Maternal, newborn, child and adolescent health: challenges for the next decade

Costello, Anthony; Naimy, Zainab

doi:10.1093/inthealth/ihz051

Cited by 14 publications

(5 citation statements)

References 23 publications

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“… 80 Infections represent the main cause of morbidity and mortality in neonates and young infants worldwide and preventive measures such as vaccines could reduce childhood mortality. 74 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 The use of vaccines in neonates that carry the largest disease burden, however, is less effective calling for strategies to accelerate immune maturation and improve the immune response to the vaccine antigen in particular at mucosal body surfaces accessible to non-parenteral vaccine administration. 80 …”

Section: Discussionmentioning

confidence: 99%

M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch

Torow

Hitch

et al. 2023

Immunity

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Section: Discussionmentioning

confidence: 99%

M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch

Torow

Hitch

et al. 2023

Immunity

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“…A mechanistic understanding of neonate-specific features and their biological relevance as well as the ability to manipulate immune reactivity might ultimately facilitate targeted interventional strategies to prevent or treat diseases of the term and preterm human neonate (Kollmann et al, 2020). Infections represent the main cause of morbidity and mortality in neonates and young infants worldwide and preventive measures such as vaccines could reduce childhood mortality (Costello and Naimy, 2019; Countdown to 2030 Collaboration, 2018; G. B. D. Child Mortality Collaborators, 2016; Kotloff et al, 2013; Levine et al, 2020; MacLennan and Saul, 2014; Mathers et al, 2017; Oppong et al, 2020; Prudden et al, 2020). The use of vaccines in neonates that carry the largest disease burden, however, is less effective calling for strategies to accelerate immune maturation and improve the immune response to the vaccine antigen in particular at mucosal body surfaces accessible to non-parenteral vaccine administration (Kollmann et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Neonatal Peyer’s patch cDC activation as a pacemaker of postnatal immune maturation

Torow

Hitch

et al. 2022

Preprint

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Marked differences exist between the mucosal immune system of the neonate and adult host. The pronounced influence of the enteric microbiota in adults suggests a causal relationship between postnatal colonization and immune maturation. However, using metagenomic, metaproteomic, and functional immunological analyses we demonstrate an early presence of bacteria and immunogenic microbial antigens preceding immune maturation in the small intestine, the primary inductive site of intestinal immunity. Instead, transcriptomic, flow cytometric and histological analysis indicated neonatal Peyer’s patch (PP) mononuclear phagocytes (MNP) as rate limiting factor of postnatal immune maturation. Despite the early presence of MNPs, conventional dendritic cells (cDC) of type 1, 2a and 2b exhibited significant age-dependent differences in tissue distribution and cellular composition. Single cell transcriptional profiling and functional assays revealed decreased antimicrobial and antigen processing/presentation capacity, an overall retarded cell maturation and reduced antigen uptake. In cDC2a this resulted in a reduced proportion of CCR7+ migratory cells and a consequent defect in CD4 T cell priming. Interestingly, transcriptional profiling of neonatal DC subsets identified reduced expression of type I interferon (IFN)-stimulated genes (ISG). Type I IFN induction by oral administration of the TLR7 agonist R848 accelerated MNP maturation and enhanced cognate antigen CD4 T cell priming. However, humoral responses to oral vaccination in the presence of R848 were significantly reduced. Together, our results identify PP MNP maturation as pacemaker of postnatal mucosal immune priming, indicate the biological role of delayed maturation and demonstrate that targeted interventional strategies allow manipulation of mucosal responses in early life.

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“…Due to all of these changes, there is an increasing interest for in-depth studies on of this phase, especially with regard to health aspects. Also, this population has increased in recent years, and it is already well known that the health-related habits during the period of adolescence will have a lasting impact on the adults they will become, and the children of the next generation [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Gamification as a health education strategy of adolescents at school: Protocol for a systematic review and meta-analysis

dos Santos,

Ríos,

de Medeiros

et al. 2023

PLoS ONE

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The objective of the study is to present a systematic review and meta-analysis protocol for evaluating the effects of health education gamification-based interventions, on health parameters (food consumption, sleep quality and physical activity) of adolescent students. This protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42022373833). The search will be performed in the following databases: MEDLINE, Embase, Scopus, ERIC, ScienceDirect, Web of Science, Cochrane, LILACS, APA, and ADOLEC. Intervention studies (clinical trials ‐ randomized or non-randomized) and quasi-experimental studies will be included. The risk of bias will be assessed using the Risk of Bias in Non-randomized Studies of Interventions tool for randomized controlled trials, non- randomized controlled trials and quasi-experimental trials. Two independent researchers will conduct all assessments, and any disagreements will be consulted with a third reviewer. Data analysis and synthesis will be analyzed using RevMan 5.4.1 software. We will conduct the study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guideline. The review will summarize the current evidence on gamification health education changes in parameters related to the health of adolescents. Gamification has been used to verify the increase in adherence to healthy habits or the development of health-related skills, but there are still few results for the adolescent population. We expect that the systematic review could indicate strategies with gamification interventions and also determine how these strategies can improve health parameters of adolescent students, and they will be available as a reference for these interventions.

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Maternal, newborn, child and adolescent health: challenges for the next decade

Cited by 14 publications

References 23 publications

M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch

M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch

Neonatal Peyer’s patch cDC activation as a pacemaker of postnatal immune maturation

Gamification as a health education strategy of adolescents at school: Protocol for a systematic review and meta-analysis

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