Maternal Rh D status, anti-D immune globulin exposure during pregnancy, and risk of autism spectrum disorders

Croen, Lisa; Matevia, Marilyn; Yoshida, Cathleen K.; Grether, Judith K.

doi:10.1016/j.ajog.2008.04.044

Cited by 40 publications

(24 citation statements)

References 27 publications

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“…Numerous studies by the same researchers (Geier and Geier 2003a, b, 2004, 2007bYoung et al 2008;Geier et al 2013) showed a relationship between exposure to TM and neurodevelopmental disorders, including autism. In contrast, other reports did not find any association between thimerosal-containing vaccines and ASD (Croen et al 2008 Price et al 2010;Schultz 2010) or neuropsychological impairments (Parker et al 2004;Marques et al 2010;Chen et al 2013). To date, there are no reliable data confirming thimerosal as an etiological agent in autism development; however, it cannot be excluded that individual gene profile and gene-environment interaction may play a dramatic role in modulating the individual response to TM risk exposure (Aschner and Ceccatelli 2010).…”

Section: Thimerosal: An Association With Autism?contrasting

confidence: 41%

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Gorini

Muratori

Morales

2014

Rev J Autism Dev Disord

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An increasing evidence supports the role of industrial chemicals as contributors to the development of neurobehavioral disorders, including autism spectrum disorders, whose prevalence has progressively increased in recent years. Heavy metals, in particular, are recognized as neurodevelopmental toxins since they can be responsible of fetal damages which lead to neurological defects, developmental delays, learning disabilities and behavioral abnormalities. Most of the reviewed studies reported a relationship between exposure to metals during perinatal and early childhood periods and increased risk for autism. Moreover, the effects resulting from co-exposure to multiple metals should not be underestimated, especially in the assessment of children who live in developing countries or near heavily contaminated sites.

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Section: Thimerosal: An Association With Autism?contrasting

confidence: 41%

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Gorini

Muratori

Morales

2014

Rev J Autism Dev Disord

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“…Among the 50 children evaluated with the ADI-R and ADOS-G, 94% met criteria for ASD on both instruments, and 100% met criteria on at least one (Croen et al 2008). In addition, record-review validation studies conducted by the investigators which included full review of diagnostic information recorded in KPNC medical records have demonstrated that at least 90% of children with an ASD diagnosis recorded in the KPNC electronic databases had documentation in their records consistent with a diagnosis of autism based on DSM-IV criteria (Croen et al 2008). The prevalence of ASD within this study population (4.76/1,000) is within the range reported among U.S. children for this time period (Autism and Developmental Disabilities Monitoring Network 2007).…”

Section: Discussionmentioning

confidence: 99%

Antenatal Ultrasound and Risk of Autism Spectrum Disorders

Grether

Yoshida

et al. 2009

J Autism Dev Disord

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We evaluated antenatal ultrasound (U/S) exposure as a risk factor for autism spectrum disorders (ASD), comparing affected singleton children and control children born 1995-1999 and enrolled in the Kaiser Permanente health care system. Among children with ASD (n = 362) and controls (n = 393), 13% had no antenatal exposure to U/S examinations; case-control differences in number of exposures during the entire gestation or by trimester were small and not statistically significant. In analyses adjusted for covariates, cases were generally similar to controls with regard to the number of U/S scans throughout gestation and during each trimester. This study indicates that antenatal U/S is unlikely to increase the risk of ASD, although studies examining ASD subgroups remain to be conducted.

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“…Although accumulating evidence shows no increased risks from exposure to vaccines containing thimerosal (360)(361)(362)(363)(364)(365)(366)(367)(368)(369)(370), the U.S. Public Health Service and other organizations have recommended that efforts be made to eliminate or reduce the thimerosal content in vaccines as part of a strategy to reduce mercury exposures from all sources (360,361). LAIV, RIV, and most single-dose vial or syringe preparations of IIV do not contain thimerosal.…”

Section: Thimerosalmentioning

confidence: 99%