Maternal Obesity, Gestational Diabetes, and Early-Onset Puberty

Hunt, Summer; Hellwig, Jennifer P.

doi:10.1016/s1751-4851(16)30194-5

Cited by 2 publications

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“…Of the remaining 248, 230 were not relevant to the research question and were excluded on the basis of title and abstract, leaving 18 studies for full-text assessment. Eleven articles were excluded at this stage: four articles were conference proceedings, oral presentations or commentary articles ( 14 , 15 , 16 , 17 ); two articles did not include any of the outcomes we were interested in ( 18 , 19 ); one article did not analyse GDM as a predictor for pubertal timing due to an insufficient number of subjects with GDM ( 20 ); two articles did not provide a comparator cohort ( 21 , 22 ); two articles only reported Tanner stage at baseline and did not consider age/timing of puberty ( 23 , 24 ). The seven remaining studies were included in the review ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Subramanian

Idkowiak

Toulis

et al. 2021

European Journal of Endocrinology

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Context: The incidence of gestational diabetes mellitus (GDM) has been on the rise, driven by maternal obesity. In parallel, pubertal tempo has increased in the general population, driven by childhood obesity. Objective: To evaluate the available evidence on pubertal timing of boys and girls born to mothers with GDM. Data Sources: We searched MEDLINE, EMBASE, CINAHL Plus, Cochrane library and grey literature for observational studies up to October 2019. Study selection and extraction: Two reviewers independently selected studies, collected data and appraised the studies for risk of bias. Results were tabulated and narratively described. Results: Seven studies (six for girls and four for boys) were included. Study quality score was mostly moderate (ranging from 4 to 10 out of 11). In girls born to mothers with GDM, estimates suggest earlier timing of pubarche, thelarche and menarche although for each of these outcomes only one study each showed a statistically significant association. In boys, there was some association between maternal GDM and earlier pubarche, but inconsistency in the direction of shift of age at onset of genital and testicular development and first ejaculation. Only a single study analysed growth patterns in children of mothers with GDM, describing a 3-month advancement in the age of attainment of peak height velocity and a slight increase in pubertal tempo. Conclusions: Pubertal timing may be influenced by the presence of maternal GDM, though current evidence is sparse and of limited quality. Prospective cohort studies should be conducted, ideally coupled with objective biochemical tests.

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Section: Resultsmentioning

confidence: 99%

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Subramanian

Idkowiak

Toulis

et al. 2021

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Of the remaining 248, were not relevant to the research question and were excluded on the basis of title and abstract, leaving 18 studies for full-text assessment. Eleven articles were excluded at this stage: four articles were conference proceedings, oral presentations or commentary articles (13)(14)(15)(16); two articles did not include any of the outcomes we were interested in (17,18); one article did not analyse GDM as a predictor for pubertal timing due to an insufficient number of subjects with GDM (19); two articles did not provide a comparator cohort (20,21); two articles only reported Tanner stage at baseline and did not consider age/timing of puberty (22,23). The seven remaining studies were included in the review (Fig.…”

Section: Literature Search Resultsmentioning

confidence: 99%

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Subramanian

Idkowiak

Toulis

et al. 2020

Preprint

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Context: The incidence of gestational diabetes mellitus (GDM) has been on the rise, driven by maternal obesity. In parallel, pubertal tempo has increased in the general population, driven by childhood obesity. Ojective: To evaluate the available evidence on pubertal timing of boys and girls born to mothers with GDM. Data Sources: We searched MEDLINE, EMBASE, CINAHL Plus, Cochrane library and grey literature for observational studies up to October 2019. Study selection and extraction: Two reviewers independently selected studies, collected data and appraised study quality. Results were tabulated and narratively described as reported in the primary studies. Results: Seven articles (six for girls and four for boys) were included. Study quality score was mostly moderate (ranging from 4 to 10 out of 11). In girls born to mothers with GDM, estimates suggest earlier timing of pubarche, thelarche and menarche although for each of these outcomes only one study each showed a statistically significant association. In boys, there was some association between maternal GDM and earlier pubarche, but inconsistency in the direction of shift of age at onset of genital and testicular development and first ejaculation. Only a single study analysed growth patterns in children of mothers with GDM, describing a 3-month advancement in the age of attainment of peak height velocity and a slight increase in pubertal tempo. Conclusions: Pubertal timing may be influenced by the presence of maternal GDM, though current evidence is sparse and of limited quality. Prospective cohort studies should be conducted, ideally coupled with objective biochemical tests.

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Maternal Obesity, Gestational Diabetes, and Early-Onset Puberty

Cited by 2 publications

References 0 publications

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

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