Maternal Obesity Is Associated With the Formation of Small Dense LDL and Hypoadiponectinemia in the Third Trimester

Meyer, Barbara J.; Stewart, Frances; Brown, Elizabeth A.; Cooney, Josephine; Nilsson, Solveig; Olivecrona, Gunilla; Ramsay, Judith; Griffin, Bruce A.; Caslake, Muriel; Freeman, Dilys J.

doi:10.1210/jc.2012-3481

Cited by 52 publications

(61 citation statements)

References 52 publications

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“…In contrast, obese women demonstrate reduced insulin sensitivity from an earlier gestation, particularly with regard to lipid metabolism [1]. Using non-NMR methods, others have reported dyslipidaemia in obese vs normal-weight pregnancy, including raised total and LDL-cholesterol, lower HDLcholesterol and raised triacylglycerols from the first trimester [24][25][26][27]. The exaggerated dyslipidaemia in obese women prior to and at the time of diagnosis of GDM in the present study suggests exaggeration of these metabolic processes, reflecting enhanced insulin resistance in adipose tissue and reduced suppression of lipolysis [28].…”

Section: Discussionmentioning

confidence: 99%

Metabolic profiling of gestational diabetes in obese women during pregnancy

et al. 2017

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Aims/hypothesis Antenatal obesity and associated gestational diabetes (GDM) are increasing worldwide. While pre-existing insulin resistance is implicated in GDM in obese women, the responsible metabolic pathways remain poorly described. Our aim was to compare metabolic profiles in blood of obese pregnant women with and without GDM 10 weeks prior to and at the time of diagnosis by OGTT. Methods We investigated 646 women, of whom 198 developed GDM, in this prospective cohort study, a secondary analysis of UK Pregnancies Better Eating and Activity Trial (UPBEAT), a multicentre randomised controlled trial of a complex lifestyle intervention in obese pregnant women. Multivariate regression analyses adjusted for multiple testing, and accounting for appropriate confounders including study intervention, were performed to compare obese women with GDM with obese non-GDM women. We measured 163 analytes in serum, plasma or whole blood, including 147 from a targeted NMR metabolome, at time point 1 (mean gestational age 17 weeks 0 days) and time point 2 (mean gestational age 27 weeks 5 days, at time of OGTT) and compared them between groups. Results Multiple significant differences were observed in women who developed GDM compared with women without GDM (false discovery rate corrected p values <0.05). Most were evident prior to diagnosis. Women with GDM demonstrated raised lipids and lipoprotein constituents in VLDL subclasses, greater triacylglycerol enrichment across lipoprotein particles, higher branched-chain and aromatic amino acids and different fatty acid, ketone body, adipokine, liver and inflammatory marker profiles compared with those without GDM. Conclusions/interpretation Among obese pregnant women, differences in metabolic profile, including exaggerated dyslipidaemia, are evident at least 10 weeks prior to a diagnosis of GDM in the late second trimester.

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Section: Discussionmentioning

confidence: 99%

Metabolic profiling of gestational diabetes in obese women during pregnancy

et al. 2017

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“…More work is needed to understand the mechanisms, but it is thought that the spectrum of cardiometabolic changes observed in obese pregnancy [27][28][29] potentially unmask a vascular phenotype that may reemerge in later life with adverse cardiovascular events. In a previous study, we demonstrated an association between maternal obesity and cardiovascular mortality in the adult offspring of overweight and obese mothers.…”

Section: Perspectivesmentioning

confidence: 99%

Maternal Obesity During Pregnancy Associates With Premature Mortality and Major Cardiovascular Events in Later Life

et al. 2015

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“…A recent study has investigated the pattern of changes in lipid profiles during pregnancy in obese and normal healthy-weight women. 40 In both groups, there were normal physiological increases in total cholesterol, triglycerides, very low density lipoprotein, and low density lipoprotein to mobilize lipids into the maternal circulation. However, the obese mothers had higher triglyceride levels than normal healthy-weight women at the start of pregnancy.…”

Section: Lipid Metabolismmentioning

confidence: 89%

Effects of maternal obesity on early and long-term outcomes for offspring

Stirrat¹,

Reynolds²

2014

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Abstract:The prevalence of maternal obesity has increased significantly in recent years, and obesity is currently the most common comorbidity of pregnancy. Pregnancies of obese women are often defined as "high-risk" for the purposes of clinical care, with many well documented risks to the mother and developing baby. Maternal physiology and metabolism is dysregulated in the context of obesity, which may contribute to some of the adverse outcomes during pregnancy. Furthermore, maternal obesity has been hypothesized to cause harmful effects for the developing baby through "early life programming." This review will examine evidence from human studies for outcomes of offspring from obese women during pregnancy, during labor, during the neonatal period, and later in life.

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Maternal Obesity Is Associated With the Formation of Small Dense LDL and Hypoadiponectinemia in the Third Trimester

Abstract: Maternal obesity is associated with an atherogenic LDL subfraction phenotype and may provide a mechanistic link to poor vascular function and adverse pregnancy outcome.

Cited by 52 publications

References 52 publications

Metabolic profiling of gestational diabetes in obese women during pregnancy

Metabolic profiling of gestational diabetes in obese women during pregnancy

Maternal Obesity During Pregnancy Associates With Premature Mortality and Major Cardiovascular Events in Later Life

Effects of maternal obesity on early and long-term outcomes for offspring

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