Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks

Muhammad, Tahir; Wan, Yanling; Lv, Yao; Li, H Y; Naushad, Wasifa; Chan, Wai‐Yee; Lü, Gang; Chen, Zi‐Jiang; Liu, Hong Bin

doi:10.1111/obr.13603

Cited by 7 publications

(2 citation statements)

References 138 publications

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“…The prevalence of obesity, both during pregnancy and generally in the population, is increasing 1 . 29% of women in America enter pregnancy with obesity, defined as a body mass index (BMI) >= 30 kg/m 2 2 , and the prevalence of maternal obesity (MO) is expected to go up to 47% by 2030 3 . Similar trends are present in countries around the world 4 .…”

Section: Introductionmentioning

confidence: 99%

Maternal obesity and offspring neurodevelopment are associated with hypoxic gene expression in term human placenta

Gunter-Rahman,

Mallett,

White

et al. 2024

Preprint

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One third of women in the United States are affected by obesity during pregnancy. Maternal obesity (MO) is associated with an increased risk of neurodevelopmental and metabolic disorders in the offspring. The placenta, located at the maternal-fetal interface, is a key organ determining fetal development and likely contributes to programming of long-term offspring health. We profiled the term placental transcriptome in humans (pre-pregnancy BMI 35+ [MO condition] or 18.5-25 [lean condition]) using single-nucleus RNA-seq to compare expression profiles in MO versus lean conditions, and to reveal potential mechanisms underlying offspring disease risk. We recovered 62,864 nuclei of high quality from 10 samples each from the maternal-facing and fetal-facing sides of the placenta. On both sides in several cell types, MO was associated with upregulation of hypoxia response genes. On the maternal-facing side only, hypoxia gene expression was associated with offspring neurodevelopmental measures, in Gen3G, an independent pregnancy cohort with bulk placental tissue RNA-seq. We leveraged Gen3G to determine genes that correlated with impaired neurodevelopment and found these genes to be most highly expressed in extravillous trophoblasts (EVTs). EVTs further showed the strongest correlation between neurodevelopment impairment gene scores (NDIGSs) and the hypoxia gene score. We reanalyzed gene expression of cultured EVTs, and found increased NDIGSs associated with exposure to hypoxia. Among EVTs, accounting for the hypoxia gene score attenuated 44% of the association between BMI and NDIGSs. These data suggest that hypoxia in EVTs may be a key process in the neurodevelopmental programming of fetal exposure to MO.

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Section: Introductionmentioning

confidence: 99%

Maternal obesity and offspring neurodevelopment are associated with hypoxic gene expression in term human placenta

Gunter-Rahman,

Mallett,

White

et al. 2024

Preprint

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“…Maternal obesity causes an elevated body mass index (BMI), another risk factor that adversely affects FI. The predicted incidence of maternal obesity is expected to increase from 45-50% till 2030 according to the World Obesity Federation [14]. The fertility rate decreases in accordance with increasing obesity; women with a BMI > 30 kg/m 2 have a 2.7-fold amplified risk of infertility, as well as around a 25-37% chances of miscarriage.…”

Section: Introductionmentioning

confidence: 99%

Molecular Screening of the Thrombophilic Variants Performed at G-141 Laboratory among Saudi Infertile Women

Alageel,

Alhaizan,

Neyazi

et al. 2023

Applied Sciences

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Infertility is a major issue at present and is a common disease that exists in both male and female reproductive systems, described as failure to attain pregnancy. The most important physiological phenomenon for establishing clinical pharmacy is defined as female infertility (FI). Obesity enhances the risks for many chronic disorders, especially causing a high risk for women’s reproductive health. The relationship between infertile women and thrombophilia is characterized by abnormal blood coagulation. Among the thrombophilic variants, Factor V Leiden (FVL), prothrombin (PT) and methyl tetrahydrofolate reductase (MTHFR) in genes such as G1691A (rs6020), G20210A (rs1799963) and C677T (rs1801133) are commonly studied in the majority of human diseases. In this case–control study, we investigated the role of thrombophilic variants such as G1691A, G20210A and C677T in the FVL, PII and MTHFR genes in Saudi infertile women. Based on sample size calculation, 100 female infertile and 100 control (fertile) women were selected based on inclusion and exclusion criteria. Genotyping was performed with polymerase chain reaction and followed with precise restriction enzymes, which can accurately detect the nucleotide amendment variants in G1691A, G20210A and C677T. The required statistics were applied between the case (infertile) and control (fertile) women to document the role of the G1691A, G20210A and C677T variants in Saudi infertile women. In this study, age, weight and BMI were found to be high in the control women in comparison to the infertile women. None of the genotypes, genetic models or allele frequencies were associated with G1691A, G20210A or C677T SNPs (p > 0.05). Furthermore, the regression model and ANOVA analysis also showed negative statistical associations. The combination of genotypes and allele frequencies among G1691A, G20210A and C677T SNPs showed positive associations in the recessive model (p = 0.0006). Finally, the GMDR model showed moderate associations with the gene–gene interaction, dendrogram and depletion models. Finally, this study confirmed that thrombophilic SNPs have no role and may not be involved in Saudi infertile women.

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Impact of diet-induced maternal obesity on the reproductive capacity of F1 female offspring and the early development of the second generation

Meneghini,

Flores Quiroga,

Heinecke

et al. 2024

The Journal of Nutritional Biochemistry

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Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks

Cited by 7 publications

References 138 publications

Maternal obesity and offspring neurodevelopment are associated with hypoxic gene expression in term human placenta

Maternal obesity and offspring neurodevelopment are associated with hypoxic gene expression in term human placenta

Molecular Screening of the Thrombophilic Variants Performed at G-141 Laboratory among Saudi Infertile Women

Impact of diet-induced maternal obesity on the reproductive capacity of F1 female offspring and the early development of the second generation

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