Maternal serum adiponectin at 11 to 13 weeks of gestation in the prediction of macrosomia

Abstract

Maternal serum adiponectin at 11 to 13 weeks is a useful biomarker for early prediction of macrosomia.

Components of metabolic syndrome in the first trimester of pregnancy as predictors of adverse perinatal outcome

“…The likely mechanism underlying a lower adiponectin serum concentration and the presence of GDM is increased insulin resistance and glucose intolerance. Similar observations have been noted by Nanda et al, who researched pregnant women delivering macrosomic neonates [7]. In the GDM group, we also confirmed the possible role of SHBG as a marker of liver response to insulin, as well as of insulin resistance, manifested by increased GGTP levels.…”

“…Levels of serum adiponectin, an adipocytokine released from adipose tissue, are inversely correlated with insulin resistance, and its reduced concentration is apparent from the first trimester of pregnancy. It is possible, that serum adiponectin may be a biomarker of metabolic derangement observed in obesity and GDM [7]. Additionally, fat tissue is responsible for the chronic inflammatory response, which in pregnancy can lead to endothelial dysfunction, a potential cause of preeclampsia [8].…”

Can fetal macrosomia be predicted and prevented?

“…This area remains in its infancy, and the results to date show only a relatively small improvement in overall prediction of macrosomia. 48 Low pregnancy-associated plasma protein A and increased beta human chorionic gonadotropin levels have been shown to be predictive in pregnancies complicated by growth restriction. However, the reverse has not proven true when it comes to the prediction of macrosomia.…”

“…The use of biomarkers for predicting macrosomia, from as early as the first trimester, has been investigated but with only marginal increase in detection. 48 These markers were used in combination with maternal risk profile.…”

The diagnostic accuracy of the usage of the <i>Fetal Medicine Foundation</i>’s (FMF) on-line risk calculator with first-trimester ultrasound for screening for preeclampsia in high-risk pregnant Brazilian population

“…Advances in fetal medicine and ultrasound imaging techniques have allowed extensive research on the role of first-trimester screening for several maternal and fetal conditions [4,[9][10][11][12][13][14]. This new assessment of risk factors using fetal, maternal and biochemical markers suggests new approaches for prenatal care that are more focused on the first rather than third trimester [14,15].…”