Maternal lead exposure and risk of congenital heart defects occurrence in offspring

Liu, Zhen; Yu, Yu; Li, Xiaohong; Wu, Aimin; Mu, Mingdao; Li, Nana; Deng, Ying; Jin, Xi; Li, Shengli; Lin, Yuan; Chen, Xinlin; Wang, Fudi; Zhu, Jun

doi:10.1016/j.reprotox.2014.11.002

Cited by 56 publications

(29 citation statements)

References 49 publications

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“…In summary, no overall excess was observed in the group of structural defects examined in the offspring of this occupational cohort, but exposures to metals (and specifically lead) appear to be associated with increased risk for VSDs, an outcome that was not specifically of a priori interest. While a previous study reported an association between all septal defects and maternal hair lead levels (Liu et al, 2015), to our knowledge this is the first epidemiologic study to report an increased prevalence of VSDs in infants of men potentially exposed to lead. Numbers of all defects were small, and data on other factors such as take-home exposure, exposures at other worksites, nonwork exposures, family history of birth defects, and parental smoking were not available, hindering definitive assessment of the role of direct occupational exposures at the facility in VSDs and other health outcomes.…”

Section: Discussionmentioning

confidence: 59%

“…An increased risk that was not statistically significant was previously reported for parental (male and female) occupational lead exposure and total anomalous pulmonary venous return (Jackson et al, ). In another study, maternal lead exposure was associated with statistically significant increases in conotruncal defects, right and left ventricular outflow track obstruction, anomalous pulmonary venous return, septal defects, and other heart defects (Liu et al, ). Studies of lead and orofacial clefts (isolated cleft palate and cleft lip with or without cleft palate) have reported mixed results (Lorente et al, ; Vinceti et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Birth defects in infants born to employees of a microelectronics and business machine manufacturing facility

Silver

Pinkerton

Rocheleau

et al. 2016

Birth Defects Research

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Background Concerns about solvent releases from a microelectronics/business machine manufacturing facility in upstate New York led to interest in the health of former workers, including this investigation of birth defects in children of male and female employees. Methods Children born 1983 to 2001 to facility employees were enumerated and matched to New York State’s Congenital Malformations Registry. Reported structural birth defects were compared with numbers expected from state rates (excluding New York City), generating standardized prevalence ratios (SPRs). Exposure assessors classified employees as ever/never potentially exposed at the facility to metals, chlorinated hydrocarbons, and other hydrocarbons during windows critical to organogenesis (female workers) or spermatogenesis (male workers). Among workers, adjusted prevalence ratios were generated to evaluate associations between potential exposures and specific birth defects. Results External comparisons for structural defects were at expectation for infants of male workers (SPR = 1.01; 95% confidence interval [CI], 0.77–1.29; n = 60) and lower for births to female workers (SPR = 0.84; 95% CI, 0.50–1.33; n = 18). Among full-term infants of male workers, ventricular septal defects (VSDs) were somewhat elevated compared with the general population (SPR = 1.58; 95% CI, 0.99–2.39; n = 22). Within the cohort, potential paternal metal exposure was associated with increased VSD risk (adjusted prevalence ratio = 2.70; 95% CI, = 1.09–6.67; n = 7). Conclusion While overall SPRs were near expectation, paternal exposure to metals (primarily lead) appeared to be associated with increased VSD risk in infants. Take-home of occupational exposures, nonoccupational exposures, and chance could not be ruled out as causes. Case numbers for many defects were small, limiting assessment of the role of occupational exposures.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Birth defects in infants born to employees of a microelectronics and business machine manufacturing facility

Silver

Pinkerton

Rocheleau

et al. 2016

Birth Defects Research

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“…Each donor signed a patient consent form. The database utilized in the present study has been previously used to explore the relationship between pregnant women exposure to lead and copper in the first three months of pregnancy and risk of CHD in their offspring …”

Section: Methodsmentioning

confidence: 99%

“…To avoid the confounding influence of noncardiac defects, only isolated cases of CHD were assessed in this study. All cases with isolated CHD were classified into six subtypes based on anatomic lesions: (a) septal, (b) conotruncal, (c) left‐sided obstructive, (d) right‐sided obstructive, (e) anomalous venous return, and (f) other cardiac structural abnormalities …”

Section: Methodsmentioning

confidence: 99%

High maternal selenium levels are associated with increased risk of congenital heart defects in the offspring

Guo

Zhu

et al. 2019

Prenatal Diagnosis

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Objective To examine whether maternal hair or cord blood selenium levels are associated with infant congenital heart defects (CHDs). Method A hospital‐based case‐control study was performed with samples collected from 2010 to 2014. Selenium levels in maternal hair and fetal cord serum were measured using Inductively Coupled Plasma‐Mass Spectrometry (ICP‐MS). Data from medical records of infants with CHDs were collected. Logistic regression analysis was employed to examine the independent association between maternal selenium exposure and fetal CHD. Results In total, 888 pregnant women were included in this study. Median (interquartile range) selenium levels in of maternal hair was similar in the control and CHD group. A significant association was detected between increased maternal hair selenium concentration and CHDs in offspring (adjusted odds ratio [aOR] 3.57, 95 %CI, 1.90‐6.70). The association was present in all CHD groups, including septal defects, conotruncal defects, left ventricular outflow tract obstruction, right ventricular outflow tract obstruction, and anomalous pulmonary venous return. Conclusion High maternal selenium level is significantly associated with the occurrence of fetal CHD.

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“…The potential dose-response relationship is also presented. 30 Arsenic exposure: In several studies, chronic exposure to arsenic through drinking water is linked to developmental anomaly of CHDs. Jin et al 31 found arsenic concentrations ≥62.03 ng/g were associated with increased risk for almost every CHD subtype, with a dose-response relationship.…”

Section: Effects Of Environmental Chemical Contamination In Congenitamentioning

confidence: 99%

Noninherited Risk Factors of Congenital Heart Defects in Offspring: A Revi

Mamun

Hussain

Hasan

et al. 2017

Bangladesh J Child Health

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Maternal lead exposure and risk of congenital heart defects occurrence in offspring

Cited by 56 publications

References 49 publications

Birth defects in infants born to employees of a microelectronics and business machine manufacturing facility

Birth defects in infants born to employees of a microelectronics and business machine manufacturing facility

High maternal selenium levels are associated with increased risk of congenital heart defects in the offspring

Noninherited Risk Factors of Congenital Heart Defects in Offspring: A Revi

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