Maternal resveratrol supplementation ameliorates bisphenol A-induced atherosclerotic lesions formation in adult offspring ApoE−/− mice

Functional components of Chinese rice wine can ameliorate diabetic cardiomyopathy through the modulation of autophagy, apoptosis, gut microbiota, and metabolites

“…Polyphenols, polypeptides, and oligosaccharides are present in many foods and beverages, holding antioxidant and anti-inflammatory effects as well as the ability to alter gut microbiota composition ( 10 – 13 ). For example, resveratrol, a red wine polyphenol, exerts cardiovascular protective effects against myocardial fibrosis and atherosclerosis ( 28 , 29 ). Chinese rice wine is fermented from glutinous rice; it is not only rich in polyphenols but also high in polypeptides and oligosaccharides ( 6 ).…”

Bisphenol A—What Do We Know? A Global or Local Approach at the Public Health Risk Level

“…Bisphenol A (BPA) has been shown to be associated with estrogenicity and endocrine-disrupting properties, has adverse neuropsychiatric effects and may be involved in the formation of NETs; it may be indirectly involved in miscarriage, cardiovascular disease, especially hypertension, reduced heart rate variability, diabetes, obesity, eye disease, allergic skin reactions, respiratory irritation, acute/chronic kidney disease, and liver disease ( Figure 1 ). However, the effects of BPA depend on the dose, the sex of the patient, the tissue and developmental stage of the exposed tissue/organ, and the time of exposure [ 14 , 18 , 19 , 21 , 24 , 26 , 28 , 29 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

“…According to the World Health Organization, there is no conclusive evidence that BPA affects immune function [ 13 , 42 ]; meanwhile, EFSA has confirmed its negative effects [ 7 , 14 ]. BPA is most commonly detected in blood (including umbilical cord, menstrual), urine, breast milk, hair, adipose tissue, amniotic fluid, or semen [ 12 , 13 , 28 , 39 ]. BPA concentrations in urine can be determined using a variety of methods, such as mass spectrometry (MS), HPLC, radioimmunoassay (RIA), immunoenzymatic immunosorbent assay (ELISA).…”

Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use

“…However, the molecular mechanisms involving BPA-induced autophagy modulation are yet to be fully understood. This may help in future treatments and drug discoveries [ 155 , 156 ].…”

“…RSV treatment has been shown to be effective against BPA-induced cellular toxicity in rat salivary glands [ 280 ]. In a recent study, RSV was a potential candidate for preventing perinatal BPA-induced atherosclerosis lesion formation in the adult offspring Apo E mice [ 155 ]. In rats, RSV treatment was effective in preventing liver histopathological changes caused by BPA exposure [ 281 ].…”