Maternal pyrimidine nucleoside supplementation regulates fatty acid, amino acid and glucose metabolism of neonatal piglets

Gao, Lumin; Liu, Gangyi; Wang, Hongling; Wassie, Teketay; Wu, Xin

doi:10.1016/j.aninu.2022.07.011

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…In addition, aspartic acid is a precursor of pyrimidine metabolism. Pyrimidine nucleosides play a crucial role in the biological processes of animals, such as promoting growth, improving immunity, and regulating the composition of amino acids and FAs [55]. In the pyrimidine metabolism pathway, cytidine-3'-monophosphate was upregulated in Mth-18 and Mth-30, suggesting that it could promote flavor formation.…”

Section: Discussionmentioning

confidence: 99%

The Characterization of Subcutaneous Adipose Tissue in Sunit Sheep at Different Growth Stages: A Comprehensive Analysis of the Morphology, Fatty Acid Profile, and Metabolite Profile

Han,

He,

Yun

et al. 2024

Foods

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Adipose tissue is a crucial economically significant trait that significantly influences the meat quality and growth performance of domestic animals. To reveal the changes in adipose tissue metabolism during the growth of naturally grazing sheep, we evaluated the thickness, adipocyte morphology, fatty acid profile, and metabolite profile of subcutaneous adipose tissue (SAT) from naturally grazing Sunit sheep at 6, 18, and 30 months of age (referred to as Mth-6, Mth-18, and Mth-30, respectively). The fat thickness and adipocyte number were significantly increased with the growth of the sheep (p < 0.05), and the increase of which from Mth-18 to Mth-30 was less than that from Mth-6 to Mth-18. Additionally, the alpha-linolenic acid metabolism was enhanced and fatty acid (FA) elongation increased with growth. The metabolomic analysis revealed 76 differentially expressed metabolites (DEMs) in the SAT in different growth stages. Interestingly, we observed elongation of FAs in lipids correlated with sheep growth. Furthermore, the expression of acylcarnitines was downregulated, and fatty acid amides, aspartic acid, acetic acid and phosphocholine were upregulated in Mth-18 and Mth-30 compared to Mth-6. Altogether, the study found that the difference in SAT in Mth-6 was great compared to Mth-18 and Mth-30. An increase in fat deposition via adipocyte proliferation with the growth of the sheep in naturally grazing. The DEMs of acylcarnitines, fatty acid amides, aspartic acid, acetic acid, and phosphocholine emerged as potential key regulators of adipose tissue metabolism. These findings illustrate the variation in and metabolic mechanism of sheep adipose tissue development under natural grazing, thus providing valuable insights into improving the edible quality of sheep meat and developing the mutton sheep industry.

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Section: Discussionmentioning

confidence: 99%

The Characterization of Subcutaneous Adipose Tissue in Sunit Sheep at Different Growth Stages: A Comprehensive Analysis of the Morphology, Fatty Acid Profile, and Metabolite Profile

Han,

He,

Yun

et al. 2024

Foods

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“…Nucleotides play a vital role in various biological processes, including promoting growth [26], enhancing immunity [27] and regulating fatty acid composition in animals…”

Section: Discussionmentioning

confidence: 99%

“…Nucleotides play a vital role in various biological processes, including promoting growth [26], enhancing immunity [27] and regulating fatty acid composition in animals [28]. Previous studies have demonstrated that nucleotide supplementation can influence amino acid and fatty acid metabolism in sow-piglet and fish models [29].…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Comparison of Liver Tissue across Different Largemouth Bass (Micropterus salmoides) Strains

Zhou,

Zhang,

Yao

et al. 2023

Fishes

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Over the past few years, China has become a hotspot for the domestication of the commercially valuable largemouth bass (Micropterus salmoides). Although the food preference of this fish has been studied, little is known about the genes regulating its growth. Population breeding was performed using two indigenous strains (QT1 and QT2), with the results showing that the organ/body ratio, abdominal fat rate and the body weight gain of QT1 and QT2 were higher than for the offspring YL1 and Y3 which are extensively cultured in China. Subsequent RNA sequencing (RNA-Seq) allowed for the identification of potential genes and pathways involved in growth performance. Overall, the transcriptome analysis generated 89,056 transcripts and 42,529 Unigenes. A PCA revealed significant differences between QT1 and the other three strains, while the other three strains did not show much difference. A KEGG enrichment analysis of differentially expressed genes showed that steroid biosynthesis was the most enriched pathway among the four strains. These pathways could be related to the growth of largemouth bass. In addition, a co-expression network analysis suggested a strong interaction between liver steroid biosynthesis and the genes for photosynthesis, secondary metabolism and stress response. Taken together, the above results can provide new insights into the liver metabolism of different strains of largemouth bass during culture and provide references for the subsequent domestication and breeding programs of largemouth bass.

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“…Oral administration of 5 g of a nucleotide supplement (5 ′ CMP, 5 ′ UMP, 5 ′ AMP, and 5 ′ GMP) improved growth performance, intestinal morphology, and oxidative status in pre-weaned calves [364]. Supplementation of sows with uridine and cytidine (Ur:Cy = 1:1) reduced birth mortality, increased piglet birth weight, and modulated gene and protein expression of enzymes involved in lipid metabolism in the liver of neonatal piglets [365]. Maternal supplementation with yeast-based nucleotides containing 5 ′ UMP increased litter weaning weight and decreased diarrhea rate, promoted ileal villus development, increased secretory IgA in the ileum and jejunal, and increased jejunal and ileal expression of interleukin IL-17, IL-8, IL-1β, IL-10, and TNF-α in piglets [366].…”

Section: Nucleotides and Nucleosidesmentioning

confidence: 99%

A Comprehensive Review of Bovine Colostrum Components and Selected Aspects Regarding Their Impact on Neonatal Calf Physiology

Silva,

Pereira

et al. 2024

Animals

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Colostrum contains macro- and micronutrients necessary to meet the nutritional and energy requirements of the neonatal calf, bioactive components that intervene in several physiological aspects, and cells and microorganisms that modulate the calf’s immune system and gut microbiome. Colostrum is sometimes mistaken as transition milk, which, although more nutritive than whole milk, has a distinct biochemical composition. Furthermore, most research about colostrum quality and colostrum management focuses on the transfer of maternal IgG to the newborn calf. The remaining components of colostrum and transition milk have not received the same attention, despite their importance to the newborn animal. In this narrative review, a large body of literature on the components of bovine colostrum was reviewed. The variability of these components was summarized, emphasizing specific components that warrant deeper exploration. In addition, the effects of each component present in colostrum and transition milk on several key physiological aspects of the newborn calf are discussed.

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Maternal pyrimidine nucleoside supplementation regulates fatty acid, amino acid and glucose metabolism of neonatal piglets

Cited by 6 publications

References 62 publications

The Characterization of Subcutaneous Adipose Tissue in Sunit Sheep at Different Growth Stages: A Comprehensive Analysis of the Morphology, Fatty Acid Profile, and Metabolite Profile

The Characterization of Subcutaneous Adipose Tissue in Sunit Sheep at Different Growth Stages: A Comprehensive Analysis of the Morphology, Fatty Acid Profile, and Metabolite Profile

Transcriptomic Comparison of Liver Tissue across Different Largemouth Bass (Micropterus salmoides) Strains

A Comprehensive Review of Bovine Colostrum Components and Selected Aspects Regarding Their Impact on Neonatal Calf Physiology

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