Maternal Psychopathology and Infant Development at 18 Months: The Impact of Maternal Personality Disorder and Depression

Conroy, Simon; Pariante, Carmine M.; Marks, Maureen; Davies, Helen; Farrelly, Simone; Schacht, Robin; Moran, Paul

doi:10.1016/j.jaac.2011.10.007

Cited by 119 publications

(95 citation statements)

References 36 publications

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“…Not only is maternal depression among the most prevalent psychiatric disorders, but it also is the most underdiagnosed in the community and has direct negative consequences both for the suffering individual and for her child (1). Longitudinal studies have demonstrated that children of depressed mothers show greater vulnerability to psychopathology, particularly to anxiety and depressive disorders (2), oppositional conduct, neurocognitive deficits (3), and maladaptive social behavior (4). However, while theoretical models suggest that the transmission of risk from depressed mothers to their children involves both genetic transmission and dysfunctional parenting, little research has examined both genes and parent-child relatedness in order to provide an integrated view of maternal depression (4).…”

Section: Discussionmentioning

confidence: 99%

Impact of Maternal Depression Across the First 6 Years of Life on the Child’s Mental Health, Social Engagement, and Empathy: The Moderating Role of Oxytocin

Apter-Levy¹,

Feldman²,

Vakart³

et al. 2013

AJP

225

185

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Objective: Maternal depression across the postbirth period has long-term negative consequences for infant development. Little is known of the neurobiological underpinnings, but they could involve oxytocin, a neuropeptide that is dysfunctional in depression and is implicated in birth and parenting.Method: The authors recruited a community cohort of women with high or low depression scores 2 days after childbirth and measured depression again at 6 and 9 months. When the child was 6, the authors evaluated the families of 46 chronically depressed mothers and 103 mothers reporting no depression since childbirth. The child was assessed for psychiatric diagnoses, social engagement, and empathy. Mother, father, and child were tested for salivary oxytocin level and variation in the rs2254298 single nucleotide polymorphism on the OXTR gene.

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Section: Discussionmentioning

confidence: 99%

Impact of Maternal Depression Across the First 6 Years of Life on the Child’s Mental Health, Social Engagement, and Empathy: The Moderating Role of Oxytocin

Apter-Levy¹,

Feldman²,

Vakart³

et al. 2013

AJP

225

185

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“…The impact on mothers can be considerable during the perinatal period because of new emotional, social, financial and physical challenges. Additionally, the pre-and postnatal periods have significant impacts on future physical, mental and cognitive development of offspring: children of mothers with perinatal mental illness are exposed to higher risks of low birth-weight, reduced child growth, intellectual, behavioural and socio-emotional problems (Hay et al, 2010;Surkan et al, 2011;Conroy et al, 2012;Kingston and Tough, 2014;Pearson et al, 2013a,b;O'Donnell et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Lifetime costs of perinatal anxiety and depression

Bauer

Knapp

Parsonage

2016

Journal of Affective Disorders

283

202

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BackgroundAnxiety and depression are common among women during pregnancy and the year after birth. The consequences, both for the women themselves and for their children, can be considerable and last for many years. This study focuses on the economic consequences, aiming to estimate the total costs and health-related quality of life losses over the lifetime of mothers and their children. MethodA pathway or decision modelling approach was employed, based on data from previous studies. Systematic and pragmatic literature reviews were conducted to identify evidence of impacts of perinatal anxiety and depression on mothers and their children. ResultsThe present value of total lifetime costs of perinatal depression (anxiety) was £75,728 (£34,811) per woman with condition. If prevalence estimates were applied the respective cost of perinatal anxiety and depression combined was about £8,500 per woman giving birth; for the United Kingdom, the aggregated costs were £6.6 billion. The majority of the costs related to adverse impacts on children and almost a fifth were borne by the public sector. LimitationsThe method was exploratory in nature, based on a diverse range of literature and encountered important data gaps. ConclusionsFindings suggest the need to allocate more resources to support women with perinatal mental illness. More research is required to understand the type of interventions that can reduce long-term negative effects for both mothers and offspring. Highlights Using modelling techniques, we estimated the lifetime costs of perinatal depression and anxiety reflecting the impact on mothers and children 1 ALSPAC = Avon Longitudinal Study of Parents and Children, ED = Education, HRQoL = Health-related quality of life, HSC = Health and social care, OOP = Out-of-pocket expenditure, NHS = National Health Service, p = probability, PL = Productivity loss, pp. = percentage points, PTB = Pre-term birth, RD = Risk difference, UC = Unpaid care, UK = United Kingdom, wks. = weeks, yrs. = years 2  We found that costs were substantial and that the majority related to the impact on children  There is a need to understand the role of interventions in alleviating symptoms and reducing long-term negative effects for both mothers and offspring.  New costing methods are required for conditions with transgenerational origins and impact.

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“…We therefore concentrated on the SAPAS [16], which exhibited encouraging results regarding the time required for completion (i.e., less than 5 minutes), and regarding its screening capacities where DSM-IV PDs were correctly identified in 90% of participants with a sensitivity of 94% and a specificity of 85%. Since the publication of the SAPAS in 2003, several researchers have used it in its initial form as an interview [37][38][39][40][41][42][43][44][45][46][47]. Various validations using new samples are also available [48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Adaptation and Validation of the Standardized Assessment of Personality – Abbreviated Scale as a Self-Administered Screening Test (SA-SAPAS)

Merlhiot¹

2014

J Psychol Psychother

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Personality disorder assessments are time-intensive and require trained interviewers. They are unlikely to be performed on a routine basis. In clinical and general populations, there is a requirement for short and robust self-administered screening tests for personality disorders. We first translated the original form of the SAPAS into French and validated it in a clinical sample (n=28). This adaptation revealed properties similar to those of the original version. The first and second studies validated the adaptation of the SA-SAPAS as a self-administered questionnaire in clinical (n=45) and general (n=186) populations. We were able to use the same cut-off (score ≥ 2) in both the clinical and general populations and this permitted correct identification in 89% of the clinical subjects (sensitivity of 97.3%; specificity of 50%) and 86% in the general population (sensitivity of 87.5%; specificity of 85.7%). These results suggest possible applications for researchers and clinicians, either as a routine screening test or as a selection tool in both general and clinical populations.

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Maternal Psychopathology and Infant Development at 18 Months: The Impact of Maternal Personality Disorder and Depression

Cited by 119 publications

References 36 publications

Impact of Maternal Depression Across the First 6 Years of Life on the Child’s Mental Health, Social Engagement, and Empathy: The Moderating Role of Oxytocin

Impact of Maternal Depression Across the First 6 Years of Life on the Child’s Mental Health, Social Engagement, and Empathy: The Moderating Role of Oxytocin

Lifetime costs of perinatal anxiety and depression

Adaptation and Validation of the Standardized Assessment of Personality – Abbreviated Scale as a Self-Administered Screening Test (SA-SAPAS)

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