Maternal protein malnutrition in the rat: Effect on protein and two enzymes in the milk

Sturman, John A.; Devine, Evelyn A.; Resnick, Oscar; Morgane, Peter J.

doi:10.1016/s0271-5317(86)80185-3

“…The suppression of longitudinal growth of long bones of animals caused by protein malnutrition during lactation has been described by several studies, and most likely occurs as a result of a quantitative decrease in bone formed than due to a change in the mineral content. 27,28 Our findings support this hypothesis, since there was no difference in the mineral bone content among the groups, even when being influenced by the treadmill training during pregnancy and/or protein malnutrition of the mother during pregnancy and lactation.…”

Section: Discussionsupporting

confidence: 78%

Repercussões do exercício físico durante a gestação e da desnutrição proteica durante a gestação e lactação sobre o desenvolvimento e crescimento do fêmur da prole

Monteiro¹,

Paes²,

Santos³

et al. 2010

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objective: To evaluate the effects of physical training of mother rats during pregnancy associated with a low-protein diet offered during pregnancy and lactation on the development and growth of the femur of their offspring.Methods: Forty 90-day old male Wistar rats were divided into four groups: pups of sedentary nourished mothers, pups of sedentary malnourished mothers, pups of trained nourished mothers, and pups of trained malnourished mothers; all groups included 10 rats. Physical training on a treadmill for 8 weeks, 5 weeks before conception and 3 weeks in the gestational period for mother rats of pups of trained nourished mothers and pups of trained malnourished mothers. Induction of low-protein diet to the mother rats during pregnancy and lactation for the groups of pups of sedentary malnourished mothers and trained malnourished mothers. After the pups were sacrificed, on the 90th day of life, we analyzed weight, length, and femoral bone mineral content.Results: Decreased body weight, femur weight, and femur length (p < 0.05) were observed for the groups of pups of sedentary malnourished mothers and trained malnourished mothers in comparison with to the groups of pups of sedentary nourished mothers and trained nourished mothers, respectively. There was no difference in bone mineral content of the femur in either of the groups. Conclusion:Mild physical training on the treadmill during pregnancy does not interfere with bone development and growth of the offspring. However, protein malnutrition during this period and during lactation promotes permanent damage to the bone structure of the offspring.

show abstract

“…Previous studies [9][10][11]34] and the results of this study show that total milk protein concentration does not seem to be affected by suboptimal maternal nutrition. However, there are probably situations when some specific proteins increase and others decrease in concentration, although not significantly affecting total protein concentration in the milk [35,36]. The implications of such events could be considerable in situations when the concentration of proteins in milk that have specific physiological roles decreases, whereas other proteins not having bioactivity increase.…”

Section: Discussionmentioning

confidence: 99%

Effect of suboptimal nutrition during lactation on milk protein gene expression in the rat

Zubieta

¹

,

Lönnerdal

²

2006

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…A supressão do crescimento longitudinal de ossos longos de animais causada pela desnutrição proteica durante o período de amamentação foi descrita por diversos estudos, e ocorre provavelmente mais como resultado de uma diminuição quantitativa de osso formado do que devido a uma alteração no conteúdo mineral 27,28 . Nossos achados corroboram essa hipótese, uma vez que não foi encontrada diferença no conteúdo mineral ósseo entre os grupos, mesmo recebendo influências do treino em esteira durante a gestação e/ou a desnutrição proteica materna durante a gestação e lactação.…”

Section: Discussionunclassified

Effects of physical exercise during pregnancy and protein malnutrition during pregnancy and lactation on the development and growth of the offspring’s femur

Monteiro

¹

,

Paes

²

,

Santos

³

et al. 2010

View full text Add to dashboard Cite

Objective: To evaluate the effects of physical training of mother rats during pregnancy associated with a low-protein diet offered during pregnancy and lactation on the development and growth of the femur of their offspring.Methods: Forty 90-day old male Wistar rats were divided into four groups: pups of sedentary nourished mothers, pups of sedentary malnourished mothers, pups of trained nourished mothers, and pups of trained malnourished mothers; all groups included 10 rats. Physical training on a treadmill for 8 weeks, 5 weeks before conception and 3 weeks in the gestational period for mother rats of pups of trained nourished mothers and pups of trained malnourished mothers. Induction of low-protein diet to the mother rats during pregnancy and lactation for the groups of pups of sedentary malnourished mothers and trained malnourished mothers. After the pups were sacrificed, on the 90th day of life, we analyzed weight, length, and femoral bone mineral content.Results: Decreased body weight, femur weight, and femur length (p < 0.05) were observed for the groups of pups of sedentary malnourished mothers and trained malnourished mothers in comparison with to the groups of pups of sedentary nourished mothers and trained nourished mothers, respectively. There was no difference in bone mineral content of the femur in either of the groups. Conclusion:Mild physical training on the treadmill during pregnancy does not interfere with bone development and growth of the offspring. However, protein malnutrition during this period and during lactation promotes permanent damage to the bone structure of the offspring. J Pediatr (Rio J). 2010;86(3):233-238:Physical training, protein malnutrition, pregnancy, post-natal, femur. ResumoObjetivo: Avaliar os efeitos do treino físico imposto às ratas mães durante a gestação associado a uma dieta hipoproteica imposta durante os períodos gestacional e de lactação sobre o desenvolvimento e crescimento do fêmur da prole.Métodos: Quarenta ratos machos Wistar, 90 dias de vida, foram divididos em quatro grupos: filhotes de mãe sedentária nutrida, filhotes de mãe sedentária desnutrida, filhotes de mãe treinada nutrida e filhotes de mãe treinada desnutrida, todos com n = 10. Treinamento físico em esteira durante 8 semanas, 5 semanas antes da concepção e 3 no período gestacional para as ratas mães dos grupos filhotes de mães treinada nutrida e treinada desnutrida. Indução da dieta hipoproteica às ratas mães durante a gestação e lactação para os grupos filhotes de mães sedentária desnutrida e treinada desnutrida. Após sacrifício, no 90º dia de vida, analisou-se peso, comprimento e conteúdo mineral ósseo do fêmur dos filhotes.Resultados: Peso corporal, peso femoral e comprimento femoral diminuídos (p < 0,05) para os grupos filhotes de mães sedentária desnutrida e treinada desnutrida em relação aos grupos filhotes de mães sedentária nutrida e treinada nutrida, respectivamente. Não houve diferença no conteúdo mineral ósseo do fêmur em nenhum dos grupos. Conclusão:O treinamento físico leve em...

show abstract

Maternal protein malnutrition in the rat: Effect on protein and two enzymes in the milk

Cited by 20 publications

References 24 publications

Repercussões do exercício físico durante a gestação e da desnutrição proteica durante a gestação e lactação sobre o desenvolvimento e crescimento do fêmur da prole

Repercussões do exercício físico durante a gestação e da desnutrição proteica durante a gestação e lactação sobre o desenvolvimento e crescimento do fêmur da prole

Effect of suboptimal nutrition during lactation on milk protein gene expression in the rat

Effects of physical exercise during pregnancy and protein malnutrition during pregnancy and lactation on the development and growth of the offspring’s femur

Contact Info

Product

Resources

About