Maternal multivitamin use and orofacial clefts in offspring

Itikala, Padmaja R.; Watkins, Margaret; Mulinare, Joseph; Moore, Cynthia A.; Liu, Yecai

doi:10.1002/1096-9926(200102)63:2<79::aid-tera1013>3.0.co;2-3

Cited by 151 publications

(61 citation statements)

References 23 publications

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“…Because multivitamins contained different vitamins and minerals and the composition and dose of vitamins and minerals in multivitamins vary, it was difficult to identify which component(s) of multivitamins possibly contributed to risk reduction. Folic acid is a likely candidate [32]. Type of multivitamins reported in our study was various and a number of which contained folic acid.…”

Section: Discussionmentioning

confidence: 93%

Association of Parental Environmental Exposures and Supplementation Intake with Risk of Nonsyndromic Orofacial Clefts: A Case-Control Study in Heilongjiang Province, China

Tian²,

Jiao

et al. 2015

Nutrients

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The aim of present study was to check the possible association of potential parental environmental exposures and maternal supplementation intake with the risk of nonsyndromic orofacial clefting (NSOC). A retrospective study comprised 499 cases and 480 controls was conducted in Heilongjiang Province. Chi-square analysis and unconditional multiple logistic regression were used in the study. The results showed that maternal history of fever and the common cold without fever (ORCL/P = 3.11 and 5.56, 95%CI: 1.67–5.82 and 2.96–10.47, ORCPO = 3.31 and 8.23, 95%CI: 1.58–6.94 and 4.08–16.95), paternal smoking and alcohol consumption (ORCL/P = 2.15 and 5.04, 95%CI: 1.37–3.38 and 3.00–8.46, ORCPO = 1.82 and 4.40, 95%CI: 1.06–3.13 and 2.50–7.74), maternal exposure to organic solvents, heavy metals, or pesticides (ORCL/P = 6.07, 5.67 and 5.97, 95%CI: 1.49–24.76, 1.34–24.09 and 2.10–16.98, ORCPO = 10.65, 7.28 and 3.48, 95%CI: 2.54–44.67, 1.41–37.63 and 1.06–11.46) and multivitamin use during the preconception period (ORCL/P = 0.06, 95%CI: 0.02–0.23, ORCPO = 0.06, 95%CI: 0.01–0.30) were associated with cleft lip or without cleft palate (CL/P) and cleft palate only (CPO). Maternal history of skin disease and negative life events (ORCL/P = 12.07 and 1.67, 95%CI: 1.81–80.05 and 1.95–2.67) were associated with CL/P. Some potential parental hazardous exposures during the periconception period and maternal use of multivitamins during the preconception period were associated with risk of NSOC.

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Section: Discussionmentioning

confidence: 93%

Association of Parental Environmental Exposures and Supplementation Intake with Risk of Nonsyndromic Orofacial Clefts: A Case-Control Study in Heilongjiang Province, China

Tian²,

Jiao

et al. 2015

Nutrients

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“…[3][4][5][6][7] Some ambiguity in previous studies may reflect the relatively weaker association of folic acid with clefts compared with neural tube defects. Furthermore, most of the earlier clefts studies were not specifically designed to test the folic acid hypothesis, few were able to distinguish intake of folic acid from intake of multivitamins, and none sought documentation of reported intake.…”

Section: Strengths and Weaknessesmentioning

confidence: 99%

“…1 Even before folic acid deficiency had been linked to neural tube defects, it was known to produce facial clefts in rodents. 2 However, studies of an association with facial clefts in humans have provided inconsistent results, [3][4][5][6][7][8] and the question remains unresolved. 9 This question is especially relevant in countries where fortification of foods with folic acid has not been allowed.…”

Section: Introductionmentioning

confidence: 99%

Folic acid supplements and risk of facial clefts: national population based case-control study

Wilcox

Lie

Solvoll

et al. 2007

BMJ

360

237

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“…Folate has long been considered one such factor. A number of observational studies (Czeizel et al, 1996, 1999; Itikala et al, 2001; Loffredo et al, 2001; Shaw et al, 1995; Tolarova and Harris, 1995; van Rooij et al, 2004; Boyles et al, 2008), although not all (Hayes et al, 1996; Czeizel, 1993), have reported lower rates of clefts in the offspring of mothers who took folic acid during the periconceptional period. Some studies have found a decline in cleft rates since food fortification with folic acid began (Canfield et al, 2005; Yazdy et al, 2007), although others have not found a change (Ray et al, 2003; Simmons et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Folate‐related gene polymorphisms as risk factors for cleft lip and cleft palate

Mills

Molloy

Parle‐McDermott

et al. 2008

Birth Defects Research

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BACKGROUND-Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folaterelated genes associated with clefts have, however, often been inconclusive. This study examined four SNPs related to folate metabolism (MTHFR 677 C→T, MTHFR 1298 A→C, MTHFD1 1958 G→A, and TC II 776 C→G) in a large Irish population to clarify their relationship with clefts.

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Maternal multivitamin use and orofacial clefts in offspring

Cited by 151 publications

References 23 publications

Association of Parental Environmental Exposures and Supplementation Intake with Risk of Nonsyndromic Orofacial Clefts: A Case-Control Study in Heilongjiang Province, China

Association of Parental Environmental Exposures and Supplementation Intake with Risk of Nonsyndromic Orofacial Clefts: A Case-Control Study in Heilongjiang Province, China

Folic acid supplements and risk of facial clefts: national population based case-control study

Folate‐related gene polymorphisms as risk factors for cleft lip and cleft palate

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