Maternal levels of perfluorinated chemicals and subfecundity

Fei, Chunyuan; McLaughlin, Joseph K.; Lipworth, Loren; Olsen, Jørn

doi:10.1093/humrep/den490

Cited by 315 publications

(241 citation statements)

References 27 publications

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“…Nearly all compounds measured in the present study can be categorized as endocrine disruptors, some of which have been suspected to affect the reproductive system in males, as well as play an important role in the decline of semen quality and increase in testicular cancer in Denmark (61)(62)(63). Effects on reproduction in females have also been reported for compounds measured in the present study (64)(65)(66)(67). Furthermore, neurological and immunological effects have been associated to chemical exposure (28,58,68,69).…”

Section: All Biomarkers In the Studysupporting

confidence: 62%

Biomonitoring of Danish school children and mothers including biomarkers of PBDE and glyphosate

Knudsen

Hansen

Mizrak

et al. 2017

Reviews on Environmental Health

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AbstractBackground:The Danish part of the large European Human biomonitoring pilot project Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale (DEMOCOPHES) investigated the urine, hair and blood concentrations of 66 different environmental chemicals in a group of 145 Danish school children aged 6–11 years and their mothers from rural and urban areas in autumn 2011. Some – but not all – results were published; however, the concurrence of the chemicals has not been assessed.Methods:The measured concentrations of polybrominated diphenyl ethers (PBDEs) and glyphosate is assessed to complete the investigation of all 66 chemicals in DEMOCOPHES. The concentrations of PBDEs were measured in plasma samples of 143 mothers and 116 children. Glyphosate was measured in a subsample of 27 urine samples. Previously assessed chemicals were polychlorinated biphenyls (PCBs), and polyfluoroalkyl substances (PFASs) analyzed in blood samples, mercury analyzed in hair, and phthalate metabolites, parabens, phenols, cadmium, paracetamol and cotinine analyzed in urine samples. Differences in concentrations between mothers and children were assessed, and the associations between the concentrations of the different environmental chemicals. investigated by correlation analysis.Results:PBDE47 was found in relatively high levels compared with previous Danish results in both mothers and children, with a significantly higher level in the children compared to their mothers. Glyphosate in concentrations around 1 ng/mL was detected in all 27 samples. The analyzed environmental exposures seem to follow a pattern where chemicals within the same classes are strongly correlated and where children and mothers are exposed to the same chemicals.Conclusion:The correlations between the measured environmental chemicals indicate that a specific exposure pattern may exist, where people who are highly exposed to one class of environmental chemicals also may be highly exposed to certain other classes. As some of the compounds were measured in higher levels in children compared to mothers, increased focus also on the exposure in young children is recommended. For more detailed investigation of specific exposure sources more studies with increased power and detailed questionnaires should be developed.

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Section: All Biomarkers In the Studysupporting

confidence: 62%

Biomonitoring of Danish school children and mothers including biomarkers of PBDE and glyphosate

Knudsen

Hansen

Mizrak

et al. 2017

Reviews on Environmental Health

View full text Add to dashboard Cite

show abstract

“…Weak associations between PFOA and PFOS exposure and reduced fertility in humans have been observed (Fei et al, 2009;Whitworth et al, 2012). A few human studies have also shown positive but weak associations between PFOA or PFOS exposure and preeclampsia, early menopause, delayed puberty onset, and semen quality, while other studies have shown no association with some of these reproductive parameters (Fei et al, 2009;Stein et al, 2009;Knox et al, 2011;Lopez-Espinosa et al 2011;Joensen et al 2009;Raymer et al 2012;Louis et al 2013). However, a recent prospective study shows an association between in utero exposure to PFOA and semen quality and reproductive hormones in male offspring 20 years later.…”

Section: Reproductive and Developmental Toxicitymentioning

confidence: 99%

PFAS in Paper and Board for Food Contact

et al. 2018

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“…Sperm concentration, total sperm count and semen volume was not consistently associated with PFOA. Couple fecundity and time to pregnancy (TTP) were evaluated in the Danish National Birth Cohort study (n = 1,240) (Fei et al, 2009). The evaluation of TTP showed increased risk of irregular menstrual cycles in the upper three quartiles of PFOA relative to the lowest quartile and an increase in mean PFOA with longer TTP.…”

Section:  Reproductive Effectsmentioning

confidence: 99%