around gestation on offspring’s body mass, body fat, plasma leptin, glucose, insulin, lipids and systolic blood pressure (SBP). Literature was screened and summary estimates of the effect of maternal HFD on outcomes were calculated by using fixed- or random-effects models. 362 effect sizes from 68 studies together with relevant moderators were collected. We found that maternal HFD is statistically associated with higher body fat, body weight, leptin, glucose, insulin and triglycerides levels, together with increased SBP in offspring later in life. Our analysis also revealed non-significant overall effect on offspring’s HDL-cholesterol. A main source of variation among studies emerged from rat strain and lard-based diet type. Strain and sex -specific effects on particular data subsets were detected. Recommendations are suggested for future research in the field of developmental programming of the MetS. Despite significant heterogeneity, our meta-analysis confirms that maternal HFD had long-term metabolic effects in offspring.

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“…80 SDFlard52YAFAT, LEP, HDL, TGPileggi C.A. 81 SDMlard52YABWSong Y. 82 SDMlard105YAFAT, BW, LEPLatouche C. 83 SDMlard63AFAT, BW, GLU, INSYang K.F.…”

Section: Resultsmentioning

confidence: 99%

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis

Tellechea

Mensegue

Pirola

2017

Sci Rep

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“…In previous studies, maternal obesity or obesogenic environment (e.g. high-fat diet) during pregnancy have been associated with reduced muscle mass [11,26], decreased myogenesis [13], lower protein content in muscle [27], and reduced muscle strength [12]. Moreover, maternal high-fat diet induces a 27% decrease in skeletal muscle precursor (SMP) cells [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of maternal weight during pregnancy on offspring muscle strength response to resistance training in late adulthood

Wasenius

Simonen

Penttinen

et al. 2018

Advances in Medical Sciences

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“…Other mechanisms of CLA on increased lean body mass have also been suggested. First, maternal CLA supplementation reversed high‐fat diet‐induced skeletal muscle atrophy in adult male rat offspring through reduction of muscle wasting (Pileggi et al, ). In addition, CLA reduced muscle atrophy by modulating inflammatory responses, such as the reduction of proinflammatory markers, tumor necrosis factor alpha (TNFα) (Halade, Rahman, & Fernandes, ; Park et al, ) and transcription regulator nuclear factor kappa B (NFκB) (Hommelberg et al, ).…”

Section: Dietary Fatty Acids On Mitochondrial Adaptationmentioning

confidence: 99%

Adaptations of Skeletal Muscle Mitochondria to Obesity, Exercise, and Polyunsaturated Fatty Acids

Chen

Yang

Park

2018

Lipids

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Mitochondria intricately modulate their energy production through the control of mitochondrial adaptation (mitochondrial biogenesis, fusion, and/or fission) to meet energy demands. Nutrient overload may result in dysregulated mitochondrial biogenesis, morphology toward mitochondrial fragmentation, and oxidative stress in the skeletal muscle. In addition, physical activity and diet components influence mitochondrial function. Exercise may stimulate mitochondrial biogenesis and promote mitochondrial fusion/fission in the skeletal muscle. Moreover, some dietary fatty acids, such as n-3 polyunsaturated fatty acids and conjugated linoleic acid, have been identified to positively regulate mitochondrial adaptation in the skeletal muscle. This review discusses the association of mitochondrial impairments and obesity, and presents an overview of various mechanisms of which exercise training and mitochondrial nutrients promote mitochondrial function in the skeletal muscle.

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Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring

Cited by 19 publications

References 52 publications

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis

Effect of maternal weight during pregnancy on offspring muscle strength response to resistance training in late adulthood

Adaptations of Skeletal Muscle Mitochondria to Obesity, Exercise, and Polyunsaturated Fatty Acids

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