Maternal Intake of Natto, a Japan's Traditional Fermented Soybean Food, during Pregnancy and the Risk of Eczema in Japanese Babies

Ozawa, Naoko; Shimojo, Naoki; Suzuki, Yôichi; Ochiai, Satoru; Nakano, Taiji; Morita, Yoshinori; Inoue, Yuzaburo; Arima, Takayasu; Suzuki, Shinichi; Kohno, Yoichi

doi:10.2332/allergolint.13-oa-0613

Cited by 23 publications

(29 citation statements)

References 17 publications

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“…Another example of maternal intake of specific foods affecting offspring allergic disease is that daily consumption of natto, a traditional Japanese fermented soya bean food, is associated with reduced eczema risk at six months of age . The effect remained significant when controlling for intakes of other foods, suggesting that natto consumption is not a surrogate marker of a protective maternal dietary pattern.…”

Section: In Utero Exposures That Influence Allergymentioning

confidence: 99%

Does allergy begin in utero?

Lockett

Huoman

Holloway

2015

Pediatric Allergy Immunology

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It has been recognized for centuries that allergic disease runs in families, implying a role for genetic factors in determining individual susceptibility. More recently, a range of evidence shows that many of these genetic factors, together with in utero environmental exposures, lead to the development of allergic disease through altered immune and organ development. Environmental exposures during pregnancy including diet, nutrient intake and toxin exposures can alter the epigenome and interact with inherited genetic and epigenetic risk factors to directly and indirectly influence organ development and immune programming. Understanding of these factors will be essential in identifying at-risk individuals and possible development of therapeutic interventions for the primary prevention of allergic disease. In this review, we summarize the evidence that suggests allergic disease begins in utero, together with possible mechanisms for the effect of environmental exposures during pregnancy on allergic disease risk, including epigenetics.

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Section: In Utero Exposures That Influence Allergymentioning

confidence: 99%

Does allergy begin in utero?

Lockett

Huoman

Holloway

2015

Pediatric Allergy Immunology

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“…Lactococcus lactis (18, 29) regulate immune responses by inducing cytokines in dendritic cells and B. subtilis natto regulate gut flora and immunity (32–34). We tested whether these probiotics induce Ca 2+ signaling in IECs.…”

Section: Resultsmentioning

confidence: 99%

Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo

et al. 2016

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Probiotics, such as lactic acid bacteria (LAB) and Bacillus subtilis var. natto, have been shown to modulate immune responses. It is important to understand how probiotic bacteria impact intestinal epithelial cells (IECs), because IECs are the first line of defense at the mucosal surface barrier and their activities substantially affect the gut microenvironment and immunity. However, to date, their precise mechanism remains unknown due to a lack of analytical systems available for live animal models. Recently, we generated a conditional Ca2+ biosensor Yellow Cameleon (YC3.60) transgenic mouse line and established 5D (x, y, z, time, and Ca2+) intravital imaging systems of lymphoid tissues including those in Peyer’s patches and bone marrow. In the present study, we further advance our intravital imaging system for intestinal tracts to visualize IEC responses against orally administrated food compounds in real time. Using this system, heat-killed B. subtilis natto, a probiotic TTCC012 strain, is shown to directly induce Ca2+ signaling in IECs in mice housed under specific pathogen-free conditions. In contrast, this activation is not observed in the Lactococcus lactis strain C60; however, when we generate germ-free YC3.60 mice and observe the LAB stimulation of IECs in the absence of gut microbiota, C60 is capable of inducing Ca2+ signaling. This is the first study to successfully visualize the direct effect of probiotics on IECs in live animals. These data strongly suggest that probiotic strains stimulate IECs under physiological conditions and that their activity is affected by the microenvironment of the small intestine, such as commensal bacteria.

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“…Употребление беременными женщинами продук-та натто, содержащего B.subtilis, статистически зна-чимо снижало частоту возникновения атопической экземы родившихся детей в течение первых 6 месяцев жизни [19].…”

Section: резюме в статье представлен обзор литературы о современных unclassified

Світовий Досвід Використання Бацил, Що Утворюють Спори, Для Лікування І Профілактики Харчової Алергії У Дітей

Ovcharenko¹,

Vertegel²,

Andrienko³

et al. 2021

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У статті подано огляд літератури щодо сучасних клінічних та експериментальних досліджень у галузі використання Bacillus subtilis і Bacillus licheniformis для лікування і профілактики харчової алергії у дітей. Наведені численні докази зв’язку порушень складу кишкової мікрофлори у дітей з різними алергічними захворюваннями в перші роки життя. Показано, що пробіотики, що містять Bacillus subtilis і Bacillus licheniformis, завдяки комплексному прямому й опосередкованому позитивному впливу сприяють запобіганню алергічним розладам. Дані мікроорганізми можуть тимчасово змінювати склад мікробіоти кишечника і потенційно зменшувати сприйнятливість організму дитини до алергенів. Така тактика перспективна і не порушує природних фізіологічних механізмів розвитку вікової імунної толерантності до різних антигенів, що запобігає формуванню харчової алергії у дітей.

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Maternal Intake of Natto, a Japan's Traditional Fermented Soybean Food, during Pregnancy and the Risk of Eczema in Japanese Babies

Abstract: High frequency intake of natto during pregnancy possibly reduces the incidence of eczema in children at 6 months of age.

Cited by 23 publications

References 17 publications

Does allergy begin in utero?

Does allergy begin in utero?

Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo

Світовий Досвід Використання Бацил, Що Утворюють Спори, Для Лікування І Профілактики Харчової Алергії У Дітей

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